Recent advances in cell membrane camouflage-based biosensing application

Yu, Xiaomeng; Sha, Lingjun; Liu, Qi; Zhao, Yingyan; Fang, Huan; Cao, Ya; Zhao, Jing

doi:10.1016/j.bios.2021.113623

Cited by 34 publications

(25 citation statements)

References 90 publications

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“…Studies have shown that exosomes could specifically target receptor cells to deliver their cargoes [ 44 – 46 ]. The homologous targeting of cancer cell membranes has been widely applied in tumor therapy, but the tumor-targeting mechanism is still unclear need to be further elucidated [ 47 ]. In our study, the nanoparticles were shown to be stable in structure and have excellent antitumor effects and no obvious side effects.…”

Section: Discussionmentioning

confidence: 99%

Minimizing adverse effects of Cerenkov radiation induced photodynamic therapy with transformable photosensitizer-loaded nanovesicles

et al. 2022

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Background Photodynamic therapy (PDT) is a promising antitumor strategy with fewer adverse effects and higher selectivity than conventional therapies. Recently, a series of reports have suggested that PDT induced by Cerenkov radiation (CR) (CR-PDT) has deeper tissue penetration than traditional PDT; however, the strategy of coupling radionuclides with photosensitizers may cause severe side effects. Methods We designed tumor-targeting nanoparticles (131I-EM@ALA) by loading 5-aminolevulinic acid (ALA) into an 131I-labeled exosome mimetic (EM) to achieve combined antitumor therapy. In addition to playing a radiotherapeutic role, 131I served as an internal light source for the Cerenkov radiation (CR). Results The drug-loaded nanoparticles effectively targeted tumors as confirmed by confocal imaging, flow cytometry, and small animal fluorescence imaging. In vitro and in vivo experiments demonstrated that 131I-EM@ALA produced a promising antitumor effect through the synergy of radiotherapy and CR-PDT. The nanoparticles killed tumor cells by inducing DNA damage and activating the lysosome-mitochondrial pathways. No obvious abnormalities in the hematology analyses, blood biochemistry, or histological examinations were observed during the treatment. Conclusions We successfully engineered a nanocarrier coloaded with the radionuclide 131I and a photosensitizer precursor for combined radiotherapy and PDT for the treatment of breast cancer. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Minimizing adverse effects of Cerenkov radiation induced photodynamic therapy with transformable photosensitizer-loaded nanovesicles

et al. 2022

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“…Third, parts of biological membranes can induce an immune response or contain an anti-tumor substance, and so contribute to inhibiting the growth of tumor, directly. 90–100,200–210…”

Section: Discussionmentioning

confidence: 99%

“…The membrane-camouflaged nanoparticles platform, which combines the unique function of cell membranes with the versatility of synthetic nanomaterials, has emerged as a novel drug delivery strategy, and is expected to improve the efficacy of treatments for a variety of diseases. [86][87][88][89][90][91] In this section, we focus on some related applications of nanomaterials based on natural cell membranes, tumor cell membranes or bacterial membranes in cancer therapy.…”

Section: Minqian Zhumentioning

confidence: 99%

“…Third, parts of biological membranes can induce an immune response or contain an anti-tumor substance, and so contribute to inhibiting the growth of tumor, directly. [90][91][92][93][94][95][96][97][98][99][100][200][201][202][203][204][205][206][207][208][209][210] Although biological membranes have been widely used in tumor treatments, the problems of the biological bionic platform cannot be ignored. First, we should consider how to make the extraction process of biological membranes simpler.…”

Section: Biomaterials Science Reviewmentioning

confidence: 99%

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Recent advances in biological membrane-based nanomaterials for cancer therapy

Shen

Zhu

et al. 2022

Biomater. Sci.

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“…Therefore, it is of great interest for us to couple the high catalytic selectivity of living cells with the high activity of nano-metal catalysts, exploring the selectivity of the living cell catalytic systems, including the intracellular enzyme-like metal nanocatalysts with high activity, 23,24 and the cell membrane with high selectivity. 10,25 The LCCSs not only have high selectivity, self-replication and recyclability but also have high activity and stability due to the dispersing and stabilizing effects of intracellular proteins, 26 which might open unforeseen opportunities to achieve the multitudinous special catalytic processes that do not occur in natural catalytic systems for desirable chemical applications.…”

Section: Introductionmentioning

confidence: 99%