Recent Advances in Antimicrobial Coatings and Material Modification Strategies for Preventing Urinary Catheter-Associated Complications

Kanti, S. P. Yamini; Csóka, Ildikó; Jójárt-Laczkovich, Orsolya; Adalbert, Lívia

doi:10.3390/biomedicines10102580

Cited by 16 publications

(12 citation statements)

References 127 publications

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“…The use of hydrogels, polytetrafluoroethylene (PTFE), polyethylene glycol (PEG), polyzwitterions, and specific enzymes as coatings all involve material modifications. As antimicrobial coatings, apart from various antibiotics (chosen for specific infecting agents), metallic ions, nanoparticles, nitric oxide bacteriophages, and antimicrobial peptides (AMPs) may be used in order to prevent biofilm formation [ 36 ]. Although there are numerous data from in vivo, in vitro, and clinical studies, a unanimous conclusion on which coating is the right choice for a specific pathogen has not been reached.…”

Section: Discussionmentioning

confidence: 99%

Purple Urine Bag Syndrome in a Home-Dwelling Elderly Female with Lumbar Compression Fracture: A Case Report

et al. 2023

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Purple urine bag syndrome (PUBS) is an uncommon, but usually benign, underrecognized clinical condition with the distressing presentation of purple, blue or reddish discoloration of a patient’s catheter bag and tubing in the setting of catheter-associated urinary tract infections (UTIs). PUBS is the result of the complex metabolic pathway of the dietary essential amino acid tryptophan. Its urinary metabolite, indoxyl sulfate, is converted into red and blue byproducts (indirubin and indigo) in the presence of the bacterial enzymes indoxyl sulfatase and phosphatase. The typical predisposing factors are numerous and include the following: female gender, advanced age, long-term catheterization and immobilization, constipation, institutionalization, dementia, increased dietary intake of tryptophan, chronic kidney disease, alkaline urine, and spinal cord injury (SCI). Here, we present a case of PUBS in a home-dwelling elderly female patient with a history of long-term immobility after a pathological spinal fracture, long-term catheterization, constipation, and malignant disease in remission. Urine culture was positive for Proteus mirabilis. This state can be alarming to both patients and physicians, even if the patient is asymptomatic. Healthcare professionals and caregivers need to be aware of this unusual syndrome as an indicator of bacteriuria in order to initiate proper diagnostics and treatment.

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Section: Discussionmentioning

confidence: 99%

Purple Urine Bag Syndrome in a Home-Dwelling Elderly Female with Lumbar Compression Fracture: A Case Report

et al. 2023

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“…Noteworthy data were obtained in similar studies in which silicone and latex catheters were evaluated against P. mirabilis . Zwitterions can either repel or prevent pathogen colonization, biofilm formation, and encrustation ( Kanti et al., 2022 ).…”

Section: Anti-fouling Approachesmentioning

confidence: 99%

“…It reduces reactive intermediates by releasing nitric oxide (NO), which interferes with ribosomes, DNA, and the cell wall to inhibit bacterial replication, growth, and biofilm formation ( Siddiq and Darouiche, 2012 ; Thompson et al., 2016 ). Nitrofurazone-coated catheters were tested against a wide spectrum of bacterial pathogens and were found to inhibit the adherence of E. coli and E. faecalis for 3–5 days( Stensballe, 2007 ; Desai et al., 2010 ; Kanti et al., 2022 ). In addition, several other comparative studies showed that the nitrofurazone-impregnated silicone catheter reduced the viable count of E. faecalis and inhibited S. epidermidis and P. aeruginosa biofilms ( Table 3 ) ( Kart et al., 2017 ; Al-Qahtani et al., 2019 ).…”

Section: Antimicrobial Coatings and Impregnationmentioning

confidence: 99%

Emerging evidence-based innovative approaches to control catheter-associated urinary tract infection: a review

Rajaramon

Shanmugam

Dandela

et al. 2023

Front. Cell. Infect. Microbiol.

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Healthcare settings have dramatically advanced the latest medical devices, such as urinary catheters (UC) for infection, prevention, and control (IPC). The continuous or intermittent flow of a warm and conducive (urine) medium in the medical device, the urinary catheter, promotes the formation of biofilms and encrustations, thereby leading to the incidence of CAUTI. Additionally, the absence of an innate immune host response in and around the lumen of the catheter reduces microbial phagocytosis and drug action. Hence, the review comprehensively overviews the challenges posed by CAUTI and associated risks in patients’ morbidity and mortality. Also, detailed, up-to-date information on the various strategies that blended/tailored the surface properties of UC to have anti-fouling, biocidal, and anti-adhesive properties to provide an outlook on how they can be better managed with futuristic solutions.

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“…Kidney stones are hard crystalline mineralized material that varies in size and is formed in the kidney or urinary tract. The complex phenotype of kidney stone disease is caused by the interplay of several genes, in conjunction with dietary and environmental variables [7]. Another urinary problem, a cyst, is a fluid-filled sac in the kidneys [8], whereas tumors are abnormal growths with symptoms such as abdominal pain, blood in the urine, and unexplained weight loss [9].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Capabilities of a Lightweight CNN Model in Accurately Identifying Renal Abnormalities: Cysts, Stones, and Tumors, Using LIME and SHAP

et al. 2023

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Kidney abnormality is one of the major concerns in modern society, and it affects millions of people around the world. To diagnose different abnormalities in human kidneys, a narrow-beam x-ray imaging procedure, computed tomography, is used, which creates cross-sectional slices of the kidneys. Several deep-learning models have been successfully applied to computer tomography images for classification and segmentation purposes. However, it has been difficult for clinicians to interpret the model’s specific decisions and, thus, creating a “black box” system. Additionally, it has been difficult to integrate complex deep-learning models for internet-of-medical-things devices due to demanding training parameters and memory-resource cost. To overcome these issues, this study proposed (1) a lightweight customized convolutional neural network to detect kidney cysts, stones, and tumors and (2) understandable AI Shapely values based on the Shapley additive explanation and predictive results based on the local interpretable model-agnostic explanations to illustrate the deep-learning model. The proposed CNN model performed better than other state-of-the-art methods and obtained an accuracy of 99.52 ± 0.84% for K = 10-fold of stratified sampling. With improved results and better interpretive power, the proposed work provides clinicians with conclusive and understandable results.

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Recent Advances in Antimicrobial Coatings and Material Modification Strategies for Preventing Urinary Catheter-Associated Complications

Cited by 16 publications

References 127 publications

Purple Urine Bag Syndrome in a Home-Dwelling Elderly Female with Lumbar Compression Fracture: A Case Report

Purple Urine Bag Syndrome in a Home-Dwelling Elderly Female with Lumbar Compression Fracture: A Case Report

Emerging evidence-based innovative approaches to control catheter-associated urinary tract infection: a review

Exploring the Capabilities of a Lightweight CNN Model in Accurately Identifying Renal Abnormalities: Cysts, Stones, and Tumors, Using LIME and SHAP

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