Recent advancements in microfluidics that integrate electrical sensors for whole blood analysis

Abstract

<p>In this paper, we review recent advancements in microfluidics that integrate electrical sensors for whole blood analysis. Besides summarizing the features of related work, we also discuss potential challenges that need to be addressed.</p>

A platinum glutamate acid complex as a peroxidase mimic: high activity, controllable chemical modification, and application in biosensors

“…Cholesterol, a vital compound, plays a pivotal role in health, with abnormal levels leading to various diseases, 19 including hyperlipidemia, 20 atherosclerosis, 21 and anemia. 22 ALP, present in various human tissues and organs, undergoes alterations in response to diseases associated with these tissues or organs. 23,24 These markers signicantly contribute to evaluating liver function and overall health.…”

Non-invasive monitoring of biochemicals in hydrogel-assisted microfluidic chips

“…10,11 Invasive methods have advantages of high sensitivity and fast response, but embedded sensors inevitably affect the fluidic sample or largely complicate the manufacturing process due to the high bonding requirement at the interface. 12,13 To minimize the influence of characterization sensors on the flow inside microfluidic chips, optical methods have gained increasing attention over the last few decades due to their non-invasive nature. Ultraviolet-visible absorption, 14 Fourier transform infrared spectroscopy, 15 fluorescence spectroscopy 16 and Raman spectroscopy 17,18 are typical optical sensing methods for molecules and ions.…”

Microfluidic systems for the analysis of blood‐derived molecular biomarkers

“…Other reviews on microfluidic platforms for biomarker analysis have a more focused scope, which either center on the detection of biomarkers such as carbohydrates, lipids, proteins, nucleic acids [39,43], prostate cancer [38], or electrical sensors for whole blood analysis [44]. Other reviews focus on integrated microfluidic devices that integrate whole blood sample preparation and separation techniques for the detection of proteins, peptides, lipid vesicles, DNA, or amino acids [42].…”