Recent advances in nano scaffolds for bone repair

Yi, Huan; Rehman, Fawad Ur; Zhao, Chunqiu; Liu, Bin; He, Nongyue

doi:10.1038/boneres.2016.50

Cited by 221 publications

(112 citation statements)

References 110 publications

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“…Therefore, the G/nHAp/Sr/BG scaffold accelerated the osteogenic and angiogenic processes compared to other groups that might be attributed to sustained‐release of bioactive ions‐ Si (BG) and Sr. It has been shown that biphasic calcium phosphate struts coated with bioactive glass materials enhanced differentiation of human‐derived BMSCs through up‐regulation of Runx2, osteopontin and sialoprotein genes . Another study showed that expression of the osteogenic markers was considerably increased when Sr was incorporated into the collagen/HA scaffold …”

Section: Discussionmentioning

confidence: 99%

Synergistic effect of strontium, bioactive glass and nano‐hydroxyapatite promotes bone regeneration of critical‐sized radial bone defects

et al. 2018

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Critical-sized bone defects constitute a major health issue in orthopedics and usually cause mal-unions due to an inadequate number of migrated progenitor cells into the defect site or their incomplete differentiation into osteogenic precursor cells. The current study aimed to develop an optimized osteoinductive and angiogenic scaffold by incorporation of strontium (Sr) and bioglass (BG) into gelatin/nano-hydroxyapatite (G/nHAp) seeded with bone marrow mesenchymal stem cells to enhance bone regeneration. The scaffolds were fabricated by a freeze-drying technique and characterized in terms of morphology, structure, porosity and degradation rate. The effect of fabricated scaffolds on cell viability, attachment and differentiation into osteoblastic lineages was evaluated under in vitro condition. Micro computed tomography scan, histological and histomorphometric analysis were performed after implantation of scaffolds into the radial bone defects in rat. RT-PCR analysis showed that G/nHAp/BG/Sr scaffold significantly increased the expression level of osteogenic and angiogenic markers in comparison to other groups (P < 0.05). Moreover, the defects treated with the BMSCs-seeded scaffolds showed superior bone formation and mechanical properties compared to the cell-free scaffolds 4 and 12 weeks post-implantation. Finally, the BMSCs-seeded G/nHAp/BG/Sr scaffold showed the greatest bone regenerative capacity which was more similar to autograft. It is concluded that combination of Sr, BG, and nHAp can synergistically enhance the bone regeneration process. In addition, our results demonstrated that the BMSCs have the potential to considerably increase the bone regeneration ability of osteoinductive scaffolds. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018.

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Section: Discussionmentioning

confidence: 99%

Synergistic effect of strontium, bioactive glass and nano‐hydroxyapatite promotes bone regeneration of critical‐sized radial bone defects

et al. 2018

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“…The hysteretic hydrogen absorption/desorption process is coupled with substantial lattice expansion/contraction as the foam converts between Pd and PdHx. Such foams with pristine metal surfaces are also suitable for catalysis as well as biomedical applications, including cell scaffolding [41][42][43] Surface area and pore volume distributions were determined from krypton (Kr) gas adsorption isotherms at -196 °C using BET (Branuer-Emmet-Teller) 48 and BJH (Barrett-Joyner-Halenda) 49 methods, respectively. Hydrogen absorption/desorption measurements were performed using a commercially available precision gas dose controller with forked sample tube and a Calvet-type twin microcalorimeter, described previously.…”

mentioning

confidence: 99%

Tunable Low Density Palladium Nanowire Foams

et al. 2017

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Nanostructured palladium foams offer exciting potential for applications in diverse fields such as catalyst, fuel cell, and particularly hydrogen storage technologies. We have fabricated palladium nanowire foams using a cross-linking and freeze-drying technique. These foams have a tunable density down to 0.1% of the bulk, and a surface area to volume ratio of up to 1,540,000:1. They exhibit highly attractive characteristics for hydrogen storage, in terms of loading capacity, rate of absorption and heat of absorption. The hydrogen absorption/desorption process is hysteretic in nature, accompanied by substantial lattice expansion/contraction as the foam converts between Pd and PdHx.Comment: 17 pages, 4 figure

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“…In comparison with microsized bioceramic particles, nanoscale particles show a higher specific surface area as well as a higher interface area which leads to the formation of a tighter interfacial bonding between the bioceramic and polymeric components. A higher surface area also encourages the attachment of biomolecules and subsequently cells to the scaffold surfaces . Nanosized Bioactive glasses are extensively applied in the preparation of polymer‐ceramic composites in order to enhance biochemical and physiological properties of the scaffold.…”

Section: Discussionmentioning

confidence: 99%

“…A higher surface area also encourages the attachment of biomolecules and subsequently cells to the scaffold surfaces. 42,43 Nanosized Bioactive glasses are extensively applied in the preparation of polymer-ceramic composites in order to enhance biochemical and physiological properties of the scaffold. In fact, BaG phase provides osteoinductive, osteoconductive, and enhanced angiogenic characteristics to the polymeric substrate.…”

Section: Discussionmentioning

confidence: 99%

Bone Regeneration in rat using a gelatin/bioactive glass nanocomposite scaffold along with endothelial cells (HUVECs)

Kazemi

Azami

Johari

et al. 2018

Int J Applied Ceramic Tech

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In our previous study, a three‐dimensional gelatin/bioactive glass nanocomposite scaffold with a total porosity of about 85% and pore sizes ranging from 200 to 500 μm was prepared through layer solvent casting combined with lamination technique. The aim of this study was to evaluate in vitro biocompatibility and in vivo bone regeneration potential of these scaffolds with and without endothelial cells when implanted into a critical‐sized rat calvarial defect. MTT assay, SEM observation, and DAPI staining were used to evaluate cell viability and adhesion in macroporous scaffolds and results demonstrated that the scaffolds were biocompatible enough to support cell attachment and proliferation. To investigate the in vivo osteogenesis of the scaffold, blank scaffolds and endothelial/scaffold constructs were implanted in critical‐sized defects, whereas in control group defects were left untreated. Bone regeneration and vascularization were evaluated at 1, 4, and 12 weeks postsurgery by histological, immunohistochemical, and histomorphometric analysis. It was shown that both groups facilitated bone growth into the defect area but improved bone regeneration was seen with the incorporation of endothelial cells. The data showed that the porous Gel/BaG nanocomposite scaffolds could well support new bone formation, indicating that the proposed strategy is a promising alternative for tissue‐engineered bone defects.

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Recent advances in nano scaffolds for bone repair

Cited by 221 publications

References 110 publications

Synergistic effect of strontium, bioactive glass and nano‐hydroxyapatite promotes bone regeneration of critical‐sized radial bone defects

Synergistic effect of strontium, bioactive glass and nano‐hydroxyapatite promotes bone regeneration of critical‐sized radial bone defects

Tunable Low Density Palladium Nanowire Foams

Bone Regeneration in rat using a gelatin/bioactive glass nanocomposite scaffold along with endothelial cells (HUVECs)

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