Recent advances in antibacterial drugs

Rai, Jaswant; Randhawa, Gurpreet Kaur; Kaur, Mandeep

doi:10.4103/2229-516x.112229

Cited by 54 publications

(16 citation statements)

References 39 publications

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“…To sum up, antibiotic resistance will continue to rise rapidly during the next decades and new strategies will be needed to fight human pathogens such as L. monocytogenes [39,41]. In the present manuscript we have unveiled some potential new PrfA inhibitors that target the virulence of L. monocytogenes rather than the conventional regulatory pathways.…”

Section: Discussionmentioning

confidence: 90%

“…To circumvent this threat novel antibiotic analogs are being designed, new antibiotic combinations are being considered, promising bioenhancers are being explored and novel nanomaterials and nanoparticles are also being considered [38][39][40][41]. Unfortunately, it does not seem that in the short term these strategies alone will alleviate the current situation.…”

Section: Discussionmentioning

confidence: 99%

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In SilicoIdentification of Novel PrfA Inhibitors to Fight Listeriosis: A Virtual Screening and Molecular Dynamics Studies

Nizami

Tan

Arias-Moreno

2020

Preprint

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Listeria monocytogenes is considered to be one of the most dangerous foodborne pathogens as it can cause listeriosis, a life-threatening human disease. While the incidence of listeriosis is very low its fatality rate is exceptionally high. Because many multi-resistance Listeria monocytogenes strains that do not respond to conventional antibiotic therapy have been recently described, development of new antimicrobials to fight listeriosis is necessary. The positive regulatory factor A (PrfA) is a key homodimeric transcription factor that modulates the transcription of multiple virulence factors which are ultimately responsible of Listeria monocytogenes' pathogenicity. In the present manuscript we describe several new potential PrfA inhibitors that were identified after performing ligand-based virtual screening followed by structure-based virtual screening against the wild-type PrfA structure. The three top-scored drug-likeness inhibitors bound to the wild-type PrfA structure were further assessed by Molecular Dynamics simulations. Besides, the three top-scored inhibitors were docked into a constitutive active apoPrfA mutant structure and the corresponding complexes were also simulated. According to the obtained data, PUBChem 87534955 (P875) and PUBChem 58473762 (P584) may not only bind and inhibit wild-type PrfA but the aforementioned apoPrfA mutant as well. Therefore, P875 and P584 might represent good starting points for the development of a completely new set of antimicrobial agents to treat listeriosis.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

In SilicoIdentification of Novel PrfA Inhibitors to Fight Listeriosis: A Virtual Screening and Molecular Dynamics Studies

Nizami

Tan

Arias-Moreno

2020

Preprint

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“…Phosphors are widely utilized as a light source in our daily life for long time. [1][2][3][4][5][6][7][8][9] Phosphors are composed of two parts: a host crystal and an activator. Specific properties of both components as well as their interactions critically determine the emission efficiency of a particular phosphor.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Europium‐exchanged Titanate Nanoporous Phosphors

Chang

2015

J Chinese Chemical Soc

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Eu x (NH 4 ) 2-2x Ti 3 O 7 nanoporous phosphor was prepared by ion exchange method. (NH 4 ) 2 Ti 3 O 7 nanotubes were employed as the host structure by treating H 2 Ti 3 O 7 with NH 4 OH solution and the activator, Eu 2+ , was introduced into the host via ion exchange. This is an easy and feasible way to prepare a phosphor. The synthesized samples were characterized using TEM, XRD, N 2 adsorption-desorption isotherm, TPR, and fluorescence spectrophotometer. Experimental results showed that a portion of Eu 2+ ions was oxidized into Eu 3+ ions during ion exchange, resulting in the present phosphor with blue-emitting and red-emitting. Moreover, the tubular structure of Eu x (NH 4 ) 2-2x Ti 3 O 7 was distorted as Eu 2+ was placed into the host structure. This distortion is attributed to the electrostatic interaction between Eu 2+ and the electric field of the host structure.

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“…However, to make these agents easily understandable, Table 4 lists some recent antibacterial agents with their structure, class, and so on [22]. …”

Section: Recent Antimicrobial Agentsmentioning

confidence: 99%

Classification of Anti‐Bacterial Agents and Their Functions

Ullah¹,

Ali²

2017

Antibacterial Agents

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Bacteria that cause bacterial infections and disease are called pathogenic bacteria. They cause diseases and infections when they get into the body and begin to reproduce and crowd out healthy bacteria or to grow into tissues that are normally sterile. To cure infectious diseases, researchers discovered antibacterial agents, which are considered to be the most promising chemotherapeutic agents. Keeping in mind the resistance phenomenon developing against antibacterial agents, new drugs are frequently entering into the market along with the existing drugs. In this chapter, we discussed a revised classification and function of the antibacterial agent based on a literature survey. The antibacterial agents can be classified into five major groups, i.e. type of action, source, spectrum of activity, chemical structure, and function.

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Recent advances in antibacterial drugs

Cited by 54 publications

References 39 publications

In SilicoIdentification of Novel PrfA Inhibitors to Fight Listeriosis: A Virtual Screening and Molecular Dynamics Studies

In SilicoIdentification of Novel PrfA Inhibitors to Fight Listeriosis: A Virtual Screening and Molecular Dynamics Studies

Synthesis and Characterization of Europium‐exchanged Titanate Nanoporous Phosphors

Classification of Anti‐Bacterial Agents and Their Functions

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