Reappearance of buffalo-origin-like porcine circovirus type 2 strains in swine herds in southern China

Zhai, Shao‐Lun; Zhou, Xia; Lin, Tao; Zhang, H.; Wen, Xintian; Zhou, Xiu-Rong; Jia, Chun-Ling; Tu, Du; Zhu, Xueliang; Chen, Q.-L.; Wei, Wen-Kang; Lv, Dian-Hong

doi:10.1016/j.nmni.2017.02.009

Cited by 7 publications

(6 citation statements)

References 11 publications

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“…All types of farm animals (e.g., goats, cattle, camels, and chickens) and farm worker can be infected by circoviruses [2, 24, 25]. PCV2 is an important member of this family and is one of the major agents causing PCVAD, resulting in serious economic and production losses in the porcine industry [3–8].…”

Section: Discussionmentioning

confidence: 99%

An epidemiological investigation of porcine circovirus 3 infection in cattle in Shandong province, China

et al. 2019

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Background Porcine circovirus type 3 (PCV3) is a single-stranded, closed circular DNA virus, which causes porcine dermatitis and nephropathy syndrome (PDNS), multisystemic inflammation, and reproductive failure. The present study aimed to investigate the seroprevalence of PCV3 in cattle ( Bos taurus ) in Shandong province, China, and examine its genome diversity. Results PCR amplification and sequencing showed that 74 of 213 bovine samples (34.7%) were positive for PCV3. Among them, the capsid gene ( n = 12) and the complete genome ( n = 4) were sequenced. These sequences had high identities to the reference capsid gene (98.0–100%) and the complete genome (97.5–99.8%). The PCV3 strains were classified into two different genotypes (PCV3a and PCV3b), according to phylogenetic analysis based on the complete genome and capsid gene sequences. Specifically, the bovine-origin strains in this study were grouped into PCV3a, showing a close relationship with PCV3-US/SD2016 (American strain; GenBank: KX966193.1). Notably, a comparison of the inferred amino acid sequences revealed a mutation from D124 to Y124. Conclusion This was the first seroprevalence and genetic investigation of PCV3 in cattle in Shandong province, China. The results could provide insights into the epidemiology and pathogenesis of this important virus.

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Section: Discussionmentioning

confidence: 99%

An epidemiological investigation of porcine circovirus 3 infection in cattle in Shandong province, China

et al. 2019

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“…It is worth noting that PCV2 could transmit to nonporcine hosts through cross-species transmission routes. Specifically, cattle, dogs and sheep can be infected with PCV2 (Li et al, 2011;Song et al, 2019;Wang et al, 2018;Zhai et al, 2017). Recently, a novel and genetically divergent circovirus, PCV3, was found in swine with PDNS, PMWS in the United States (Palinski et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

An epidemiological investigation of porcine circovirus 3 infection in dogs in the Guangxi Province from 2015 to 2017, China

et al. 2019

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A B S T R A C TPorcine circovirus type 3 (PCV3) is an emerging circovirus species associated with several diseases. The study aimed to investigate the frequency of porcine circovirus 3 (PCV3) and its coinfection with canine parvovirus type 2 (CPV-2) in dogs in the Guangxi province from 2015 to 2017, China, and to examine the genome diversity of PCV3. Using polymerase chain reaction (PCR) amplification and sequencing, 96 of 406 (23.6%)samples were positive for PCV3, 38 out of 406 (9.4%) samples were coinfected with both PCV3 and CPV-2. The CPV-positive rate was significantly higher in the PCV3-positive samples than in the non-PCV3 samples, and the difference was extremely significant (P < 0.01). The complete genome (n=4) and ten capsid genes (n=10) of PCV3 were sequenced. Multiple sequence alignment results showed that these sequences shared 98.5-100% nucleotide similarity with the reference genome sequence and 97.5-100% nucleotide similarity with the reference capsid gene sequence. PCV3 was classified into two different genotypes, according to phylogenetic analysis based on the whole genome. These strains were clustered in PCV3a, showing a close relationship with PCV3-US/SD2016. Surprisingly, we separately analyzed these PCV3 strains from the Guangxi province and found that the dog and pig PCV3 are from different branches. In summary, this was the first seroprevalence and genetic investigation of PCV3 in dogs in the Guangxi province, China, and the first complete genome PCV3 from dogs obtained in the world. The results provide insights into the epidemiology and pathogenesis of this important virus.

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“…USA beef contained circoviruses which showed 99% similarity to PCV2b (Li et al 2011). In China, cross-species transmission between the pig and buffalo was also reported recently (Zhai et al 2017). In China, 6.15% prevalence of PCV2 in goats was reported with PCV2d genotypes (Wang et al 2018).…”

Section: Transmissionmentioning

confidence: 76%

Porcine Circovirus

Saikumar

Das

2019

Recent Advances in Animal Virology

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Porcine circovirus (PCV) infections associated with post-weaning multisystemic wasting syndrome (PMWS) are characterized by weight loss, respiratory distress, jaundice, etc. Although PCV2 infection is ubiquitous, the prevalence of clinical disease is lower and the most common form is PCV2 subclinical infection. Recently, a novel porcine circovirus (PCV3) has been identified in pigs in the USA that is associated with porcine dermatitis nephropathy syndrome, acute myocarditis and multisystemic inflammation, etc. Genetic heterogeneity of PCV2 has been studied in Indian pig population. Different genotypes like PCV2a-2D, PCV2b-1C, PCV2d and recombinant strain between PCV2a-2C and PCV2b-1C are reported from different studies. PCV2 has been discovered in human faeces, human vaccines and beef. But its pathogenicity in humans is not clear. PCV detection is based on common golden standard techniques including nucleic acid and antigen detection in the tissues, in situ hybridization (ISH) and immunohistochemistry (IHC) using monoclonal or polyclonal antibody against PCV2, respectively. The commercial vaccines available are effective in reducing the severity of clinical diseases and improving production parameters. Recently, antiviral compounds have also shown promising results against PCV2. This chapter summarizes aetiology, epidemiology, transmission, immunopathobiology, diagnosis, prevention and control of porcine circovirus.

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Reappearance of buffalo-origin-like porcine circovirus type 2 strains in swine herds in southern China

Cited by 7 publications

References 11 publications

An epidemiological investigation of porcine circovirus 3 infection in cattle in Shandong province, China

An epidemiological investigation of porcine circovirus 3 infection in cattle in Shandong province, China

An epidemiological investigation of porcine circovirus 3 infection in dogs in the Guangxi Province from 2015 to 2017, China

Porcine Circovirus

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