Recent Advancements in Omega Fatty Acids to Treat Neurodegeneration

Transcriptomic and metabolomic analyses provide insights into the attenuation of neuroinflammation by nervonic acid in MPTP-stimulated PD model mice

“…56–58 Long-chain unsaturated fatty acids of the neuronal membrane structural components have an impact on cellular function and membrane characteristics, and serve as a source of lipid-derived messengers. 59 Preclinical studies show that omega-3 polyunsaturated fatty acids (n-3 PUFAs) improve cognition, promote neuroprotection (and possibly neurorestoration), reduce neuroinflammation, and alter neuronal function. 60 Based on the above, as a long-chain unsaturated fatty acid, nervonic acid may participate in the metabolism of arachidonic acid, oleic acid or some unsaturated fatty acids, and the decline of dopamine metabolites in this process indicates that inflammation is inhibited and neural plasticity is enhanced.…”