Reappraising hyalinizing clear cell carcinoma: A population‐based study with molecular confirmation

Hernández-Prera, Juan C.; Kwan, Ricky; Tripodi, Joseph; Chiosea, Simion I.; Cordon‐Cardo, Carlos; Najfeld, Vesna; Demicco, Elizabeth G.

doi:10.1002/hed.24637

Cited by 32 publications

(39 citation statements)

References 54 publications

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“…2,19,20 Recent cases of CCA have been documented in all regions of the head and neck. 1-8,14-17 Our findings corroborated these data. Although a great proportion of tumors presented in the major salivary glands (37%) in our study, most tumors arose from other regions in the head and neck, particularly in the oral cavity and pharynx.…”

Section: Discussionsupporting

confidence: 90%

“…In addition, these concomitant medical comorbidities may preclude patients from surgical interventions, contributing to worse prognosis. Women and men were affected at a nearly equal rate (0.92:1), a finding that is in contrast with the studies by Hernandez-Prera et al 17 and O’Sullivan-Mejia et al 18 that found female predominance (1.57:1 and 2.67:1, respectively).…”

Section: Discussioncontrasting

confidence: 66%

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Primary Clear Cell Adenocarcinoma of the Head and Neck: A Population‐Based Analysis

Mukdad¹,

Han²,

Badran³

et al. 2020

Otolaryngol.--head neck surg.

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Objective To characterize the epidemiology and clinicopathologic determinants of survival following the diagnosis of clear cell adenocarcinoma in the head and neck region. Study Design Retrospective cohort study. Setting The Surveillance, Epidemiology, and End Results registry (1994 to 2014). Subjects and Methods A total of 173 cases were identified. Study variables included age, sex, race, tumor subsite, tumor stage, tumor grade, surgical excision, and regional and distant metastases. Survival measures included overall survival (OS) and disease-specific survival (DSS). Results Median age at diagnosis was 63 years, 48% were female, and 80.2% were white. Fourteen percent of patients presented with regional lymph node metastases, while 3.3% of patients presented with distant metastases. Most of the tumors presented in the oral cavity, salivary glands, and pharynx. Kaplan-Meier analysis demonstrated OS and DSS of 77.2% and 83.7% at 5 years, respectively. Median OS after diagnosis was 153 months. Bivariate analysis showed that surgical excision was associated with 5-fold increased OS and DSS, whereas advanced age, high tumor grade, advanced stage, larger tumor size, nodal disease, and distant metastases were all significant predictors of decreased OS and DSS. Conclusions Clear cell adenocarcinoma is a rare neoplasm that typically affects white individuals in their early 60s, with a generally favorable prognosis. It most commonly arises in the oral cavity, major salivary glands, and pharynx. Surgical excision is associated with 5-fold survival benefit, whereas advanced age, high tumor grade, advanced stage, nodal disease, and distant metastases are independently associated with worse OS and DSS.

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Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 66%

Primary Clear Cell Adenocarcinoma of the Head and Neck: A Population‐Based Analysis

Mukdad¹,

Han²,

Badran³

et al. 2020

Otolaryngol.--head neck surg.

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show abstract

“…The most common site of involvement is the base of tongue but other minor salivary glands of the oral cavity, such as the palatal mucosa, floor of mouth, and buccal mucosa, can be involved. Although CCC can occasionally show locoregional and even distant metastasis, it is generally considered an indolent tumor with a good prognosis …”

Section: Malignant Neoplasmsmentioning

confidence: 99%

“…Although CCC can occasionally show locoregional and even distant metastasis, it is generally considered an indolent tumor with a good prognosis. 102,143,144 Where described in the literature, CCCs are well-defined with occasional calcifications or focal necrosis. 145,146 These lesions demonstrated only mild irregular enhancement on CT 146 with hypointense T1 signal and heterogeneously isointense T2 signal.…”

Section: Clear Cell Carcinomamentioning

confidence: 99%

The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

Lubin

Song

Zafar

et al. 2019

Diagnostic Cytopathology

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Oncocytic and oncocytoid lesions represent a distinct subset of salivary gland lesions. True oncocytic lesions of the salivary gland are entirely composed of oncocytes. These are characterized by the presence of abundant eosinophilic granules due to the presence of abundant cytoplasmic mitochondria. Oncocytic lesions of the salivary gland include oncocytosis, oncocytoma, and oncocytic carcinoma. In addition to the true oncocytic lesion, there exists another group of salivary gland lesions, which demonstrate cells with abundant and occasionally granular cytoplasm. These are often termed as “oncocytoid” lesions. The recently proposed Milan System for reporting salivary gland cytology clearly states that fine‐needle aspiration specimens representing oncocytic/oncocytoid lesions of salivary gland cannot effectively distinguish between a nonneoplastic lesion, benign and malignant neoplasms. Therefore, most lesions lacking classic cytomorphologic features will be classified under the umbrella diagnostic term of “Salivary Gland Neoplasm of Uncertain Malignant Potential” (SUMP). In this review, we discuss and illustrate key clinicopathologic and radiologic features that can help the practicing cytopathologist narrow down the differential and provide the best management based diagnosis.

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“…Em um estudo mais focado nessa lesão, Milchgrub et al(4), descreveram uma série de casos, enfatizando algumas características histológicas da lesão como a distribuição das células e seu estroma hialino, além de traçar um perfil imunohistoquímico característico. (4) Nesse artigo, a lesão de células claras foi chamada pela primeira vez de carcinoma de células claras hialinizante de glândulas salivares (1,7,8). Mesmo após isso a lesão não foi aceita diretamente pela OMS e só chegou a ser reconhecida como Carcinoma de células claras de glândulas salivares na última classificação de 2017.…”

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Estudo clínico-patológico do carcinoma de células claras de glândula salivar

Rocha¹

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Reappraising hyalinizing clear cell carcinoma: A population‐based study with molecular confirmation

Abstract: Molecularly confirmed HCCC accounted for 2.5% of salivary gland malignancies at our institution. HCCCs are indolent tumors with a propensity for locoregional recurrence. © 2016 Wiley Periodicals, Inc. Head Neck 39: 503-511, 2017.

Cited by 32 publications

References 54 publications

Primary Clear Cell Adenocarcinoma of the Head and Neck: A Population‐Based Analysis

Primary Clear Cell Adenocarcinoma of the Head and Neck: A Population‐Based Analysis

The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

Estudo clínico-patológico do carcinoma de células claras de glândula salivar

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