Recent advances in biological detection with magnetic nanoparticles as a useful tool

Lu, Liwei; Wang, Xiuyu; Xiong, Chuanxi; Yao, Li

doi:10.1007/s11426-015-5370-5

Cited by 37 publications

(15 citation statements)

References 124 publications

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“…[5][6][7][8][9][10] They are regarded as potential alternatives to natural enzymes, and have already been widely applied in numerous fields, such as biosensors, immunoassays, cancer therapy, pharmaceutical processes, pollutant removal, and the food industry etc. [11][12][13][14] These findings illustrated the great importance and commercial interests of exploring the use of nanomaterials as enzyme mimetics.…”

Section: Introductionmentioning

confidence: 99%

Ceria Nanoparticles as Enzyme Mimetics

Wang

Zhang

et al. 2017

Chin. J. Chem.

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In the past decades, enzyme mimetics based on ceria nanoparticles (nanoceria) have been developed as potential substitutes for nature enzymes. The mixed valence states of cerium and the patterns of oxygen vacancies on crystal planes result in different enzyme mimetic activities. In this review we survey the bio-applications of nanoceria-based enzyme mimetics as well as the underlying mechanisms. Factors influencing the enzyme mimetic activities and future perspective of nanoceria-based enzyme mimetics are also addressed.

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Section: Introductionmentioning

confidence: 99%

Ceria Nanoparticles as Enzyme Mimetics

Wang

Zhang

et al. 2017

Chin. J. Chem.

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“…They are characterized as a potential alternative to natural enzymes and are widely used in many industries such as immunoassay, biosensorica, pharmaceutical processes, oncotherapy, the food industry, ecology, etc. (Chen et al, , 2014Fu, 2014;Lu et al, 2015;Li & Zhang, 2016). This demonstrates the great importance and commercial interest of using nanomaterials as enzyme mimetics.…”

Section: Use Of Nanoparticlesmentioning

confidence: 89%

Enzyme-like activity of nanomaterials

Tsekhmistrenko

Bityutskyy

Цехмістренко

et al. 2018

Regul. Mech. Biosyst.

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In modern conditions, nanomaterials, especially nanoparticles of metals and nonmetals, are increasingly used in various industries. Due to their unique properties, in particular, the ability of nanoparticles to exhibit an enzyme-like effect they are widely used in biology, medicine, biotechnology, the food industry and agriculture. Important advantages of nanoparticles are their size, which enables specific properties to be present: their large surface area, the ability to transfer molecules and the ability to protect them from degradation and release over a long time, the location of action and the specificity of interaction with biological structures. Nanoparticles play a special role in the processes of neutralizing the active forms of oxygen. It has been established that a number of nanoparticles, in particular, Fe, Mn, Zn, Ce, Si and Se oxides, have an enzyme-like activity mimicking that of some enzymes. By changing the degree of oxidation, these particles can regenerate and continuously catalyze the reaction of neutralizing superoxide anion radicals, thus fulfilling the function of SOD and being the first link in protecting tissues and cells from oxidative stress in physiological and pathological conditions. It is proved that nanoparticles Mn3O4, Fe3O4, Co3O4, CeO2, LaCoO3 and other elements can effectively dispose of hydrogen peroxide and other peroxides, showing catalase-like and peroxidase-like activity. Nanozymes are characterized that exhibit the activity of oxidases, peroxidases and phosphatase. The prospect of using mimetics for complex in vitro analyzes of high-sensitivity biomarker disease detection is shown. The possibility of effective multi-use of nanoparticles as antioxidants is indicated. There are good prospects for further research on properties and the use of polyfunctional particles that are easily synthesized, reliable and inexpensive. More work is needed to determine the interaction of enzymomimetics with biological molecules such as proteins, carbohydrates and lipids, and also to take into account the peculiarities of their metabolism, clearance, degradation, biocompatibility and side effects, since individual nanoparticles have the potential to be deposited in separate organs.

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“…Numerous catalytically active nanomaterials of various origin are currently being created in the world (Cormode et al, 2018;Titus et al, 2019), which include nanomaterials with enzyme-mimetic properties, as a potential alternative to natural enzymes and for use in immunoassay, biosensor, oncotherapy, pharmacy, food industry, ecology, etc. (Chen et al, 2012(Chen et al, , 2014Fu, 2014;Lu et al, 2015;Li & Zhang, 2016;Tsekhmistrenko et al, 2018;Mu et al, 2019). Nanomaterial-based mimetics, compared to naturally occurring enzymes, have stability under harsh conditions, are capable of altering catalytic activity, and their production is relatively uncomplicated and economically justified, making them of great importance in practical applications (Wei & Wang, 2013;Lin et al, 2014).…”

Section: Characterization Of Nanoparticlesmentioning

confidence: 99%

Bacterial synthesis of nanoparticles: A green approach

et al. 2020

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In recent decades, the attention of scientists has been drawn towards nanoparticles (NPs) of metals and metalloids. Traditional methods for the manufacturing of NPs are now being extensively studied. However, disadvantages such as the use of toxic agents and high energy consumption associated with chemical and physical processes impede their continued use in various fields. In this article, we analyse the relevance of the use of living systems and their components for the development of "green" synthesis of nano-objects with exceptional properties and a wide range of applications. The use of nano-biotechnological methods for the synthesis of nanoparticles has the potential of large-scale application and high commercial potential. Bacteria are an extremely convenient target for green nanoparticle synthesis due to their variety and ability to adapt to different environmental conditions. Synthesis of nanoparticles by microorganisms can occur both intracellularly and extracellularly. It is known that individual bacteria are able to bind and concentrate dissolved metal ions and metalloids, thereby detoxifying their environment. There are various bacteria cellular components such as enzymes, proteins, peptides, pigments, which are involved in the formation of nanoparticles. Bio-intensive manufacturing of NPs is environmentally friendly and inexpensive and requires low energy consumption. Some biosynthetic NPs are used as heterogeneous catalysts for environmental restoration, exhibiting higher catalytic efficiency due to their stability and increased biocompatibility. Bacteria used as nanofactories can provide a new approach to the removal of metal or metalloid ions and the production of materials with unique properties. Although a wide range of NPs have been biosynthetic and their synthetic mechanisms have been proposed, some of these mechanisms are not known in detail. This review focuses on the synthesis and catalytic applications of NPs obtained using bacteria. Known mechanisms of bioreduction and prospects for the development of NPs for catalytic applications are discussed.

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Recent advances in biological detection with magnetic nanoparticles as a useful tool

Cited by 37 publications

References 124 publications

Ceria Nanoparticles as Enzyme Mimetics

Ceria Nanoparticles as Enzyme Mimetics

Enzyme-like activity of nanomaterials

Bacterial synthesis of nanoparticles: A green approach

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