Recent advances in nanotechnology for eradicating bacterial biofilm

Sahli, Célia; Moya, Sergio; Lomas, John S.; Gravier‐Pelletier, Christine; Briandet, Romain; Hémadi, Miryana

doi:10.7150/thno.67296

Cited by 82 publications

(52 citation statements)

References 183 publications

(186 reference statements)

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“…At the same time, the surfaces are able to accumulate pathogenic microorganisms, thus inducing infectious diseases [ 16 , 17 , 18 , 19 ]. In order to minimize the chance of infection, the surfaces are modified to give them antibacterial properties [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Biocidal Coatings from Complexes of Carboxylated Latex Particles and a Linear Cationic Polymer

et al. 2022

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A linear polycation, poly(diallyldimethylammonium chloride), electrostatically interacts with anionic latex particles from a carboxylated butadiene–styrene copolymer in aqueous solution thus forming an interpolyelectrolyte complex. A mutual neutralization of oppositely charged latex and polycation groups occurs at W = latex/polycation = 50 wt/wt ratio. At W = 27, an ultimate polycation adsorption is reached, resulting in the formation of positive polycomplex particles, while at W ˂ 27, two-component systems are formed composed of positive polycomplex particles and free polycation. A film created from the W = 12 formulation shows a high toxicity to Gram-positive and Gram-negative bacteria and yeast. Repeated washing the film leads to partial removal of polycation and a 50% decrease in the activity of the film only towards Gram-negative Pseudomonas aeruginosa. The results indicate the potential for use of the mixed polymer formulations for the fabrication of antimicrobial films and coatings.

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Section: Introductionmentioning

confidence: 99%

Biocidal Coatings from Complexes of Carboxylated Latex Particles and a Linear Cationic Polymer

et al. 2022

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“…The World Health Organization (WHO) has ranked bacterial infections among its top 10 research priorities. Worldwide, the mortality associated with antibiotic-resistant infections is estimated at 7 million deaths per year, and it is anticipated to increase to 10 million deaths per year in 2050 if efficient therapies are not found [ 1 , 2 ]. Furthermore, it is predicted that the cost of treatment related to bacterial infections in Europe will rise by more than EUR 1.5 billion/year as a result of the spread and increase of bacterial diseases [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Antibiofilm Activity of Biocide Metal Ions Containing Bioactive Glasses (BGs): A Mini Review

Atkinson

2022

Bioengineering

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One of the major clinical issues during the implantation procedure is the bacterial infections linked to biofilms. Due to their tissue localization and the type of bacteria involved, bacterial infections at implant sites are usually difficult to treat, which increases patient morbidity and even mortality. The difficulty of treating biofilm-associated infections and the emergence of multidrug-resistant bacteria are further challenges for the scientific community to develop novel biomaterials with excellent biocompatibility and antibacterial properties. Given their ability to stimulate bone formation and have antibacterial properties, metal ion-doped bioactive glasses (BGs) have received considerable research. This mini review aims to be successful in presenting the developments made about the role of biocide metal ions incorporated into BGs against the development of bacterial biofilms and the spread of nosocomial diseases.

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“…It is estimated that up to 7 million people worldwide die each year from antibiotic resistance. If no effective therapy is found, the death rate could rise to 10 million per year by 2050 [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Coumarin-Encapsulated Solid Lipid Nanoparticles as an Effective Therapy against Methicillin-Resistant Staphylococcus aureus

et al. 2022

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Bacterial infections caused by antibiotic-resistant pathogens are a significant public health problem. This is because the transmission of infectious diseases is shifting, and new antibiotic-resistant strains of bacteria are emerging. The development of biofilms that are resistant to antibiotics poses another hurdle to drugs and treatment alternatives. Therefore, there is an urgent need to develop innovative strategies to effectively eliminate antibiotic-resistant microorganisms effectively. Natural coumarins have broad spectrum bioactivity and the potential for lower resistance. Coumarin is a secondary metabolite found in certain plants, fungi, and bacteria. It is highly effective against methicillin-resistant Staphylococcus aureus (MRSA). Therefore, coumarin can be used as an alternative to combat MRSA. However, most antibacterial agents lack selective targeting of pathological sites, limiting the efficacy of their antibacterial activity. Efficient MRSA treatments can be achieved through nanoparticle (NPs)-based targeted therapies. To address this challenge, a novel coumarin-loaded solid lipid nanocarrier for MRSA was developed to overcome this challenge. The developed systems exhibited a particle size of 138.5 ± 76.06 nm and a polydispersity index (PDI) of 0.245 ± 0.00. The zeta potential of coumarin-loaded SLNs was reported to be −22.2 ± 8.15 mV with a spherical shape. The encapsulation efficiency of coumarin was reported to be 63.09 ± 3.46% in the final formulation. The developed formulation was biocompatible with a minimum inhibitory concentration (MIC) of 1.08 µg/ml. This study suggests that coumarin-loaded SLNs can effectively treat MRSA infections.

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Recent advances in nanotechnology for eradicating bacterial biofilm

Cited by 82 publications

References 183 publications

Biocidal Coatings from Complexes of Carboxylated Latex Particles and a Linear Cationic Polymer

Biocidal Coatings from Complexes of Carboxylated Latex Particles and a Linear Cationic Polymer

Antibiofilm Activity of Biocide Metal Ions Containing Bioactive Glasses (BGs): A Mini Review

Coumarin-Encapsulated Solid Lipid Nanoparticles as an Effective Therapy against Methicillin-Resistant Staphylococcus aureus

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