Recent Advancement in Synthesis and Bioactivities of 1,3,4-Oxadiazole

Abstract

Derivatives of 1,3,4-oxadiazole are effective in the treatment and cure of a wide range of diseases in medical chemistry, while industrial development has shown that they can be utilised as corrosion inhibitors and light-emitting diodes. The researchers discovered several promising synthetic strategies that created 1,3,4-oxadiazoles in extraordinarily high yields while using environmentally friendly methods. These compounds can potentially be used in a wide range of life-changing applications. Stable isomeric oxadiazole forms of pleconaril, raltegravir, butalamine, fasiplon, oxolamine, and several other drugs are among the numerous potent and effective pharmaceuticals that are now on the market. Fasiplon, butalamine, raltegravir, and pleconaril treat HIV/AIDS patients. This article has attempted to bring attention to the chemistry and pharmacology of oxadiazole and its derivatives. Oxadiazole derivatives have been used extensively as prospective therapeutic agents in clinical research, and this has become standard practice. The use of biological and in-silico models has enabled scientists to identify more synthetic analogues of cancer prevention, antifungal, and anti-HIV medications. This article provides recent information regarding procedures synthesizing 1,3,4-oxadiazoles and their biological actions on the body.

Mechanistic Investigation of Thiazole-Based Pyruvate Kinase M2 Inhibitor Causing Tumor Regression in Triple-Negative Breast Cancer

“…Notably, imidazopyridines are found in drugs such as zolpidem and alpidem . Imidazopyrimidines play a role in medications like divaplon and fasiplon. , Thiazoles, on the other hand, are associated with drugs like dabrafenib, dasatinib, and tiazofurin, serving as integral components in these approved anticancer drugs. − Furthermore, the PKM2 inhibitor TLSC702 incorporates thiazole as a crucial part of its structure …”