Sheets of aluminum 2017A-T451 and 7075-T651 were friction stir-welded in a butt-weld configuration. An existing computational model of the welding process for temperature distribution and material flow was adapted to estimate the phase transformations that occur across the weld zone. Near the weld center, process temperatures are sufficient to fully dissolve the equilibrium η phase in 7075 and partially dissolve the equilibrium S phase in 2017A. Upon cooling, Guinier-Preston (GP) and Guinier-Preston-Bagaryatsky (GPB) zones re-precipitate, and hardness recovers. Due to the more complete dissolution of the equilibrium phase in 7075, the hardness recovery skews toward whichever side of the weld, i.e., the advancing or retreating side, represents the 7075 workpiece. Phase transformation maps generated by the numerical simulation align not only with the hardness profiles taken across the weld zone, but also with positron lifetimes obtained through positron annihilation lifetime spectroscopy (PALS). Boundaries between the aluminum matrix and the secondary phases provide open volumes to trap positrons; therefore, positron lifetimes across the weld correspond with the phase transformations that occur in 7075 and 2017A during processing.