Recent advances and future prospects in topical creams from medicinal plants to expedite wound healing: a review

Gwarzo, Iliyasu Datti; Bohari, Siti Pauliena Mohd; Wahab, Roswanira Abdul; Zia, Arifullah

doi:10.1080/13102818.2022.2053340

Cited by 14 publications

(9 citation statements)

References 81 publications

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“…Medicinal herbs help wounds heal faster and with less pain, suffering, and scarring for the patient [ 63 ]. Wound healing could be achieved with medicinal plant ointment compositions [ 64 ]. This enhanced wound contraction by the crude extract ointments could be linked to plant extracts' ability to increase epithelial cell proliferation [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Ayele

Abebe

Muche

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Introduction. The solvent fractions of the fruits of Argemone mexicana L. (Papaveraceae) have not yet been explored scientifically for in vivo wound healing and anti-inflammatory activities. The objective of this study was, therefore, to evaluate in vivo wound healing and anti-inflammatory activities of the solvent fractions of the fruit of Argemone mexicana L. (Papaveraceae) in rats. Method. The crude extract of Argemone mexicana was fractionated with n-hexane, ethyl acetate, and distilled water. Wound healing activity was evaluated using excision and incision wound models while anti-inflammatory activity was evaluated using carrageenan-induced rat paw and cotton pellet-induced granuloma models. The fractions were evaluated at 5 and 10% ointments using moist-exposed burn ointment as the standard drug, and 100, 200, and 400 mg/kg test doses using aspirin, and dexamethasone as standard drugs for wound healing and anti-inflammatory activities, respectively. All treatment administrations were made orally for anti-inflammatory activity and applied topically for wound healing activity. Result. The 10% w/w ethyl acetate fraction ointment showed a significant percentage of wound contraction, reduced period of epithelialization, increased amount of fibrosis, neovascularization, and collagen tissue formation ( p < 0.01 ). The ethyl acetate fraction also showed a significant increase in tensile strength (55%; p < 0.01 ) and (81.10%; p < 0.01 ) at the tested doses of 5 and 10% w/w ointments, which was comparable to moist-exposed burn ointment. The ethyl acetate fraction also revealed a significant percent edema inhibition (61.41%; p < 0.01 ), suppression of the exudate (38.09% p < 0.01 ), and granuloma mass formations (53.47% p < 0.01 ) at the tested dose of 400 mg/kg. Conclusion. The results of this study showed that the Ethyl acetate fraction of Argemone mexicana fruit has significant wound healing and anti-inflammatory activities which support the traditional claims of the experimental plant.

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Section: Discussionmentioning

confidence: 99%

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Ayele

Abebe

Muche

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…These patterns are usually hidden but become recognizable during injury. TlRs and other receptors trigger inflammation when tissue damage occurs protecting tissue integrity and aiding in wound healing [ 249 ]. Gene expression regulation is a key factor in determining the quality of healing.…”

Section: Perspectivementioning

confidence: 99%

Electrospun nanofibers synthesized from polymers incorporated with bioactive compounds for wound healing

Palani,

Vijayakumar,

Monisha

et al. 2024

J Nanobiotechnol

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The development of innovative wound dressing materials is crucial for effective wound care. It’s an active area of research driven by a better understanding of chronic wound pathogenesis. Addressing wound care properly is a clinical challenge, but there is a growing demand for advancements in this field. The synergy of medicinal plants and nanotechnology offers a promising approach to expedite the healing process for both acute and chronic wounds by facilitating the appropriate progression through various healing phases. Metal nanoparticles play an increasingly pivotal role in promoting efficient wound healing and preventing secondary bacterial infections. Their small size and high surface area facilitate enhanced biological interaction and penetration at the wound site. Specifically designed for topical drug delivery, these nanoparticles enable the sustained release of therapeutic molecules, such as growth factors and antibiotics. This targeted approach ensures optimal cell-to-cell interactions, proliferation, and vascularization, fostering effective and controlled wound healing. Nanoscale scaffolds have significant attention due to their attractive properties, including delivery capacity, high porosity and high surface area. They mimic the Extracellular matrix (ECM) and hence biocompatible. In response to the alarming rise of antibiotic-resistant, biohybrid nanofibrous wound dressings are gradually replacing conventional antibiotic delivery systems. This emerging class of wound dressings comprises biopolymeric nanofibers with inherent antibacterial properties, nature-derived compounds, and biofunctional agents. Nanotechnology, diminutive nanomaterials, nanoscaffolds, nanofibers, and biomaterials are harnessed for targeted drug delivery aimed at wound healing. This review article discusses the effects of nanofibrous scaffolds loaded with nanoparticles on wound healing, including biological (in vivo and in vitro) and mechanical outcomes. Graphical Abstract

