Rearing conditions and domestication background determine regulation of hippocampal cell proliferation and survival in adulthood – Laboratory CD1 and C57Bl/6 mice versus wild house mice

Schaefers, Andrea T.U.

doi:10.1016/j.neuroscience.2012.10.020

Cited by 19 publications

(20 citation statements)

References 41 publications

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“…Using the same markers, quantitative data have been presented for wild longtailed wood mice (Apodemus sylvaticus [Hauser et al 2009]) and F1 of wild trapped house mice (Mus musculus domesticus ). Using BrdU, cell proliferation was observed in the latter species also by Schaefers (2013). Ki67 and DCX were used in the study of AHN in wild Brown Norway rats (Epp et al 2009), in laboratory-bred Cairo spiny mice (Acomys cahirinus [Amrein et al 2011]), and in wild Southern Africa spiny mice (Acomys spinossissimus), Namaqua rock mice (Micaelamys namaquensis), red veld rats (Aethomys chrysophilus), and Highveld Immunopositive cells in the dentate gyrus of wood mice stained for the proliferation marker Ki67 (A) are found in the subgranular layer between granular cell layer (gcl) and hilus (hi) and are often seen in clusters.…”

Section: Evidence Of Hippocampal Neurogenesis In the Order Rodentiamentioning

confidence: 99%

Adult Hippocampal Neurogenesis in Natural Populations of Mammals

Amrein

2015

Cold Spring Harb Perspect Biol

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This review will discuss adult hippocampal neurogenesis in wild mammals of different taxa and outline similarities with and differences from laboratory animals. It begins with a review of evidence for hippocampal neurogenesis in various mammals, and shows the similar patterns of age-dependent decline in cell proliferation in wild and domesticated mammals. In contrast, the pool of immature neurons that originate from proliferative activity varies between species, implying a selective advantage for mammals that can make use of a large number of these functionally special neurons. Furthermore, rapid adaptation of hippocampal neurogenesis to experimental challenges appears to be a characteristic of laboratory rodents. Wild mammals show species-specific, rather stable hippocampal neurogenesis, which appears related to demands that characterize the niche exploited by a species rather than to acute events in the life of its members. Studies that investigate adult neurogenesis in wild mammals are not numerous, but the findings of neurogenesis under natural conditions can provide new insights, and thereby also address the question to which cognitive demands neurogenesis may respond during selection.

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Section: Evidence Of Hippocampal Neurogenesis In the Order Rodentiamentioning

confidence: 99%

Adult Hippocampal Neurogenesis in Natural Populations of Mammals

Amrein

2015

Cold Spring Harb Perspect Biol

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“…Early-life wheel running also appears to have little effect on adult anxiety-like behavior (Ishikawa et al, 2014). Evidence is similarly sparse and mixed on lasting effects of early-life and prenatal enrichment on adult neurogenesis (Boehme et al, 2011;Schaefers, 2013). Given that the effects of early-life enrichment on neurogenesis and behavior are similarly mixed, this might still indicate parallels.…”

Section: Effects Of Early-life Experiences On Adult Neurogenesis and mentioning

confidence: 99%

Adult Neurogenesis and Mental Illness

Schoenfeld

Cameron

2014

Neuropsychopharmacol

162

108

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Several lines of evidence suggest that adult neurogenesis, the production of new neurons in adulthood, may play a role in psychiatric disorders, including depression, anxiety, and schizophrenia. Medications and other treatments for mental disorders often promote the proliferation of new neurons; the time course for maturation and integration of new neurons in circuitry parallels the delayed efficacy of psychiatric therapies; adverse and beneficial experiences similarly affect development of mental illness and neurogenesis; and ablation of new neurons in adulthood alters the behavioral impact of drugs in animal models. At present, the links between adult neurogenesis and depression seem stronger than those suggesting a relationship between new neurons and anxiety or schizophrenia. Yet, even in the case of depression there is currently no direct evidence for a causative role. This article reviews the data relating adult neurogenesis to mental illness and discusses where research needs to head in the future.

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“…The structural and functional development of hippocampus is susceptible to prenatal or perinatal nutrition (Cintra et al, 1997;Morgane et al, 2002) or stress. Different strains of mice from different rearing condition and domestication background demonstrated differences in hippocampal development (Schaefers, 2013). Moreover, antenatal glucocorticoid treatment reduced BW and hippocampal volume in mice at birth (Noorlander et al, 2014).…”

Section: Discussionmentioning

confidence: 98%

“…The functional disparity of cortisol on hippocampal development is largely determined by the expression and the function of GR in hippocampus. Differences in hippocampus volume/weight imply different cell proliferation and survival patterns in hippocampus (Schaefers, 2013). It has been shown that hippocampal expression of genes involved in cell proliferation and apoptosis differs across rat strains (Neeley et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Breed-specific expression of GR exon 1 mRNA variants and profile of GR promoter CpG methylation in the hippocampus of newborn piglets

Sun

Jia

et al. 2014

Animal

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Glucocorticoid receptor (GR) transcription is driven by alternative promoters to produce different exon 1 mRNA variants. CpG methylation on GR promoters profoundly affects GR transcription. GR in hippocampus is critical for energy homeostasis and stress responses, yet it remains unclear whether hippocampal expression of GR exon 1 mRNA variants and the methylation status of GR promoters differ between Large White (LW) and Erhualian (EHL) pigs showing distinct metabolic and stress-coping characteristics. EHL pigs had higher hippocampus weight relative to BW ( P < 0.01), which was associated with higher serum cortisol level compared with LW pigs. Hippocampal expression of brain-derived neurotrophic factor ( P < 0.05) was significantly higher, while Bax, a pro-apoptotic gene, was significantly lower in EHL pigs ( P < 0.05). Hippocampal expression of total GR did not differ between breeds, yet GR exon 1 to 11 mRNA was significantly higher ( P < 0.01) in EHL pigs, which was associated with a trend of increase ( P = 0.057) in GR protein content. No significant breed difference was detected for the methylation status across the whole region of the proximal GR promoter, while CpG334 and CpG266.267 were differentially methylated, in a reversed manner, between breeds. The methylation status of CpGs 248, 259, 260, 268 and 271 was negatively correlated ( P < 0.05) with GR exon 1 to 11 mRNA abundance. Our results provide fundamental information on the breed-specific characteristics of GR and its mRNA variants expression and the status of DNA methylation on the proximal GR promoter in the pig hippocampus.

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Rearing conditions and domestication background determine regulation of hippocampal cell proliferation and survival in adulthood – Laboratory CD1 and C57Bl/6 mice versus wild house mice

Cited by 19 publications

References 41 publications

Adult Hippocampal Neurogenesis in Natural Populations of Mammals

Adult Hippocampal Neurogenesis in Natural Populations of Mammals

Adult Neurogenesis and Mental Illness

Breed-specific expression of GR exon 1 mRNA variants and profile of GR promoter CpG methylation in the hippocampus of newborn piglets

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