Recent Advances in Molecular Diagnosis and Prognosis of Childhood B Cell Lineage Acute Lymphoblastic Leukemia (B-ALL)

Agarwal, Manisha; Seth, Rachna; Chatterjee, Tathagata

doi:10.1007/s12288-020-01295-8

Cited by 6 publications

(5 citation statements)

References 83 publications

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“…Most patients present a common immunophenotype and belong to the intermediate risk group. The frequency of genetic alterations is also within common ranges reported in European countries 19 . After preprocessing and filtering (see 'Methods' and Figure S1), 188 patients were retained for analysis.…”

Section: Patient Cohort Is Representative Of Childhood Bcp-all Popula...supporting

confidence: 75%

Computational flow cytometry immunophenotyping at diagnosis is unable to predict relapse in childhood B-cell Acute Lymphoblastic Leukemia

Martínez-Rubio,

Chulián,

Niño-López

et al. 2024

Preprint

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B-cell Acute Lymphoblastic Leukemia is the most prevalent form of childhood cancer, with approximately 15\% of patients undergoing relapse after initial treatment. Further advancements depend on novel therapies and more precise risk stratification criteria. In the context of computational flow cytometry and machine learning, this paper aims to explore the potential prognostic value of flow cytometry data at diagnosis, a relatively unexplored direction for relapse prediction in this disease. To this end, we collected a dataset of 252 patients from three hospitals and implemented a comprehensive pipeline for multicenter data integration, feature extraction, and patient classification, comparing the results with existing algorithms from the literature. The analysis revealed no significant differences in immunophenotypic patterns between relapse and non-relapse patients and suggests the need for alternative approaches to handle flow cytometry data in relapse prediction.

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Section: Patient Cohort Is Representative Of Childhood Bcp-all Popula...supporting

confidence: 75%

Computational flow cytometry immunophenotyping at diagnosis is unable to predict relapse in childhood B-cell Acute Lymphoblastic Leukemia

Martínez-Rubio,

Chulián,

Niño-López

et al. 2024

Preprint

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“…Deletions of the IKZF1 gene which result in haploinsufficiency constitute up to 55% of B-ALL with IKZF1 deletions. Focal exons 4-7 deletions affecting the DNA-binding domain compose of 33% of IKZF1 deletions, and exert a dominantnegative effect over the unaffected allele, resulting in loss of the tumor suppressor function attributed to wildtype IKZF1 (60). Exons 4-7 deletions lead to more severe phenotype than haploinsufficiency in B-ALL patients.…”

Section: Other Significant Gene Alterationsmentioning

confidence: 99%

“…Other genes, which have been reported to be deleted in B-ALL, include ABL1, CASP8AP2, CD200/BTLA, MLLT3, IKZF2, NF1, PHF6, PTEN, PTPN2, TBL1XR1, TP53, and VPREB1. Deletions in VPREB1, RB1, IKZF2, and TBL1XR1 can be biallelic (60).…”

Section: Other Significant Gene Alterationsmentioning

confidence: 99%

Prognostic and Predictive Biomarkers in Precursor B-cell Acute Lymphoblastic Leukemia

Zhang

Habeebu

2022

Leukemia

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Precursor B-cell acute lymphoblastic leukemia (B-ALL) is a hematologic malignancy characterized by clonal proliferation of abnormal B-cell precursors in the bone marrow. Most of the B-ALL cases are diagnosed in children, although it can present at any age. Thanks to the tremendous advances in our understanding of its biology, identification of more and more prognostic and predictive biomarkers, and application of individualized risk-adjusted treatment, B-ALL has become the most curable malignancy in children, with a long-term survival rate close to 90% in newly diagnosed Note to the Reader: This chapter is part of the book Leukemia (ISBN: 978-0-6453320-7-0), scheduled for publication in September 2022. The book is being published by Exon Publications,

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“…Las leucemias en los niños provienen a partir de las primitivas células B y T. que sufren cambios moleculares, aun en estado inmaduro. En los últimos años hubo importantes avances en el diagnóstico y tratamiento, basado en estudios ( 4) moleculares . Los cambios en las líneas, moleculares pueden ser secundarios a eventos prenatales o postnatales relacionados con factores genéticos y epigenéticos, con traslocaciones y mutaciones genéticas⁽⁵⁾.…”

Section: Introductionunclassified

Factores de riesgo ambientales y perinatales en pacientes pediátricos con Leucemia Linfoblástica aguda, de una población hospitalaria. Estudio de caso-control.

Martínez¹,

Talavera²,

Benítez³

et al. 2022

Pediatr (Asunción).

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Introducción: En la Leucemia linfoblástica aguda se han estudiado el rol de factores de riesgo ambientales y genéticos. Menos frecuentemente otros como los perinatales y parentales El objetivo del estudio fue analizar los factores de riesgo ambientales, parentales y perinatales de los niños con Leucemia linfoblástica aguda (LLA) en tratamiento en el servicio de oncología de un hospital pediátrico. Materiales y Métodos. estudio de caso-control, realizado en el departamento de oncohematología de un hospital pediátrico. Los casos fueron niños con diagnóstico de leucemia linfoblástica aguda y los controles niños con patología quirúrgica, previamente sanos pareados por edad. Se estudiaron variables ambientales, perinatales y parentales. Los análisis uni y multivariado fueron realizados en SPSS y los resultados se expresaron en OR con IC 95%. El protocolo fue aprobado por el comité de ética institucional. Resultados se incluyó 66 casos y 132 controles. El 33,3 (22/66) vs el 8,3% (11/132) OR 5,5 (IC 95% 2,4 – 12,5 p=0,0001 de los casos y controles respectivamente, eran residentes desde el nacimiento de los departamentos con mayor área de cultivos. En el análisis multivariado el riesgo de proceder de departamentos con extensas áreas de cultivo fue 3,6 veces mayor, OR 3,6 (IC 95% 1,4 -9) p=0,008 ajustado por la edad materna, antecedente de hospitalización neonatal, ocupación paterna y exposición a rayos X. Conclusiones La residencia en zonas con gran extensión de cultivos fue el factor de riesgo ambiental en los niños con LLA de una población hospitalaria. Palabras claves: Leucemia linfoblástica aguda, niños, factores de riesgo, contaminantes ambientales. Correspondencia: Mirta Mesquita Correo: mirtanmr@gmail.com Conflicto de interés: Las autoras declaran no tener conflicto de intereses. Fuente de financiamiento: El trabajo no recibió financiación externa. Recibido: 21/03/2022 Aceptado: 07/06/2022

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Recent Advances in Molecular Diagnosis and Prognosis of Childhood B Cell Lineage Acute Lymphoblastic Leukemia (B-ALL)

Cited by 6 publications

References 83 publications

Computational flow cytometry immunophenotyping at diagnosis is unable to predict relapse in childhood B-cell Acute Lymphoblastic Leukemia

Computational flow cytometry immunophenotyping at diagnosis is unable to predict relapse in childhood B-cell Acute Lymphoblastic Leukemia

Prognostic and Predictive Biomarkers in Precursor B-cell Acute Lymphoblastic Leukemia

Factores de riesgo ambientales y perinatales en pacientes pediátricos con Leucemia Linfoblástica aguda, de una población hospitalaria. Estudio de caso-control.

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