Recent Advancements and Biological Activities of Aryl Propionic Acid Derivatives: A Review

Dhall, Harshita; Sikka, Pratiksha; Kumar, Arvind; Mishra, Arun Kumar

doi:10.13005/ojc/320411

Cited by 8 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is preferred in the treatment of pain associated with osteoarthritis, rheumatoid arthritis and ankylosingspondilytis 64 .…”

Section: Fenoprofenmentioning

confidence: 99%

“…Studies on the structure-activity relationship (SAR) were conducted on 3-aryl propionic acids as selective agonists by introducing substituents to the chain of propionic acid the adjacent phenyl ring with pyridine chain was replaced to develop a series of containing modified 3-aryl propionic acids with an enhanced half-life in rat 30,64,65 . The important members of this class, ibuprofen, naproxen, and Ketoprofen are now available as OTC medicines.…”

Section: Oxaprozinmentioning

confidence: 99%

See 1 more Smart Citation

Untitled

2020

IJPSR

View full text Add to dashboard Cite

Arylpropionic acid derivatives are an important class of NSAIDs. Ibuprofen, 2-(4-isobutylphenyl) propionic acid, is known as NSAIDs. Arylpropionic acid derivatives have a broad biological activity, including antibacterial, anticonvulsant and anticancer activity, analgesic, and anti-inflammatory. In addition to the most powerful ingredients used in analgesic and antipyretic fields, such as ibuprofen, Oxaprozin, Ketoprofen, and Phenoprofen, aryl propionic acid derivatives play an important role in treating other symptoms. The possible improvements in the activity can be further achieved by slight modifications in the substituent on the basic aryl propionic acid. According to Grigoryan et al., 2019 studies reveal that the replacement of the carboxyl group by tetrazole ring, hydroxamate, ester, alcohol, and amide groups forms compound showing lower activity (antiinflammatory, anti-nociceptive, ulcerogenic activity). The presence of a carboxyl group in the parent molecule of aryl propionic acid is important for broad-spectrum pharmacological activity. This review focused on recent advances and recent research on aryl propionic acid derivatives compared to medicinal chemistry. INTRODUCTION: Medical chemistry is an area that determines the effect of chemical composition on biological activity. Medical chemistry has been expanded with the help of experimental methods for predicting the composition of new compounds that rely heavily on structural changes and the determination of biological properties.

show abstract

“…It is preferred in the treatment of pain associated with osteoarthritis, rheumatoid arthritis and ankylosingspondilytis 64 .…”

Section: Fenoprofenmentioning

confidence: 99%

Section: Oxaprozinmentioning

confidence: 99%

Untitled

2020

IJPSR

View full text Add to dashboard Cite

show abstract

“…The propionic acid part present in compounds showed a wide range of biological importance. The aryl propionic acid with chiral centre on 2 nd carbon was reported by many workers but in the present work, we have developed compounds having a chiral centre on 3 rd carbon as shown in Figure .…”

Section: Introductionmentioning

confidence: 99%

Rapid and Efficient Approaches for Synthesis of Some New Aryl Propionic Acid Derivatives and In–Vivo Anti‐Diabetic Screening of Selected Compounds

et al. 2019

View full text Add to dashboard Cite

A series of some new aryl propionic acid derivatives as 2‐(6‐(substituted phenylethynyl)‐2,3‐dihydrobenzofuran‐3‐yl)acetic acids were synthesized. The targeted molecules were prepared by using techniques such as efficient and high‐performance autoclave hydrogenation to reduce highly stable π‐electron system of furan ring and microwave‐assisted rapid Sonogashira Cross‐Coupling reaction between aryl triflate derivatives and substituted aryl acetylenes. The anti‐diabetic screening of selected compounds was performed by using alloxan‐induced diabetic model. The studies include acute and chronic toxicity, effectiveness, change in the behavioral pattern and change in glucose level of the tested animals. The compound 2‐(6‐((4‐ethylphenyl)ethynyl)‐2,3‐dihydrobenzofuran‐3‐yl)acetic acid exhibited maximum anti‐hyperglycemic properties. All the synthesized compounds were characterized by spectroscopic techniques such as 1H‐NMR, 13C‐NMR, IR, Mass spectrometry and single crystal XRD (MTS‐201).

show abstract

“…In the present scenario, health problems demand to synthesize and investigate a novel class of antimicrobial agent proved to be active against microbes that are resistant toward currently used antibiotics [7]. TheJrefore, considering the pharmacological potential of aryl propioninc acid derivatives [8][9][10][11][12], novel derivatives of substituted 3,3-diphenyl propanamide were synthesized and investigated for their antibacterial, antifungal, and anthelmintic activity against housefly worms and earthworm species.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Investigation of Anthelmintic, Antibacterial and Antifungal Activity of 3,3-Diphenyl Propanamide Derivatives

Chaudhary¹,

Verma²,

Gupta³

et al. 2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: A novel series of substituted 3,3-diphenyl propanamide derivatives (I-VIII) were synthesized by reacting 3,3-diphenyl propanoyl chloride with different amines/amino acids, and all the derivatives were investigated for anthelmintic, antibacterial, and antifungal activity.Methods: All the compounds were characterized by infrared (IR) and1H- nuclear magnetic resonance spectrometry data. The synthesized derivatives were investigated for their anthelmintic activity employing housefly worms method and earthworm species model. The antibacterial and antifungal activity was performed employing cup plate method.Results: The synthesized compounds (VII and VIII) exhibited maximum anthelmintic activity as compared with standard drug albendazole at doses of 50 and 100 mg/mL, due to minimal paralyzing and death time in both housefly and earthworm models. The compounds (IV, VII, and VIII) at 50 μg/mL exhibited maximum activity against Gram-negative bacterial strains, namely, Escherichia coli, Pseudomonas aeruginosa as compared with ciprofloxacin and same compounds exhibited maximum antifungal activity against Candida albicans and Aspergillus niger in comparison with standard drug griseofulvin at 50 μg/mL.Conclusion: The synthesized compounds bearing amino acid moiety in their structure (VII-VIII) exhibited impressive anthelmintic activity in comparison with albendazole. This suggests that amino acid/peptide derivative of diphenyl propanamides can act as great anthelmintic agents. Further, the research can be performed to design potent antimicrobial diphenyl propanamide derivatives.

show abstract

Recent Advancements and Biological Activities of Aryl Propionic Acid Derivatives: A Review

Cited by 8 publications

References 15 publications

Untitled

Untitled

Rapid and Efficient Approaches for Synthesis of Some New Aryl Propionic Acid Derivatives and In–Vivo Anti‐Diabetic Screening of Selected Compounds

Synthesis and Investigation of Anthelmintic, Antibacterial and Antifungal Activity of 3,3-Diphenyl Propanamide Derivatives

Contact Info

Product

Resources

About