“…7,8 While this substitution reaction has been widely studied to determine the scope and mechanism, new substrates or nucleophiles usually require a new ligand screen to nd the optimal catalyst. 4,6,9,10,11 The selectivity in this reaction depends on a complex interplay between steric interactions favoring a certain allyl geometry, dynamic interconversion through exo-endo isomerization of the allyl moiety, and electronic effects whereby the ligand can in uence the regioselectivity of nucleophilic attack. 6,12 The catalytic cycle of this reaction proceeds 6,[13][14][15] through an oxidative addition to form the reactive h 3allyl palladium intermediate, which has been studied by X-ray crystallography.…”