Recent Advances in Lipid-Based Drug Delivery

Nishida, Koyo

doi:10.3390/pharmaceutics13070926

Cited by 5 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nano-drug delivery carrier, as a nano-sized drug carrier system, can improve the safety of chemotherapy drugs used for antitumor and improve the therapeutic effect. 7,11 Common nano-drug carriers mainly include polymer nanocarriers, liposomes and inorganic nanocarriers (such as gold nanocarriers, silica nanocarriers and magnetic nanocarriers, etc. ) 12–15…”

Section: Introductionmentioning

confidence: 99%

“…Nano-drug delivery carrier, as a nanosized drug carrier system, can improve the safety of chemotherapy drugs used for antitumor and improve the therapeutic effect. 7,11 Common nano-drug carriers mainly include polymer nanocarriers, liposomes and inorganic nanocarriers (such as gold nanocarriers, silica nanocarriers and magnetic nanocarriers, etc.) [12][13][14][15] Compared with normal tissues, tumor tissues have abundant blood vessels, irregular blood vessel wall cells, and nanoparticles are easy to ooze from tumor blood vessels (Fig.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nanoparticle-based drug delivery systems targeting cancer cell surfaces

Hong

Wen

et al. 2023

RSC Adv.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanoparticle-based drug delivery systems targeting cancer cell surfaces

Hong

Wen

et al. 2023

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…The literature includes many studies regarding the fabrication of various drug delivery systems exhibiting magnetic properties [42][43][44]. Materials such as synthetic polyelectrolytes and natural polymers (polysaccharides, polypeptides and polynucleotides, lipids, and multivalent dyes) can be used as layer constituents to fabricate the shells [45][46][47]. By incorporating various particles such as magnetite, iron, nickel, and cobalt, the drug carriers are attracted to a magnetic field [48,49].…”

Section: Introductionmentioning

confidence: 99%

Transport of Magnetic Polyelectrolyte Capsules in Various Environments

Stavarache

Vînătoru²,

Mason

2022

Coatings

View full text Add to dashboard Cite

Microcapsules consisting of eleven layers of polyelectrolyte and one layer of iron oxide nanoparticles were fabricated. Two types of nanoparticles were inserted as one of the layers within the microcapsule’s walls: Fe2O3, ferric oxide, having a mean diameter (Ø) of 50 nm and superparamagnetic Fe3O4 having Ø 15 nm. The microcapsules were suspended in liquid environments at a concentration of 108 caps/mL. The suspensions were pumped through a tube over a permanent magnet, and the accumulation within a minute was more than 90% of the initial concentration. The design of the capsules, the amount of iron embedded in the microcapsule, and the viscosity of the transportation fluid had a rather small influence on the accumulation capacity. Magnetic microcapsules have broad applications from cancer treatment to molecular communication.

show abstract

“…β-hydroxybutyrate acts as a stress response molecule, regulating the antioxidant defense program to maintain redox homeostasis 21 . Development in the field of medicine with accelerated drug delivery systems to target organs can increase therapeutic efficacy 22 . In addition, therapies aimed at increasing the circulating ketones holds potential for improving endothelial dysfunction.…”

mentioning

confidence: 99%

The effects of Ketone Body β-hydroxybutyrate on eNOS Levels and VCAM-1 Expression in Wistar Rats Exposed to Cigarette Smoke

Andrianto,

Ardiana,

Wardhani

et al. 2024

RJPT

View full text Add to dashboard Cite

Background and Aim: Cigarette smoking is strongly associated with coronary artery disease and atherosclerosis, both of which are influenced by endothelial dysfunction. Antioxidant therapy has the potential to inhibit the pathogenesis of atherosclerosis. purpose of the study was to assess the antioxidant potential of β-hydroxybutyrate by examining its effects on eNOS levels and VCAM-1 expression in male Wistar rats exposed to cigarette smoke. Material and methods:. There were 25 Wistar rats involved in this study under a laboratory experiment, which were distributed into five experimental groups. Two control groups were included, with one group receiving no intervention (K-) and the other group exposed to daily exposure to 40 cigarette smoke (K+). The remaining three groups received daily doses of β-hydroxybutyrate-(R)-1,3-butanediol monoester supplement (DeltaG; KE) at 1.5g/kg/day (P1), 3g/kg/day (P2), and 6g/kg/day (P3), respectively, in addition to daily exposure to 40 cigarette smoke. After a 28-day exposure period, eNOS levels and VCAM-1 expression in the aortic tissue were measured. The data were analyzed using the ANOVA test, followed by Fisher’s LSD post hoc test. Results: The administration of β-hydroxybutyrate led to a significant increase in eNOS levels in the Wistar rat aorta (p = 0.036; p<0.05). However, there were no huge contrasts seen in VCAM-1 expression (p = 0.426; p>0.05). Conclusion: This study demonstrated that while Wistar rats exposed to cigarette smoke for 28 days experienced an increase in eNOS levels, there was no decrease in VCAM-1 expression.These findings suggest the potential of β-hydroxybutyrate as a vasodilator in mitigating the effects of cigarette-induced endothelial dysfunction.

show abstract

Recent Advances in Lipid-Based Drug Delivery

Abstract: Here, I report recent advances in lipid-based drug delivery systems, with a focus on their production, controlled drug release, targeting, and co-delivery [...]

Cited by 5 publications

References 10 publications

Nanoparticle-based drug delivery systems targeting cancer cell surfaces

Nanoparticle-based drug delivery systems targeting cancer cell surfaces

Transport of Magnetic Polyelectrolyte Capsules in Various Environments

The effects of Ketone Body β-hydroxybutyrate on eNOS Levels and VCAM-1 Expression in Wistar Rats Exposed to Cigarette Smoke

Contact Info

Product

Resources

About