Reappraisal of lymphatic mapping for midgut neuroendocrine patients undergoing cytoreductive surgery

Wang, Yi-Zarn; Carrasquillo, Jean P.; McCord, Elizabeth; Vidrine, Rhea; Lobo, Monica L.; Zamin, Syed A.; P, Boudreaux; Woltering, Eugene A.

doi:10.1016/j.surg.2014.05.028

Cited by 16 publications

(12 citation statements)

References 9 publications

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“…This approach led to selective resection of the involved lymph node basin, changing the extent of resection in 98% of the operations and preservation of the ileocecal valve in 44% of terminal ileum tumors, with no recurrences reported in 1 to 5 years of follow-up. 35 Lymphatic mapping is not a standardly performed procedure, 9 and recommendations from Uppsala and ENETS are that regional nodes should be removed along the segmental vessels up to their junction with the main trunk of the SMV (when feasible). 4,9,37 …”

Section: Resultsmentioning

confidence: 99%

The Surgical Management of Small Bowel Neuroendocrine Tumors

Howe¹,

Cardona²,

Fraker³

et al. 2017

Pancreas

Self Cite

295

188

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Small bowel neuroendocrine tumors (SBNETs) have been increasing in frequency over the past decades, and are now the most common type of small bowel tumor. Consequently, general surgeons and surgical oncologists are seeing more patients with SBNETs in their practices than ever before. The management of these patients is often complex, owing to their secretion of hormones, frequent presentation with advanced disease, and difficulties with making the diagnosis of SBNETs. Despite these issues, even patients with advanced disease can have long-term survival. There are a number of scenarios which commonly arise in SBNET patients where it is difficult to determine the optimal management from the published data. To address these challenges for clinicians, a consensus conference was held assembling experts in the field to review and discuss the available literature and patterns of practice pertaining to specific management issues. This paper summarizes the important elements from these studies and the recommendations of the group for these questions regarding the management of SBNET patients.

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Section: Resultsmentioning

confidence: 99%

The Surgical Management of Small Bowel Neuroendocrine Tumors

Howe¹,

Cardona²,

Fraker³

et al. 2017

Pancreas

Self Cite

295

188

View full text Add to dashboard Cite

show abstract

“…The importance of achieving R0 resection is therefore emphasized [94,95]. To limit the extent of small intestinal resection, lymphatic mapping has been suggested to be helpful, but it is not a standardized procedure and therefore not generally recommended [96,97]. …”

Section: Resection Of Localized and Regional Disease (Stage I-iii)mentioning

confidence: 99%

ENETS Consensus Guidelines Update for Neuroendocrine Neoplasms of the Jejunum and Ileum

et al. 2016

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“…A study of copy number alterations (CNA) in multifocal SI-NET primary tumors found that loss of chromosome 18 (chr18), the most frequent CNA, can affect different chromosome homologs in different samples within a patient (10), compatible with an independent clonal origin or late loss of chr18. Alternatively, multifocal SI-NETs have been proposed to represent "drop metastases" originating from regional lymph nodes, consistent with the limited spatial distribution of the intestinal tumors (11). Adding to the challenge is the low mutational burden, which reduces the number of exonic genetic markers.…”

Section: Introductionmentioning

confidence: 99%

Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine

Elias

Ardalan

Lindberg

et al. 2020

Preprint

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Small intestine neuroendocrine tumor (SI-NET), the most common cancer of the small bowel, often displays a curious multifocal phenotype with several intestinal tumors centered around a regional lymph node metastasis, yet the typical path of evolution of these lesions remains unclear. Here, we determined the complete genome sequences of 37 tumors from 5 patients with multifocal SI-NET, allowing elucidation of phylogenetic relationships between multiple intestinal tumors and metastases in individual patients. Notably, lack of shared somatic mutational events strongly supports that the intestinal tumors were of independent clonal origin. Furthermore, adjacent lymph node metastases arose from a single, typically centrally located, intestinal tumor. Thus, we propose that multifocal SI-NETs form primarily by independent somatic evolution rather than local metastatic spread.

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Reappraisal of lymphatic mapping for midgut neuroendocrine patients undergoing cytoreductive surgery

Cited by 16 publications

References 9 publications

The Surgical Management of Small Bowel Neuroendocrine Tumors

The Surgical Management of Small Bowel Neuroendocrine Tumors

ENETS Consensus Guidelines Update for Neuroendocrine Neoplasms of the Jejunum and Ileum

Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine

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