Reasons Women at Elevated Risk of Breast Cancer Refuse Breast MR Imaging Screening: ACRIN 6666

Abstract

Purpose:To determine reasons for nonparticipation in a trial of supplemental screening with magnetic resonance (MR) imaging after mammography and ultrasonography (US). Materials and Methods:Women ( n = 2809) at elevated risk of breast cancer were enrolled in the American College of Radiology Imaging Network 6666 US Screening Protocol at 21 institutions. Fourteen institutions met technical and experience requirements for this institutional review board-approved, HIPAA-compliant substudy of supplemental screening with MR imaging. Those women who had completed 0-, 12-, and 24-month screenings with mammography combined with US were considered for a single contrast materialenhanced MR examination within 8 weeks after completing the 24-month mammography-US screening. A total of 1593 women had complete MR substudy registration data: 378 of them were ineligible for the study, and 1215 had analyzable data. Reasons for nonparticipation were determined. Demographic data were compared between study participants and nonparticipants. Results:Of 1215 women with analyzable data, 703 (57.9%), with a mean age of 54.8 years, were enrolled in the MR substudy and 512 (42.1%) declined participation. Women with a 25% or greater lifetime risk of breast cancer were more likely to participate (odds ratio, 1.53; 95% confidence interval: 1.10, 2.12). Of 512 nonparticipants, 130 (25.4%) refused owing to claustrophobia; 93 (18.2%), owing to time constraints; 62 (12.1%), owing to fi nancial concerns; 47 (9.2%), because their physician would not provide a referral and/or did not believe MR imaging was indicated; 40 (7.8%), because they were not interested; 39 (7.6%), because they were medically intolerant to MR imaging; 29 (5.7%), because they did not want to undergo intravenous injection; 27 (5.3%), owing to additional biopsy or other procedures that might be required subsequently; 21 (4.1%), owing to MR imaging scheduling constraints; 11 (2.2%), because of the travel required; seven (1.4%), owing to gadolinium-related risks or allergies; and six (1.2%), for unknown reasons. Conclusion:Of 1215 women with elevated breast cancer risk who could, according to protocol guidelines, undergo breast MR imaging, only 57.9% agreed to participate.q RSNA, 2010

Three‐dimensional microwave imaging of realistic numerical breast phantoms via a multiple‐frequency inverse scattering technique

“…11 However, there are substantial concerns about high costs and limited access to high-quality MRI services. Furthermore, breast MRI is time-consuming, problematic for claustrophobic 12 or very obese patients, and prohibited for women with pacemakers. Thus, neither mammography nor MRI is ideally suited for evaluating and monitoring breast density.…”

Patient’s Comfort and Technical Quality Exams at 1.5 and 3.0 T Magnetic Resonance Imaging

“…In one study, Berg and colleagues examined the reasons why women with high risk for breast cancer refused breast MRI. Their results showed that even 10.6% (133 of 1215) patients, in whom breast MRI was indicated, were not examined due to claustrophobia [24] and that claustrophobia was the most common reason for unperformed MRI (25.4%).…”

Robust identification of the cancer biomarker phosphocholine through partitioned envelopes in noisy magnetic resonance spectroscopic data by the non-parametric fast Padé transform

“…However, this recommendation can lead to more false-positive findings, and thereafter to further worsening in the specificity of MRI after excisional biopsy [76]. It should be noted that women at high breast cancer risk often turn down invitations to participate in MRI surveillance programs due to fear of being sent for biopsy or other testing [77]. There is a pressing need to improve breast cancer imaging strategies to be better adapted to women's needs, especially their risk profile [78].…”