Real-world healthcare resource utilization related to migraine treatment failure: a panel-based chart review in France, Germany, Italy, and Spain

Real-world migraine-related healthcare resource utilization and costs associated with improved vs. worsened/stable migraine: a panel-based chart review in France, Germany, Italy, and Spain

“…The economic burden of migraine in Europe has been well-documented [5][6][7][8]26,27]. Furthermore, studies have demonstrated that CM is far more disabling and costlier than EM [9,11].…”

“…This study was a follow-on to a retrospective, non-interventional, panel-based chart review that collected anonymized patient-level clinical and HRU data via chart extraction between April and June 2018. The objective of the original parent study was to analyze the burden of patients with migraine in the outpatient and emergency room (ER) settings [26,27]. Subsequently, the protocol was amended to add the objective of quantifying and better understanding the impact of migraine on migraine-related HRU and costs.…”

Utilization of Preventive Therapy in Korean Migraine Patients

“…Based on the previous studies and clinical trials, we considered patients with more than four migraine days per month as candidates for preventive treatment. 4,12,13) To estimate each patient's migraine days, the defined daily dose (DDD) was used. DDD is an average maintenance dose of a medication used by adults, which allows the drug used to be expressed in a standardized unit.…”

Understanding the migraine treatment landscape prior to the introduction of calcitonin gene‐related peptide inhibitors: Results from the Assessment of TolerabiliTy and Effectiveness in MigrAINe Patients using Preventive Treatment (ATTAIN) study

“…Treatment disruption and lack of adherence to preventive therapies may also lead to heighted need for healthcare resources, such as emergency room (ER) or hospital visits. 15 Healthcare resource utilization (HRU) and associated costs can be considerable for patients with migraine. [16][17][18][19] The…”

“…Hepp et al 14 found that only 25% of CM patients were still taking a newly prescribed oral preventive medication as prescribed after six months, and a discouraging 83% had discontinued these preventive medications by 1 year, suggesting major clinical futility. Treatment disruption and lack of adherence to preventive therapies may also lead to heighted need for healthcare resources, such as emergency room (ER) or hospital visits 15 . Healthcare resource utilization (HRU) and associated costs can be considerable for patients with migraine 16–19 .…”