Recent advances in coherent detection imaging (CDI) in biomedicine: laser tomography of human tissues in vivo and in vitro

Devaraj, B.; Usa, Masashi; Chan, Kin Pui; Akatsuka, Takao; Inaba, Humio

doi:10.1109/2944.577330

Cited by 46 publications

(19 citation statements)

References 32 publications

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“…Many historically successful techniques have been ba− sed on transmitted radiation to ascertain that complete vol− ume is sampled [16][17][18]. This is in contrast with the highly acclaimed optical tomography that uses Michelson inter− ferometric setup to evaluate the material in depth, in reflec− tion, and upon a double−pass under optimal conditions of perfect alignment [19].…”

Section: Introductionmentioning

confidence: 94%

Tissue characterization with ballistic photons: counting scattering and/or absorption centres

Corral-Martínez

Strojnik

Паез

2015

Opto-Electronics Review

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We describe a new method to separate ballistic from the scattered photons for optical tissue characterization. It is based on the hypothesis that the scattered photons acquire a phase delay. The photons passing through the sample without scattering or absorption preserve their coherence so they may participate in interference. We implement a Mach−Zehnder experimental setup where the ballistic photons pass through the sample with the delay caused uniquely by the sample indices of refraction. We incorporate a movable mirror on the piezoelectric actuator in the sample arm to detect the amplitude of the modulation term. We present the theory that predicts the path−integrated (or total) concentration of the scattering and absorption centres. The proposed technique may characterize samples with transmission attenuation of ballistic photons by a factor of 10

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Section: Introductionmentioning

confidence: 94%

Tissue characterization with ballistic photons: counting scattering and/or absorption centres

Corral-Martínez

Strojnik

Паез

2015

Opto-Electronics Review

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“…The authors have engaged in development of small, high-performance all-solid-state wavelength-tunable lasers with long life as optical sources for medical applications and for medical environments [1]. Specifically, the authors group has been developing transmission-type optical CT equipment that uses CDI (coherent detection imaging) based on optical heterodyne detection [2]. As an optical source for such an application, a coherent source of a stable single-longitudi-nal-mode continuous wave (CW) output is needed in addition to wavelength tunability [3].…”

Section: Introductionmentioning

confidence: 99%

> 6-W continuous-wave, efficient, low-noise, diode-pumped intracavity-doubled Nd:YAG laser for pumping Ti: Sapphire lasers

Tsunekane

Taguchi

Inaba

1998

Electron. Comm. Jpn. Pt. II

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“…Extraction ofthe ballistic photons from the diffuse background can yield images with decreased noise and increased contrast. There are many methods by which least scattered photons can be discriminated from a multiply scattered background, including time-and frequencydomain techniques (3,4), transillumination laser computed tomography (5), and confocal detection (6). Polarimetry, in which the polarization state of light incident on a sample is compared with the polarization state of light exiting the sample, has recently been under much study as another method ofdiscrimination (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

<title>Polarized light propagation in turbid media</title>

Sankaran¹,

Maitland

Walsh³

1999

SPIE Proceedings

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Polarimetry, which is a comparison ofthe polarization state oflight before andafter it has interacted with a material, can be used to discriminate unscattered and weakly scattered photons from multiply scattered photons. Weakly scattered photons tend to retain their incident polarization state whereas highly scattered photons become depolarized; thus, polarization-based discrimination techniques can be used to image through tissue with decreased noise and increased contrast. Many previous studies investigating polarization-based discrimination have been conducted on tissue phantoms, with the ultimate goal being noninvasive imaging of breast tumors. We demonstrate here that linearly and circularly polarized light propagate differently in common tissue phantoms than in two different tissue types. Measurements of the degree of linear and circular polarization were conducted using two independent techniques on tissue phantoms consisting of polystyrene and Intralipid microsphere suspensions, and on porcine adipose tissue and porcine myocardium. We show that contraiy to expectations made from studies in the phantoms, linearly polarized light survives through more scattering events than circularly polarized light in both adipose tissue, which contains quasi-spherical scatterers, and myocardium, which contains quasi-spherical and cylindrical scatterers. Differences between spherical and biological scatterers are discussed, along with the impact of tissue birefringence on degree ofpolarization measurements.

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Recent advances in coherent detection imaging (CDI) in biomedicine: laser tomography of human tissues in vivo and in vitro

Cited by 46 publications

References 32 publications

Tissue characterization with ballistic photons: counting scattering and/or absorption centres

Tissue characterization with ballistic photons: counting scattering and/or absorption centres

> 6-W continuous-wave, efficient, low-noise, diode-pumped intracavity-doubled Nd:YAG laser for pumping Ti: Sapphire lasers

<title>Polarized light propagation in turbid media</title>

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