Reappraisal of Histologic Features of the Acute Cutaneous Graft-Versus-Host Reaction Based on an Allogenic Rodent Model

Horn, Thomas; Bauer, Diane J.; Vogelsang, Georgia B.; Hess, A. D.

doi:10.1111/1523-1747.ep12392774

Cited by 27 publications

(12 citation statements)

References 11 publications

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“…In cases of minor alteration, the focus should be on the interpretation of vacuolar changes and apoptotic keratinocytes, including in the adnexal epithelia, although in the case of lichenoid disease, some element of inflammation should be present to allow the diagnosis to be established with confidence [88]. The archetypical features of both acute and chronic GVHD are superficial interface dermatitis with vacuolar change predominantly in the basilar layer or a lichenoid pattern of lymphocytic inflammation with or without lymphocyte satellitosis [4, 5, 89]. As a note of caution, since no single histological feature is pathognomonic of GVHD, the pattern of inflammation should be factored into the final interpretation [90].…”

Section: Histological Criteria For the Diagnosis Of Gvhdmentioning

confidence: 99%

NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report

Shulman

Cardona

Greenson

et al. 2015

Biology of Blood and Marrow Transplantation

250

242

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The 2005 National Institute of Health (NIH) Consensus Conference outlined histopathological diagnostic criteria for the major organ systems affected by both acute and chronic graft-versus-host disease (GVHD). The 2014 Consensus Conference led to this updated document with new information from histopathological studies of GVHD in the gut, liver, skin and oral mucosa and expanded discussion of GVHD in the lungs and kidneys. The recommendations for final histological diagnostic categories have been simplified from 4 categories to 3: no GVHD, possible, and likely GVHD based on better reproducibility achieved by combining the previous categories of consistent with and definite GVHD into the single category of likely GVHD. Issues remain in the histopathological characterization of GVHD, particularly with respect to the threshold of histological changes required for diagnostic certainty. Guidance is provided for the incorporation of biopsy information into prospective clinical studies of GVHD, particularly with respect to biomarker validation.

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Section: Histological Criteria For the Diagnosis Of Gvhdmentioning

confidence: 99%

NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report

Shulman

Cardona

Greenson

et al. 2015

Biology of Blood and Marrow Transplantation

250

242

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“…4 Also, some clinical pictures suggestive of GvHD could correspond to viral infections, particularly human herpesvirus 6. However, Horn et al 24 demonstrated in rodents that the presence of a dermal lymphocytic infiltrate was useful in distinguishing GvHD from preparative regimen toxicity. In conclusion, absolute criteria for acute GvHD diagnosis are still poor and the possibility of conditioning regimen toxicity or even viral infection must be always taken into account when examining BMT recipients with a skin eruption.…”

Section: Differential Diagnosismentioning

confidence: 99%

Cutaneous Graft-versus-Host Disease

Aractingi

Chosidow²

1998

Arch Dermatol

185

177

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“…(C) HISTOPATHOLOGY Biopsies of skin lesions of acute GVHD show vacuolization of the basal cells, spongiosis and dyskeratosis, satellite cell necrosis, subepidermal cleft formation, and complete loss of the epidermis, often with an accompanying dermal lymphocytic infiltrate (Lerner et al, 1974;Darmstadt et al, 1992;Horn et al, 1994).…”

Section: (B) Orial Presentationmentioning

confidence: 99%

Graft-vs.-Host Disease

Woo

Lee

Schubert

1997

Critical Reviews in Oral Biology & Medicine

134

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Bone marrow transplantation (BMT) is the treatment of choice for many leukemias, lymphomas, bone marrow failure syndromes, and immundeficiency disorders, and is the primary and salvage therapy for many solid malignancies. With the establishment of national and international marrow banks, unrelated allogeneic BMT is being performed with increasing frequency. Graft-vs.-host disease (GVHD) remains a major complication of allogeneic BMT, occurring in 25% to 70% of patients despite GVHD prophylaxis, with the skin, gastro-intestinal tract, and liver as primary target organs. Oral findings are seen in both acute and chronic GVHD. In acute GVHD, the oral lesions are often painful, erythematous, ulcerative, and desquamative. In chronic GVHD, they are lichenoid with associated erythema and ulcerations; additionally, they may be associated with a sicca syndrome characterized by xerostomia and progressive salivary gland atrophy. General principles of BMT are discussed, as are systemic and local therapeutic options for oral GVHD.

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Reappraisal of Histologic Features of the Acute Cutaneous Graft-Versus-Host Reaction Based on an Allogenic Rodent Model

Cited by 27 publications

References 11 publications

NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report

NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report

Cutaneous Graft-versus-Host Disease

Graft-vs.-Host Disease

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