Reappraisal of IVF stimulation in good prognosis patients – a prospective randomized study to compare mild versus standard long protocol

Mild stimulation for in vitro fertilization

“…Similarly, another meta-analysis mentioned earlier reported a comparable number of created embryos whether a low dose (150 IU/d) or high dose (>200 IU/d) of Gn was used (16). Notably, several RCTs identified the number of high-grade embryos from MS-IVF to be equivalent to, if not better than, those from C-IVF, regardless of total number of embryos created (5,8,9). Whether MS-IVF leads to acquisition of fewer embryos or not, good and comparable cumulative pregnancy rates from combining fresh and frozen-thawed ETs have been reported (7,39).…”

“…A more recent, large RCT (n ¼ 265) found incremental doses of FSH to have a direct correlation with the number of oocytes recovered, with no increment in the number of good-quality blastocysts; indeed, the blastocyst/oocyte ratio and fertilization rate demonstrated an inverse relationship with the dose of stimulation (6). Several other RCTs on a population of normal/high responders also found a trend toward a higher proportion of good-quality embryos/blastocysts with MS-IVF (7)(8)(9).…”

Clomiphene citrate and letrozole to reduce follicle‐stimulating hormone consumption during ovarian stimulation: systematic review and meta‐analysis

“…Twenty‐two studies (from 30 records) were included in the present review. The study flow diagram is shown in Figure S1.…”

“…Seven studies (from 11 records) evaluated CC in women with expected POR: one study used CC alone, two studies used CC and a lower FSH dose and four studies used CC, a lower FSH dose and a GnRH antagonist. Nine studies (from 11 records) evaluated CC in other women: seven studies used CC and a lower FSH dose and two studies used CC, a lower FSH dose and a GnRH antagonist. Four studies (from six records) evaluated LTZ in women with expected POR: two studies used LTZ and a lower FSH dose and two studies used LTZ, a lower FSH dose and a GnRH antagonist.…”

Clomifeno e letrozol para estimulação ovariana controlada em técnicas de reprodução assistida: revisão sistematizada e meta-análise

“…Nove estudos (de 11 registros) avaliaram CC em mulheres em que não se espera má resposta: sete usando CC + baixa dose de FSH (Fenichel 1988 (98) , Grochowski 1999 (117) , Harrison 1994 (102) , Karimzadeh 2011 (104,123) , Shelton 1991 (112) , Tummon 1992 (113) , Zhang 2016 (115,124) ) e dois estudos com CC + baixa dose de FSH + antagonista GnRH (Dastidar 2010 (100) , Lin 2006 (106) ).…”