Recent advances in molecular recognition in water: artificial receptors and supramolecular catalysis

A one-pot three-component reaction involving 2-aminochromone in aqueous micellar medium: a green synthesis of hexahydrochromeno[2,3- $$b$$ b ]quinolinedione

“…Surprisingly, using 1.0 M aqueous TBAB as the reaction medium produced 7a in 50 % yield (entry 8). Upon increasing the concentration of TBAB, the yield of 7a increased and found that the optimum TBAB concentration was 1.8 M (entries [8][9][10][11]. To improve the yield further, cationic [TBAB, cetyltrimethylammonium bromide (CTAB)] and anionic [sodium dodecylsulphate (SDS)] surfactants were employed.…”

“…Synthesis of natural products and biologically active polycyclic heterocycles by MCRs is always an organic synthesis challenge [4][5][6][7]. In recent years, the use of hazardous solvents and toxic chemicals is strongly discouraged and synthetic chemists are trying to carry out organic reactions under solvent-free condition or in aqueous medium [8][9][10][11]. Despite of the poor water solubility many organic compounds exhibit, many organic reactions have been efficiently carried out in aqueous medium [12].…”

Unconventional Approaches Involving Cyclodextrin-Based, Self-Assembly-Driven Processes for the Conversion of Organic Substrates in Aqueous Biphasic Catalysis

“…Takacs elaborated metal-directed self-assemblies (Figure 1d) [11] while Ooi developed the synthesis of ion-paired chiral ligands for organometallic catalysis (Figure 1e) [12]. In aqueous media, one of the most relevant strategy relies on hydrophobic effects (Figure 1f) [13,14]. Our group used CDs as platforms to elaborate new water-soluble bidentate ligands ( Figure 2).…”

Peptide-Binding Nanoparticle Materials with Tailored Recognition Sites for Basic Peptides

“…22,23 Although hydrophobic interactions can be strong in water, their usage for selective molecular recognition is not as straightforward as in hydrogen-bonded systems with clearly defined donor–acceptor patterns. 24 …”