Irreversible organ damage or even death frequently occurs when humans or animals unconsciously drink contaminated water. Therefore, in many countries drinking water is disinfected to ensure harmful pathogens are removed from drinking water. If upstream water treatment prior to disinfection is not adequate, disinfection by-products (DBPs) can be formed. DBPs can exist as wide variety of compounds, but up till now, only several typical compounds have drinking water standards attributed to them. However, it is apparent that the range of DBPs present in water can comprise of hundreds of compounds, some of which are at high enough concentrations that can be toxic or potentially carcinogenic. Hence, it becomes increasingly significant and urgent to develop an accessible, affordable and durable sensing platform for a broader range and more sensitive detection of DBPs. Compared with well-established laboratory detection techniques, electrochemical sensing has been identified as a promising alternative that will provide rapid, affordable and sensitive DBPs monitoring in remote water sources. Therefore, this article provides a review on current state-of-the-art development (within last decade) in electrochemical sensing to detect organic DBPs in water, which covered three major aspects: (1) recognition mechanism, (2) electrodes with signal amplification, and (3) signal read-out techniques. Moreover, comprehensive quality assessments on electrochemical biosensors, including linear detection range, limit of detection (LoD) and recovery, have also been summarized.