2024
DOI: 10.1097/cm9.0000000000003031
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Recent advances in cancer-associated fibroblast: Biomarkers, signaling pathways, and therapeutic opportunities

Donger Zhou,
Lei Zheng

Abstract: Anti-cancer therapies usually focus on tumor cells, but non-tumor stromal components in the tumor microenvironment also play vital roles in tumor initiation and progression, which may be the prognostic factors and potential therapeutic targets. Cancer-associated fibroblasts (CAFs) are the essential component in the tumor environment, exhibiting high heterogeneity in their cell origin and phenotype with diverse functions that influence tumor angiogenesis, immune systems, and metabolism. Single-cell RNA sequenci… Show more

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