Recent Advancements in Nanocarrier-assisted Brain Delivery of Phytochemicals Against Neurological Diseases

Mishra, K K; Rana, Rafquat; Tripathi, Shourya; Siddiqui, Shumaila; Yadav, Pavan; Yadav, Prem N.; Chourasia, Manish K.

doi:10.1007/s11064-023-03955-3

Cited by 3 publications

References 188 publications

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The Role of Nanomaterials in Diagnosis and Targeted Drug Delivery

Veg,

Hashmi,

Raza

et al. 2024

Chemistry & Biodiversity

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Nanomaterials owing to their small size imparts them with unique properties and they can also be designed and engineered according to the specific need. The use of nanoparticles (NPs) in medicine is particularly revolutionary as it has opened new therapeutic avenues to diagnose, treat and manage diseases in an efficient and timely manner. The review article presents the biomedical applications of nanomaterials including bioimaging, magnetic hypothermia and photoablation therapy, with a particular focus on disease diagnosis and targeted drug delivery. Nanobiosensors are highly specific and can be delivered into cells to investigate important biomarkers. They are also used for targeted drug delivery and deliver theranostic agents to specific sites of interest. The review also explores the role of nano‐based drug delivery systems for the management and treatment of nervous system disorders, tuberculosis and orthopaedics. The nano‐capsulated drugs can be transported by blood to the targeted site for a sustained release over a prolonged period. Some other applications like their role in invasive surgery, photodynamic therapy and quantum dot imaging have also been explored. Despite that, the safety concerns related to nanomedicine should be comprehended as well as the biodistribution of NPs in the body and the mechanistic insight.

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The Role of Nanomaterials in Diagnosis and Targeted Drug Delivery

Veg,

Hashmi,

Raza

et al. 2024

Chemistry & Biodiversity

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Revolutionizing neurotherapeutics: Nanocarriers unveiling the potential of phytochemicals in Alzheimer's disease

Kamath,

Nayak,

John

et al. 2024

Neuropharmacology

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Anti Alzheimer’s effects of Neem oil nanoemulsion against Amyloid β_1-40induced in human neuroblastoma SH-SY5Y cell line

Govindaswamy

2024

Preprint

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Alzheimers disease is characterized by cognitive decline associated with neurodegeneration and accumulation of amyloid beta. Here, experimenting with in vitro models of AD using SHSY5Y cell line after exposing them with Aβ1-40. The natural derivatives like neem oil, plays a potential role in neuroprotection and reduction of tau aggregates in animal models, eventually becoming a alternative treatment beneficiaries in neurodegenerative disease. Formulating the neem oil into a nanoemulsion with Tween 80® and Brij 30™ for stabilization, can be a beneficial drug development for AD. The optimization of this neem oil nanoemulsion was performed with Response Surface Methodology - Box Behnken Design, showed the S mix 10, Sonication power 55%, and Sonication time 15%; as the optimized value to synthesize a stable neem oil nanoemulsion. Secondly, they subjected to thermodynamic stability analysis for estimating the shelf life duration with different temperature conditions. Amyloid beta induced SHSY5Y tend to show severe cell oxidative stress, to estimate that, the neem oil and neem oil nanoemulsion were subjected to DPPH assay. Further, the neem oil and neem oil nanoemulsion analyzed with the Aβ1-40 induced SHSY5Y, resulted in good cytotoxicity, where the nanoemulsion exhibited more reduction in cell viability than neem oil. This trend shows that synthesizing the natural oils into nanocarriers can potentially increase the drug release rate, enhanced stability and good biomedical application.

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Recent Advancements in Nanocarrier-assisted Brain Delivery of Phytochemicals Against Neurological Diseases

Cited by 3 publications

References 188 publications

The Role of Nanomaterials in Diagnosis and Targeted Drug Delivery

The Role of Nanomaterials in Diagnosis and Targeted Drug Delivery

Revolutionizing neurotherapeutics: Nanocarriers unveiling the potential of phytochemicals in Alzheimer's disease

Anti Alzheimer’s effects of Neem oil nanoemulsion against Amyloid β_1-40induced in human neuroblastoma SH-SY5Y cell line

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Recent Advancements in Nanocarrier-assisted Brain Delivery of Phytochemicals Against Neurological Diseases

Cited by 3 publications

References 188 publications

The Role of Nanomaterials in Diagnosis and Targeted Drug Delivery

The Role of Nanomaterials in Diagnosis and Targeted Drug Delivery

Revolutionizing neurotherapeutics: Nanocarriers unveiling the potential of phytochemicals in Alzheimer's disease

Anti Alzheimer’s effects of Neem oil nanoemulsion against Amyloid β1-40induced in human neuroblastoma SH-SY5Y cell line

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Product

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Anti Alzheimer’s effects of Neem oil nanoemulsion against Amyloid β_1-40induced in human neuroblastoma SH-SY5Y cell line