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“…Topical vehicle formulations such as creams and ointments have their places, but for chronic wounds, especially those that produce excessive exudate, hydrogels [ 22 ] may be the most beneficial hydrating vehicles due to their unique properties (see below). The correct combination of base components and bioactives (e.g., specific bioactives, mediators) allows for a wide range of topical vehicle formulations characterized by distinct physicochemical properties resulting in some advantages but also some specific drawbacks for wound healing [ 42 , 43 ], especially when applying creams [ 43 ] or ointments [ 42 ]. For example, occlusive ointments, which often have a fatty/hydrophobic base, are considered rather unfavorable in chronic wound treatment, and are primarily suitable for use on irritated, unwounded skin [ 42 ].…”

Section: The Importance Of Topical Vehicle Formulations For Autophagy...mentioning

confidence: 99%

“…They can protect against dehydration but tend to not contain water [ 42 ]. Meanwhile, the common ineffectiveness of cream formulations on exuding wounds has to do with the dilution of the cream in exude, thus altering the physicochemical properties and wound healing activity of the cream [ 43 ]. Furthermore, topical creams usually exhibit slow absorption rate and can only be used for a specific medication [ 43 ].…”

Section: The Importance Of Topical Vehicle Formulations For Autophagy...mentioning

confidence: 99%

Autophagy is the key to making chronic wounds acute in skin wound healing

Mijaljica¹,

Spada²,

Klionsky

et al. 2023

Autophagy

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As a highly regulated and dynamically balanced intracellular degradation mechanism, macroautophagy/autophagy plays an essential housekeeping role in different successive stages of skin wound healing; from the homeostasis and inflammatory stages to the proliferative and remodeling stages. Under both progressive and defective skin wound healing conditions, autophagy operates at different levels with a precise extent of activity, at the interface of inflammation, stress signaling and cell metabolism through a complex spatiotemporal cascade of molecular and cellular events. Depending on the wound healing conditions autophagic activity is fine-tuned and differentially modulated at each stage of skin wound healing in order to cope with stage-specific requirements. Here, we postulate that under favorable conditions autophagy may act as the key modulator of skin wound healing by making chronic wounds acute. Enhancing autophagy through the topical application of pro-autophagy biologics in an appropriate hydrating vehicle/moisturizing base such as hydrogels, onto a chronic skin wound may provide moisture and immune modulation, thus contributing to rapid and efficient skin wound healing. A moist environment is more conducive to skin wound healing as it helps to not only accelerate cell proliferation and migration, and extracellular matrix reorganization, but also promotes autophagy and reduces the incidence of inflammation. Abbreviation : AKT: AKT serine/threonine protein kinase; ECM: extracellular matrix; FN1: fibronectin 1; LAM: laminin; MMPs: matrix metallopeptidases; MMP2: matrix metallopeptidase 2; MRSA: methicillin-resistant Staphylococcus aureus ; MTOR: mechanistic target of rapamycin kinase; PI3K: phosphoinositide 3-kinase; TNF/TNF-α: tumor necrosis factor.

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Recent advances and future prospects in topical creams from medicinal plants to expedite wound healing: a review

Cited by 14 publications

References 81 publications

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Electrospun nanofibers synthesized from polymers incorporated with bioactive compounds for wound healing

Autophagy is the key to making chronic wounds acute in skin wound healing

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