Recent advancements in bioelectronic devices to interface with the peripheral vestibular system

Moshizi, S.A.; Pastras, Christopher J.; Sharma, Rajni; Mahmud, Arafat; Ryan, Rachel; Razmjou, Amir; Asadnia, Mohsen

doi:10.1016/j.bios.2022.114521

Cited by 7 publications

(12 citation statements)

References 72 publications

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“…Implantable sensors have been developed to monitor inner ear function, detect hearing loss, and diagnose balance disorders. 123,124 These sensors can be used to measure cochlear pressure, inner ear fluid levels, and acoustic signals. Cochlear implants, for example, are electronic medical devices that replace the functions of a damaged inner ear and help individuals with severe hearing loss to hear again.…”

Section: Types and Applications Of Implantable Sensors: An Overviewmentioning

confidence: 99%

Current state of the art and future directions for implantable sensors in medical technology: Clinical needs and engineering challenges

Yogev,

Goldberg,

Arami

et al. 2023

APL Bioengineering

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Implantable sensors have revolutionized the way we monitor biophysical and biochemical parameters by enabling real-time closed-loop intervention or therapy. These technologies align with the new era of healthcare known as healthcare 5.0, which encompasses smart disease control and detection, virtual care, intelligent health management, smart monitoring, and decision-making. This review explores the diverse biomedical applications of implantable temperature, mechanical, electrophysiological, optical, and electrochemical sensors. We delve into the engineering principles that serve as the foundation for their development. We also address the challenges faced by researchers and designers in bridging the gap between implantable sensor research and their clinical adoption by emphasizing the importance of careful consideration of clinical requirements and engineering challenges. We highlight the need for future research to explore issues such as long-term performance, biocompatibility, and power sources, as well as the potential for implantable sensors to transform healthcare across multiple disciplines. It is evident that implantable sensors have immense potential in the field of medical technology. However, the gap between research and clinical adoption remains wide, and there are still major obstacles to overcome before they can become a widely adopted part of medical practice.

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Section: Types and Applications Of Implantable Sensors: An Overviewmentioning

confidence: 99%

Current state of the art and future directions for implantable sensors in medical technology: Clinical needs and engineering challenges

Yogev,

Goldberg,

Arami

et al. 2023

APL Bioengineering

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“…Gyroscopes and accelerometers are now so sensitive that they can detect head movements in microgravity ( Sadovnichii et al, 2018 ). It is worth noting that recent advances in biomimetic SCC and otolithic organs development can improve the sensing capability of prosthetic devices, and because of their mechanical behavior, their output sensitivity and frequency selectivity will be analogous to natural systems producing a more reliable operation of prosthetic devices with less computational processing demand ( Raoufi et al, 2019 ; Jiang et al, 2022 ; Moshizi et al, 2022 ).…”

Section: Prosthesis Designmentioning

confidence: 99%

Vestibular prosthesis: from basic research to clinics

Soto

Pliego

Vega

2023

Front. Integr. Neurosci.

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Balance disorders are highly prevalent worldwide, causing substantial disability with high personal and socioeconomic impact. The prognosis in many of these patients is poor, and rehabilitation programs provide little help in many cases. This medical problem can be addressed using microelectronics by combining the highly successful cochlear implant experience to produce a vestibular prosthesis, using the technical advances in micro gyroscopes and micro accelerometers, which are the electronic equivalents of the semicircular canals (SCC) and the otolithic organs. Reaching this technological milestone fostered the possibility of using these electronic devices to substitute the vestibular function, mainly for visual stability and posture, in case of damage to the vestibular endorgans. The development of implantable and non-implantable devices showed diverse outcomes when considering the integrity of the vestibular pathways, the device parameters (current intensity, impedance, and waveform), and the targeted physiological function (balance and gaze). In this review, we will examine the development and testing of various prototypes of the vestibular implant (VI). The insight raised by examining the state-of-the-art vestibular prosthesis will facilitate the development of new device-development strategies and discuss the feasibility of complex combinations of implantable devices for disorders that directly affect balance and motor performance.

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“…For detailed information, a comprehensive study has been conducted on bioelectronic devices to interface with the peripheral vestibular system in Ref. [12]. Taking inspiration from sensory hair cells is a well-established technique to fabricate flow sensors for a broad range of applications such as microfluidic devices [13], leakage detection systems [14], navigation systems [15] and respiratory monitoring [16] to measure flow velocity and frequency.…”

Section: Introductionmentioning

confidence: 99%

“…It is no surprise the elegance and simplicity of the biological transduction apparatus (the hair bundle/cell system) has inspired engineers looking to fabricate sensitive signal detection systems over a range of research fields, from underwater sensing [17], force de- It is no surprise the elegance and simplicity of the biological transduction apparatus (the hair bundle/cell system) has inspired engineers looking to fabricate sensitive signal detection systems over a range of research fields, from underwater sensing [17], force detection [18], to respiratory flow sensing [19]. However, another promising future application lies in the development of artificial biomimetic hair cells as replacements of damaged inner ear sensory systems in health and disease [12]. In principle, such a device may serve as an inner ear prosthesis.…”

Section: Introductionmentioning

confidence: 99%

Artificial Hair Cell Sensor Based on Nanofiber-Reinforced Thin Metal Films

A. Moshizi,

Pastras,

Peng

et al. 2024

Biomimetics

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Engineering artificial mechanosensory hair cells offers a promising avenue for developing diverse biosensors spanning applications from biomedicine to underwater sensing. Unfortunately, current artificial sensory hair cells do not have the ability to simultaneously achieve ultrahigh sensitivity with low-frequency threshold detection (e.g., 0.1 Hz). This work aimed to solve this gap by developing an artificial sensory hair cell inspired by the vestibular sensory apparatus, which has such functional capabilities. For device characterization and response testing, the sensory unit was inserted in a 3D printed lateral semicircular canal (LSCC) mimicking the environment of the labyrinth. The sensor was fabricated based on platinum (Pt) thin film which was reinforced by carbon nanofibers (CNFs). A Pi-shaped hair cell sensor was created as the sensing element which was tested under various conditions of simulated head motion. Results reveal the hair cell sensor displayed markedly higher sensitivity compared to other reported artificial hair cell sensors (e.g., 21.47 mV Hz−1 at 60°) and low frequency detection capability, 0.1 Hz < f < 1.5 Hz. Moreover, like the LSCC hair cells in biology, the fabricated sensor was most sensitive in a given plane of rotational motion, demonstrating features of directional sensitivity.

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Recent advancements in bioelectronic devices to interface with the peripheral vestibular system

Cited by 7 publications

References 72 publications

Current state of the art and future directions for implantable sensors in medical technology: Clinical needs and engineering challenges

Current state of the art and future directions for implantable sensors in medical technology: Clinical needs and engineering challenges

Vestibular prosthesis: from basic research to clinics

Artificial Hair Cell Sensor Based on Nanofiber-Reinforced Thin Metal Films

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