Recalcitrant viral warts treated with photodynamic therapy methyl aminolevulinate and red light (630 nm): a case series of 51 patients

Alcántara‐González, J.; Calzado-Villarreal, Leticia; Sánchez-Largo, Maria Elena; Andreu-Barasoain, Marta; Salado, Marta Ruano-Del

doi:10.1007/s10103-019-02823-3

Cited by 9 publications

(2 citation statements)

References 6 publications

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“…5-Aminolevulinic acid (ALA), methyl aminolevulinate (MAL; Metvix), and Hexvix/Cysview are precursors of protoporphyrin IX, which absorbs at 630 nm [ 28 , 29 ]. They were granted FDA approvals and are used to treat glioblastoma, basal cell carcinoma, Bowen disease, prostate, bladder, and colon cancers [ 30 , 31 , 32 ]. Meta-tetrahydroxy phenyl chlorin (m-THPC, temoporfin), excitation wavelength of ~652 nm, is approved in the EU to treat biliary and pancreatic cancers and breast cancer metastases.…”

Section: Photodynamic Therapy In Treating Cancermentioning

confidence: 99%

Liposome Photosensitizer Formulations for Effective Cancer Photodynamic Therapy

2021

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Photodynamic therapy (PDT) is a promising non-invasive strategy in the fight against that which circumvents the systemic toxic effects of chemotherapeutics. It relies on photosensitizers (PSs), which are photoactivated by light irradiation and interaction with molecular oxygen. This generates highly reactive oxygen species (such as 1O2, H2O2, O2, ·OH), which kill cancer cells by necrosis or apoptosis. Despite the promising effects of PDT in cancer treatment, it still suffers from several shortcomings, such as poor biodistribution of hydrophobic PSs, low cellular uptake, and low efficacy in treating bulky or deep tumors. Hence, various nanoplatforms have been developed to increase PDT treatment effectiveness and minimize off-target adverse effects. Liposomes showed great potential in accommodating different PSs, chemotherapeutic drugs, and other therapeutically active molecules. Here, we review the state-of-the-art in encapsulating PSs alone or combined with other chemotherapeutic drugs into liposomes for effective tumor PDT.

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Section: Photodynamic Therapy In Treating Cancermentioning

confidence: 99%

Liposome Photosensitizer Formulations for Effective Cancer Photodynamic Therapy

2021

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“…( B ) Untreated left retro-auricular area. Clinical indications for PDT are increasingly growing within the literature, and one of these indications is to treat verrucae [ 9 , 11 , 12 , 13 ]. It is clear that the regression rate of this sort of lesion is very variable.…”

Section: Figuresmentioning

confidence: 99%

Photodynamic Therapy Used to Treat an HIV Patient with an Efflorescence of Viral Warts after HAART Therapy

et al. 2023

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Healing from viral warts lesions can be hard to achieve in immunocompromised subjects like HIV-positive patients. The therapeutic target in immunocompetent subjects can be reached using different methods, including topical ointments, cryotherapy, laser therapy, imiquimod, and photodynamic therapy (PDT). We present a case of a male HIV-positive patient who came to the Dermatology department with multifocal wart lesions on his face, auricular, and retro-auricular areas after treatment with highly active antiretroviral therapy (HAART). In our case, surprisingly, only one session of PDT proved to induce complete regression of lesions which, despite their thickness, had a much more robust response to treatment than we could have possibly expected. After a brief review of the literature, it is possible to state that PDT revealed itself to be a valid option in immunocompromised patients who have a major risk of relapse.

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Enhanced Photodynamic Therapy

Li¹,

Lin²

2023

Biomedical Photonic Technologies

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Recalcitrant viral warts treated with photodynamic therapy methyl aminolevulinate and red light (630 nm): a case series of 51 patients

Cited by 9 publications

References 6 publications

Liposome Photosensitizer Formulations for Effective Cancer Photodynamic Therapy

Liposome Photosensitizer Formulations for Effective Cancer Photodynamic Therapy

Photodynamic Therapy Used to Treat an HIV Patient with an Efflorescence of Viral Warts after HAART Therapy

Enhanced Photodynamic Therapy

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