Recent advances in iron oxide nanocrystal technology for medical imaging☆

Corot, Claire; Robert, Philippe; Idée, Jean‐Marc; Port, Marc

doi:10.1016/j.addr.2006.09.013

Cited by 1,372 publications

(1,173 citation statements)

References 205 publications

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“…The reported half-life of SPIO particles in the bloodstream ranges between 15 and 30 minutes (30), and it is reported to range between 2 and 3 hours in the ultra-small form (29). In the current study, the halflife of SPIO particles in the area of BBB opening was Ϸ7 days, a much longer time than that expected in the blood.…”

Section: Discussionmentioning

confidence: 61%

“…In this regard, micrometer-sized paramagnetic iron oxide (MPIO) particles containing a larger amount of iron within a unit volume may increase the sensitivity to deposition of single particles in the brain (31). In addition, ultra-small superparamagnetic iron oxide (USPIO) can leak into smaller pore and may improve the detectability of BBB opening following brain sonication (29).…”

Section: Discussionmentioning

confidence: 99%

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Magnetic resonance imaging enhanced by superparamagnetic iron oxide particles: Usefulness for distinguishing between focused ultrasound‐induced blood–brain barrier disruption and brain hemorrhage

Liu

Hsu

Chu

et al. 2008

Magnetic Resonance Imaging

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Purpose:To investigate the usefulness of a fully flow-compensated heavy T2*-weighted imaging enhanced by superparamagnetic iron oxide (SPIO) particles for distinguishing between focused ultrasound-induced disruption of bloodbrain barrier (BBB) and brain hemorrhage. Materials and Methods:Focused ultrasound (frequency: 1.5 MHz) was used to induce disruption of the BBB in 39 rats. Two T2*-weighted images were obtained before and after SPIO administration. Preenhanced T2*-weighted images were used to detect hemorrhage. Detection of BBB disruption was performed on SPIO-enhanced images. Thirty-four rats were sacrificed after magnetic resonance (MR) scanning for histological confirmation of brain lesions. Theremaining five animals were followed up for 35 days.Prussian blue staining was performed on histological sections to detect SPIO particles in the brain. Results:After SPIO injection the areas of BBB disruption in rat brain were significantly enlarged. The area of mismatch between the T2*-weighted images indicated a safe region where BBB opening occurred without hemorrhagic complications. In the longitudinal study, removal of SPIO occurred at a faster rate in hemorrhagic areas, albeit being closer to that occurring in the liver. The presence of SPIO was confirmed by Prussian blue staining in brain parenchyma and capillary endothelial cells in areas of BBB disruption.Conclusion: T2*-weighted images-either with and without SPIO enhancement-may differentiate focused ultrasound-induced BBB disruption from brain hemorrhage.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging enhanced by superparamagnetic iron oxide particles: Usefulness for distinguishing between focused ultrasound‐induced blood–brain barrier disruption and brain hemorrhage

Liu

Hsu

Chu

et al. 2008

Magnetic Resonance Imaging

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“…Yet, MNPs have shown better capability to reduce the T 2 signal intensity and are more used for providing negative contrast. [739] Among the promising MNPs, the next generation was (ultrasmall) superparamagnetic iron oxide (SPIOs and USPIOs) nanoparticles that have been developed for both [740] Ferucarbotran, ferumoxtran-10, fetumoxytol (Feraheme), ferumoxides, ferristeneand, and ferumoxsil are of some contrast agents at current clinical trials. [733] Feridex and Resovist are approved by food and drug administration (FDA) for liver imaging.…”

Section: Mrimentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…[25] Their iron oxide core distorts the magnetic field, causing a rapid decreases in T1-and T2-relaxation times of water molecules, resulting in an increased signal intensity on T1-weighted images and a decrease of signal on T2-weighted-gradient echo images. [25,26] Areas of altered intensity on delayed MRI scans presumably reflect the infiltration of USPIO-loaded macrophages in active MS lesions.…”

Section: Ultrasmall Superparamagnetic Particles Of Iron Oxidementioning

confidence: 99%

Novel MRI and PET markers of neuroinflammation in multiple sclerosis

Hagens

Berckel

Barkhof

2016

Current Opinion in Neurology

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Purpose of reviewGadolinium-enhancement depicts BBB disruption associated with new inflammatory MRI lesions in MS and is widely used for diagnosis and therapeutic monitoring. However, earlier and more specific markers of inflammation are urgently needed.  TSPO PET shows that increased microglia activation is present in both normal appearing tissue and MS specific lesions and is related to disease severity and progression  A wide range of novel PET markers will give us unique insights in the pathophysiology of MS and the pharmacokinetics of drugs used in this disease. Recent findings

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Recent advances in iron oxide nanocrystal technology for medical imaging☆

Cited by 1,372 publications

References 205 publications

Magnetic resonance imaging enhanced by superparamagnetic iron oxide particles: Usefulness for distinguishing between focused ultrasound‐induced blood–brain barrier disruption and brain hemorrhage

Magnetic resonance imaging enhanced by superparamagnetic iron oxide particles: Usefulness for distinguishing between focused ultrasound‐induced blood–brain barrier disruption and brain hemorrhage

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Novel MRI and PET markers of neuroinflammation in multiple sclerosis

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