Recent advances in 3-aminoindazoles as versatile synthons for the synthesis of nitrogen heterocycles

Abstract

The nitrogen-based heterocycles are the important class of structural scaffolds distributed in biologically active natural products, medical chemistry, and agrochemicals. Hence, there is an increasing interest in the development of...

Copper-catalyzed oxidative direct C3-cyanoarylation of quinoxalin-2(1H)-onesviadenitrogenative ring-opening of 3-aminoindazoles

“…3-Aminoindazoles are key intermediates in organic chemistry and the pharmaceutical industry. 16 3-Aminoindazoles as efficient arylating agents could form ortho -cyano aryl radicals via the cleavage of two C–N bonds. 17 The cyano group can be handily transformed into a diverse array of functional groups, which makes nitrile-derived compounds significant building blocks in synthetic chemistry.…”

Copper-catalyzed cross coupling reaction of sulfonyl hydrazides with 3-aminoindazoles

“… 1 Among them, 3-aminoindazoles, possessing a free amine group and an indazole skeleton, have emerged as versatile reagents widely applied in the construction of valuable nitrogen-containing heterocyclic compounds. 2 In general, the condensation annulation of 3-aminoindazoles with carbonyl compounds represented straightforward and efficient access to various polynitrogen heterocycles. 3 Many delightful achievements have also been made in radical-initiated denitrogenative reactions in the past several years, which represents one of the most significant achievements in synthetic chemistry ( Scheme 1a ).…”