Recent advances in nanocarriers for clinical platinum(II) anticancer drugs

Zhang, Jing-Jing; Xu, Qi-Jie; Zhang, Yue; Zhou, Qichen; Lv, Rui; Chen, Zhen; He, Weijiang

doi:10.1016/j.ccr.2024.215676

Coordination Chemistry Reviews

2024

DOI: 10.1016/j.ccr.2024.215676

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Recent advances in nanocarriers for clinical platinum(II) anticancer drugs

Jing-Jing Zhang,

Qi-Jie Xu,

Yue Zhang

et al.

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Cited by 6 publications

References 103 publications

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Copper(I) Complexes With Phenanthroline‐Functionalized NHC Ligands Achieve Effective Anticancer Activity via Mitochondrial and Endoplasmic Reticulum Stress

Chen,

Zheng,

Rao

et al. 2024

Applied Organom Chemis

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Copper complexes exhibit promising anticancer properties, which can be further promoted by suitable ligands. In this study, we synthesized and investigated the anticancer effects of three copper(I) complexes with N‐heterocyclic carbene (NHC) ligands derived from phenanthroline‐functionalized imidazole salts. The synthesis of these NHC‐copper(I) complexes (Cu1‐Cu3) was meticulously characterized using NMR and elemental analysis; their crystal structures were further delineated by X‐ray diffraction. Our findings illustrate the unique geometric configurations of these complexes: Cu1 features a dinuclear arrangement with off‐linear geometry; Cu2 and Cu3 are characterized by a bi‐copper core stabilized by two phenanthroline‐modified carbene ligands. Crucially, in vitro cytotoxic evaluations revealed that these complexes possess suitability anticancer activity. Among them, Cu2 exhibited enhanced cytotoxicity activity, achieving a half‐maximal inhibitory concentration (IC50) of 4.36 ± 0.25 μM in colon cancer cell line HCT‐116, markedly surpassing the efficacy of cisplatin. Subsequent investigations elucidated that Cu2 notably increases intracellular reactive oxygen species (ROS) levels and induces mitochondrial membrane depolarization and endoplasmic reticulum stress, leading to oxidative stress‐mediated apoptosis of colon cancer cells.

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Copper(I) Complexes With Phenanthroline‐Functionalized NHC Ligands Achieve Effective Anticancer Activity via Mitochondrial and Endoplasmic Reticulum Stress

Chen,

Zheng,

Rao

et al. 2024

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

Functionality developments in montmorillonite nanosheet: Properties, preparation, and applications

Wang,

Wu,

Chang

et al. 2024

Chemical Engineering Journal

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Impacts of designed vanillic acid-polymer-magnetic iron oxide nanocomposite on breast cancer cells

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Saifullah

et al. 2024

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Recent advances in nanocarriers for clinical platinum(II) anticancer drugs

Cited by 6 publications

References 103 publications

Copper(I) Complexes With Phenanthroline‐Functionalized NHC Ligands Achieve Effective Anticancer Activity via Mitochondrial and Endoplasmic Reticulum Stress

Copper(I) Complexes With Phenanthroline‐Functionalized NHC Ligands Achieve Effective Anticancer Activity via Mitochondrial and Endoplasmic Reticulum Stress

Functionality developments in montmorillonite nanosheet: Properties, preparation, and applications

Impacts of designed vanillic acid-polymer-magnetic iron oxide nanocomposite on breast cancer cells

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