Recent advances in peptide nucleic acid for cancer bionanotechnology

Sridevi

2020

Engineering Reports

Peptide Nucleic Acid (PNA) are DNA/RNA synthetic analogs with 2-([2-aminoethyl] amino) acetic acid backbone. They partake unique antisense and antigene properties, just due to its inhibitory effect on transcription and translation; they also undergo complementary binding to RNA/DNA with high affinity and specificity. Hence, to date, many methods utilizing PNA for diagnosis and treatment of various diseases namely cancer, AIDS, human papillomavirus, and so on, have been designed and developed. They are being used widely in polymerase chain reaction modulation/mutation, fluorescent in-situ hybridization, and in microarray as a probe; they are also utilized in many in-vitro and in-vivo assays and for developing micro and nano-sized biosensor/chip/array technologies. Earlier reviews, focused only on PNA properties, structure, and modifications related to diagnostics and therapeutics; our review emphasizes on PNA properties and synthesis along with its potential applications in diagnosis and therapeutics. Furthermore, prospects in biomedical applications of PNAs are being discussed in depth.

Section: Applications Of Pnamentioning

confidence: 99%

Potential applications of peptide nucleic acid in biomedical domain

Sridevi

2020

Engineering Reports

“…The annealed sample has the maximum luminous intensity, which may be attributed to the full desorption of cit 3− groups from the sample and the large increase in crystallinity of the YVO 4 phosphor. However, the photoluminescence emission spectra of all samples, except for Na 3 cit, have weak peaks located at 481 and 573 nm, which may be due to a few Dy 3+ ions present in the Y 2 O 3 raw materials [15]. The emission intensity of the samples at pH = 3, 7, and 10 using cit 3− :Y 3+ of 2:1 show that the amount of cit 3− groups effectively adsorbed on YVO 4 particles reduces gradually, as well as the control of morphologies of the samples; whereas, the luminous intensity of the samples increases gradually with the increase in pH value.…”

Section: Luminescent Propertiesmentioning

confidence: 93%

Effect of Trisodium Citrate on the Morphology and Luminescence Properties of Hydrothermally Synthesized YVO₄Phosphor

2016

YVO4 phosphors with different morphologies were synthesized by trisodium citrate (Na3cit) surfactant-assisted hydrothermal process. Effects of molar ratio of cit 3− to Y 3+ and pH value of reaction solution were intensively investigated on the morphologies, structures and luminescence properties of YVO4 phosphor. The morphologies of the YVO4 particles can be effectively controlled in strong acidic and strong alkaline environment by affecting the adsorption of cit 3− on the (001) crystal plane of YVO4. Strong acidic condition resulted into excessive adsorption of cit 3− groups on the YVO4 phosphor, which annihilated the superior luminescence of YVO4 phosphors. On the contrary, strong alkaline condition does not result into the adsorption of cit 3− groups. The synthesized YVO4 phosphor without adsorption of cit 3− groups showed superior luminescence even though the effective control of the morphology in alkaline condition is not so good as in strong acidic condition.

“…Accordingly, DNA's deepen understanding may be a prerequisite in clarification of such organism metabolism [3][4][5]. To effectively scrutinize it, in general and in the most usages, complementary DNA sequences coupling specifically with targeted oligonucleotides in organisms have been designed and explored directly in some biological system which is in inquiry [6][7][8]. A number of methodologies for enhanced signaling of specific DNA hybridization have been ingeniously contrived, in which there are a simple fluorescent detection of antisense hybridizations and an elaborate kinetics of strand displacements [9,10].…”

Section: Introductionmentioning

confidence: 99%

Hybrid material of structural DNA with inorganic compound: synthesis, applications, and perspective

et al. 2020

Owing to its precise manipulation in nanoscale, DNA as a genetic code becomes a promising and generic material in lots of nanotechnological outstanding exploitations. The nanoscale assembly of nucleic acids in aqueous solution has showed very remarkable capability that is not achievable from any other material resources. In the meantime, their striking role played by effective intracellular interactions have been identified, making these more attractive for a variety of biological applications. Lately, a number of interesting attempts have been made to augment their marvelous diagnostic and therapeutic capabilities, as being integrated with inorganic compounds involving gold, iron oxide, quantum dot, upconversion, etc. It was profoundly studied how structural DNA-inorganic hybrid materials have complemented with each other in a synergistic way for better-graded biological performances. Such hybrid materials consisting of both structural DNAs and inorganics are gradually receiving much attention as a practical and futureoriented material substitute. However, any special review articles highlighting the significant and innovative materials have yet to be published. At the first time, we here demonstrate novel hybrid complexes made of structural DNAs and inorganics for some practical applications.