Recent advancements in optical biosensors for cancer detection

Kaur, Baljinder; Kumar, Santosh; Kaushik, Brajesh Kumar

doi:10.1016/j.bios.2021.113805

Cited by 242 publications

(90 citation statements)

References 77 publications

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“…This structure has a number of disadvantages, including a bulky structure and moving components. On the other hand, fiber structure has been developed recently 6 and it has the advantages of low EM interference, small sizes, multiplexing, and remote sensing capabilities, and it could be preferable over the prism structure. 6 …”

Section: Resultsmentioning

confidence: 99%

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Au-Based Thin-Film Metallic Glasses for Propagating Surface Plasmon Resonance-Based Sensor Applications

2022

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We deposited Au–Cu–Si, an Au-based thin-film metallic glass (TFMG) of ∼50 nm thickness, as the activation layer for propagating surface plasmon resonance (PSPR)-based sensors on a BK7 glass substrate to substitute the commonly used gold layer. The film composition was tuned to yield the maximum Au content (∼65 at %), while the structure remained amorphous. The results showed that the Au-based TFMG could support surface plasmon resonance and gave rise to the extinction in the angle-resolved reflection spectrum. Using deionized water and ethyl alcohol with the refractive index difference of ∼0.03 as the analytes, the angle shift given by Au-based TFMG was 4° compared to 5° given by the Au film. Hence, Au-based TFMG is feasible to be used as the activation layer in PSPR-based sensors. Compared to the Au film, Au-based TFMG has the advantages of being less expensive, lacking grain boundary scattering, better adhesion to the substrate, and higher resistance to scratch and corrosion because of its amorphous structure with excellent mechanical properties.

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Section: Resultsmentioning

confidence: 99%

“… 1 , 21 − 23 Thus, noble metals, such as gold and silver have been commonly used as the substrates of SPR-based sensors. Compared with silver, gold has an inert nature with higher chemical stability and direct functionalization 6 with excellent sensitivity to the change of refractive index of the dielectric medium.…”

Section: Introductionmentioning

confidence: 99%

Au-Based Thin-Film Metallic Glasses for Propagating Surface Plasmon Resonance-Based Sensor Applications

2022

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“…Overall, then, results suggest that new directions, such as optical biosensors that are rapid, real-time, and portable technology, have a low detection limit and a high sensitivity, and have a great potential for diagnosing various types of cancer. Optical biosensors can detect cancer in a few million malignant cells, in comparison to conventional diagnosis techniques that use 1 billion cells in tumor tissue with a diameter of 7 nm–10 nm (traditional methods that are also costly, inconvenient, complex, time consuming, and require technical specialists; Kaur et al, 2022). Moreover, the cancer biomarkers using luminescence and electrochemical Metal-organic framework sensors have been opening the way for personalized patient treatments and the development of new cancer-detecting devices (Mohan et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…The goal of this study is an exploratory analysis to detect main sensor technologies applied in cancer research for improving diagnosis and treatments and reducing whenever possible mortality between countries. The vast literature in these topics shows main results for cancer research (Bayford et al, 2022; Kaur et al, 2022; Li et al, 2020, 2020a; Rey-Barth et al, 2022; Sivanandhan et al, 2022; Thakare et al, 2022). As far as breast cancer is concerned, Wu et al (2022) design a dual-aptamers functionalized gold for classification of breast cancer based on Förster resonance energy transfer, which is potentially useful for quantitative classification of different subtypes of breast cancer.…”

Section: Introduction and Goal Of Investigationmentioning

confidence: 99%

Sensor Technology for Opening New Pathways in Diagnosis and Therapeutics of Breast, Lung, Colorectal and Prostate Cancer

Roshani

Coccia

Mosleh

2022

Preprint

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This study analyzes the interaction between sensor research and technology and different types of cancer (breast, lung, colorectal and prostate) that generates a high mortality in society with the goals of detecting new directions for improving diagnosis and therapeutics. This study develops an approach of computational scientometrics based on data of the Web of Science from 1991 to 2021 period. The results of this analysis show the vital role of biosensor and electrochemical biosensor applied in breast cancer, lung cancer, and prostate cancer research, except colorectal cancer for latter one. Instead, research of optical sensors is developing mainly in the directions of breast, prostate, and colorectal cancer for improving diagnostics. Finally, oxygen sensor research is developing for breast and lung cancer for applications in breath analysis in new treatment processes. Preliminary results presented here clearly illustrate the evolutionary paths of main sensor technologies that have a great potential in future diagnosis of cancer, but we also need additional examinations of other aspects and factors for supporting appropriate strategies of management of technology to foster the technology transfer of sensor technologies in cancer research for improving diagnosis and, whenever possible, reduce world-wide mortality of cancer ins society.

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“…This is because they can probe for different targets, for example metal ions, small and macro molecules, and even cells with high selectivity and sensitivity. Biosensors are the analytical devices which modulates the signal obtained from the interaction between the biorecognition element (BRE) and the target molecule [ 18 , 19 ]. When aptamers are used as a BRE in biosensors to track a specific target or biomarker, an aptasensor is formed.…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

et al. 2022

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Viral infections are becoming the foremost driver of morbidity, mortality and economic loss all around the world. Treatment for diseases associated to some deadly viruses are challenging tasks, due to lack of infrastructure, finance and availability of rapid, accurate and easy-to-use detection methods or devices. The emergence of biosensors has proven to be a success in the field of diagnosis to overcome the challenges associated with traditional methods. Furthermore, the incorporation of aptamers as bio-recognition elements in the design of biosensors has paved a way towards rapid, cost-effective, and specific detection devices which are insensitive to changes in the environment. In the last decade, aptamers have emerged to be suitable and efficient biorecognition elements for the detection of different kinds of analytes, such as metal ions, small and macro molecules, and even cells. The signal generation in the detection process depends on different parameters; one such parameter is whether the labelled molecule is incorporated or not for monitoring the sensing process. Based on the labelling, biosensors are classified as label or label-free; both have their significant advantages and disadvantages. Here, we have primarily reviewed the advantages for using aptamers in the transduction system of sensing devices. Furthermore, the labelled and label-free opto-electrochemical aptasensors for the detection of various kinds of viruses have been discussed. Moreover, numerous globally developed aptasensors for the sensing of different types of viruses have been illustrated and explained in tabulated form.

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Recent advancements in optical biosensors for cancer detection

Cited by 242 publications

References 77 publications

Au-Based Thin-Film Metallic Glasses for Propagating Surface Plasmon Resonance-Based Sensor Applications

Au-Based Thin-Film Metallic Glasses for Propagating Surface Plasmon Resonance-Based Sensor Applications

Sensor Technology for Opening New Pathways in Diagnosis and Therapeutics of Breast, Lung, Colorectal and Prostate Cancer

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

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