Recalcitrant molluscum contagiosum successfully treated with sinecatechins

Padilla-España, L.; Mota-Burgos, A.; Martínez-Amo, J.L.; Benavente-Ortiz, F.; Rodríguez-Bujaldón, A.; Hernández-Montoya, Carlos

doi:10.1111/dth.12338

Cited by 10 publications

(7 citation statements)

References 10 publications

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“…New MC treatments include topical sinecatechins,84 intralesional 5-fluorouracil,85 hyperthermia,86 and zoster immune globulin 87. Evidence is preliminary to determine the effectiveness of these therapies.…”

Section: Treatmentmentioning

confidence: 99%

<p>Molluscum contagiosum: an update and review of new perspectives in etiology, diagnosis, and treatment</p>

Meza‐Romero¹,

Navarrete‐Dechent²,

Downey³

2019

CCID

145

115

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Molluscum contagiosum (MC) is a self-limited infectious dermatosis, frequent in pediatric population, sexually active adults, and immunocompromised individuals. It is caused by molluscum contagiosum virus (MCV) which is a virus of the Poxviridae family. MCV is transmitted mainly by direct contact with infected skin, which can be sexual, non-sexual, or autoinoculation. Clinically, MC presents as firm rounded papules, pink or skin-colored, with a shiny and umbilicated surface. The duration of the lesions is variable, but in most cases, they are self-limited in a period of 6-9 months. The skin lesions may vary in size, shape, and location, which is more frequent in immunosuppressed patients, and could present complications such as eczema and bacterial superinfection. The diagnosis is based on clinical findings. A useful clinical tool is dermoscopy. If the diagnostic doubt persists, confocal microscopy or skin biopsy could be performed. The need for active treatment for MC is controversial; however, there is a consensus that it should be indicated in cases of extensive disease, associated with complications or aesthetic complaints. There are several treatment modalities which include mechanical, chemical, immunomodulatory, and antivirals. The objective of this article is to review the current evidence in etiology, clinical manifestations, diagnosis, and management alternatives of MC.

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Section: Treatmentmentioning

confidence: 99%

<p>Molluscum contagiosum: an update and review of new perspectives in etiology, diagnosis, and treatment</p>

Meza‐Romero¹,

Navarrete‐Dechent²,

Downey³

2019

CCID

145

115

View full text Add to dashboard Cite

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“…Case studies have had positive outcomes with MC lesions treated with dilute povidone iodine with dimethylsulfoxide , subcutaneous interferon alpha , topical cidofovir , sinecatechins ointment , oral cimetidine , and lemon myrtle oil , all of which are detailed in Table . Dilute povidone‐iodine with dimethylsulfoxide applied twice daily to MC lesions on the inner thigh of a 16‐year‐old girl was found to be effective, with half of the lesions resolved within 3 weeks .…”

Section: Miscellaneousmentioning

confidence: 99%

“…Cidofovir was used successfully in the treatment of refractory MC lesions in patients with HIV and Wiskott–Aldrich syndrome . Sinecatechins ointment (10% applied twice daily for 4 wks) also reduced refractory MC lesions in a 4‐year‐old girl . Oral cimetidine treatment for 2 months (40 mg/kg/day) reduced MC lesions in 13 children .…”

Section: Miscellaneousmentioning

confidence: 99%

Molluscum Contagiosum: Review and Update on Management

Forbat

Al‐Niaimi

Ali

2017

Pediatric Dermatology

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Molluscum contagiosum (MC) is an infectious dermatosis that commonly presents in children and immunocompromised individuals. Although lesions usually resolve spontaneously after several months, they can be symptomatic and cause psychosocial distress. We review the evidence underlying treatment methods available for MC lesions, including potassium hydroxide, salicylic acid, hydrogen peroxide, retinoids, cantharidin, cryotherapy, curettage, and pulsed dye laser to aid practicing dermatologists in therapy selection.

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“…[17] e therapeutic effects of sinecatechins in cutaneous infections are attributed to their immunomodulatory, antioxidant, and antiviral properties. [2] e beneficial effect of zinc is believed to be due to its effects on macrophage and neutrophil functions, natural killer cell/phagocytic activity, and various cytokines. [13] e various vaccines act by boosting cell-mediated immunity, while IFN α-2b shows antiviral activity through viral interference.…”

Section: Mechanism Of Action: An Overviewmentioning

confidence: 99%

“…[1] Molluscum contagiosum, recurrent herpes labialis, and genitalis and cutaneous leishmaniasis are the other cutaneous infections where immunotherapy is found effective. [2][3][4][5][6][7][8][9][10] is review focuses on the topical/intralesional agents used in cutaneous infections. e common topical agents used are imiquimod 5% cream, diphenylcyclopropenone (DPCP) (diphencyprone), squaric acid dibutyl ester (SADBE), 15% sinecatechins ointment, Bacillus Calmette-Guerin (BCG) vaccine in normal saline or salicylic acid, and 15% zinc ointment.…”

Section: Introductionmentioning

confidence: 99%

Topical and intralesional immunotherapy in cutaneous infections

Chandran¹

2022

JSSTD

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Immunotherapy has revolutionized the treatment of extensive and resistant warts. Promising results have extended the role of immunotherapy to other infections such as extensive molluscum contagiosum, recurrent herpes simplex infections, and cutaneous leishmaniasis, which are resistant to standard treatment. This review focuses on topical and intralesional immunotherapy in the management of cutaneous infections.

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Recalcitrant molluscum contagiosum successfully treated with sinecatechins

Cited by 10 publications

References 10 publications

<p>Molluscum contagiosum: an update and review of new perspectives in etiology, diagnosis, and treatment</p>

<p>Molluscum contagiosum: an update and review of new perspectives in etiology, diagnosis, and treatment</p>

Molluscum Contagiosum: Review and Update on Management

Topical and intralesional immunotherapy in cutaneous infections

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