2019
DOI: 10.3389/fchem.2019.00043
|View full text |Cite
|
Sign up to set email alerts
|

Reassessing the Host Defense Peptide Landscape

Abstract: Current research has demonstrated that small cationic amphipathic peptides have strong potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and anti-inflammatories. Although traditionally termed antimicrobial peptides (AMPs) these additional roles have prompted a shift in terminology to use the broader term host defense peptides (HDPs) to capture the multi-functional nature of these molecules. In this review, we critically examined the role of AMPs and HDPs in infectious dis… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

2
295
0
1

Year Published

2019
2019
2022
2022

Publication Types

Select...
6
1
1

Relationship

1
7

Authors

Journals

citations
Cited by 291 publications
(298 citation statements)
references
References 276 publications
(347 reference statements)
2
295
0
1
Order By: Relevance
“…By understanding how amino acid sequence modulates more than just antibacterial activity, the true therapeutic potential of HDPs could be harnessed. As discussed in detail in Haney et al (2019), recognizing the emerging roles and activity landscape of HDPs will lead to the development of drugs with effectiveness against infectious diseases as well as inflammatory conditions. For nearly 40 years, HDPs have been championed as one of the important tools to combat AMR.…”
Section: Host Defense Peptidesmentioning
confidence: 99%
See 1 more Smart Citation
“…By understanding how amino acid sequence modulates more than just antibacterial activity, the true therapeutic potential of HDPs could be harnessed. As discussed in detail in Haney et al (2019), recognizing the emerging roles and activity landscape of HDPs will lead to the development of drugs with effectiveness against infectious diseases as well as inflammatory conditions. For nearly 40 years, HDPs have been championed as one of the important tools to combat AMR.…”
Section: Host Defense Peptidesmentioning
confidence: 99%
“…However, many of these peptides have more than one function: many AMPs have been shown to possess immunomodulatory, anti-cancer and antibiofilm functions in addition to their antimicrobial properties (Powers and Hancock, 2003;Chan et al, 2006;Hancock and Sahl, 2006;Pletzer and Hancock, 2016;Andrea et al, 2018;Kumar et al, 2019). Indeed, this ability to act on multiple fronts is what makes AMPs attractive (Hancock and Sahl, 2006;Haney et al, 2019) and has led to them being referred to as host defense peptides (HDPs).…”
mentioning
confidence: 99%
“…AMPs have been shown to disrupt the integrity of lipid membranes by mainly using model systems (25). A critical step in the lytic mechanism is the self-assembly of AMPs within bacterial membranes, which is not well characterized at a molecular level (3,26). ssNMR can provide valuable structural information but suffers from low signal-to-noise ratio coupled with limited viability of the bacterial suspension under harsh MAS conditions (5,27).…”
Section: Discussionmentioning
confidence: 99%
“…The antimicrobial properties of host-defense peptides have been extensively studied using model membranes of different lipid compositions that mimic those encountered in prokaryotes and eukaryotes (1). These biophysical studies have provided preliminary insights into the molecular mechanism of antimicrobial peptides (AMPs) and lipid-AMP interactions (2,3). In particular, solid-state NMR (ssNMR) studies have provided critical structural information to better understand the complex interplay between AMPs and bilayer membranes (4,5).…”
mentioning
confidence: 99%
“…It can also be produced in to a lesser extent by macrophages, mucosal epithelium, eosinophils and mast cells. Release of HDP, such as cathelicidin, is a critical part of the first line innate immune response to infection [42,43] and it is antibacterial, antiviral, antifungal and immunomodulatory [44][45][46], with potent ability to modulate the local innate and adaptive immune response. Amongst other effects, it can act as a chemoattractant for immune cells [47,48], promote protective inflammatory responses and modulate cell death [49,50], induce wound healing, re-epithelialization and re-endothelialization [51,52], allow the take-up of self-RNA and production of type one interferons by plasmacytoid DC [53,54] and inhibit class switching in B cells [55].…”
Section: Introductionmentioning
confidence: 99%