Recent advances in plasmonic Prussian blue-based SERS nanotags for biological application

Liu, Yaqin; Zhu, Wei; Hu, Jiming; Shen, Aiguo

doi:10.1039/d1na00464f

Cited by 18 publications

(8 citation statements)

References 104 publications

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“…Then, by mixing the SERS substrate with the above alkali-treated solution, a distinctive SERS signal at 2083 cm –1 was obtained in the “biological Raman-silent region”, where the signal interference of biological endogenous molecules was effectively circumvented …”

Section: Resultsmentioning

confidence: 99%

“…T hen, by mixing the SERS substrate with the above alkalitreated solution, a distinctive SERS signal at 2083 cm −1 was obtained in the "biological Raman-silent region", where the signal interference of biological endogenous molecules was effectively circumvented. 34 Meanwhile, substrate material is also a key factor that determines the signal enhancement. It is well known that nanosized noble metal particles (typically Au NP or Ag NP) are highly SERS-active plasmonic substrates, and have been used to significantly enhance the Raman signal.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

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Ultrasensitive CRISPR/Cas12a-Driven SERS Biosensor for On-Site Nucleic Acid Detection and Its Application to Milk Authenticity Testing

Pan

Liu

Wang

et al. 2022

J. Agric. Food Chem.

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An ultrasensitive surface-enhanced Raman scattering (SERS) biosensor driven by CRISPR/Cas12a was proposed for on-site nucleic acid detection. We tactfully modified single-strand DNA (ssDNA) with a target-responsive Prussian blue (PB) nanolabel to form a probe and fastened it in the microplate. Attributed to the specific base pairing and highly efficient trans-cleavage ability of the CRISPR/Cas12a effector, precise target DNA recognition and signal amplification can be achieved, respectively. In the presence of target DNA, trans-cleavage towards the probe was activated, leading to the release of a certain number of PB nanoparticles (NPs). Then, these free PB NPs would be removed. Under alkali treatment, the breakdown of the remaining PB NPs in the microplate was triggered, producing massive ferricyanide anions (Fe(CN) 6 4− ), which could exhibit a unique characteristic Raman peak that was located in the "biological Raman-silent region". By mixing the alkali-treated solution with the SERS substrate, Au@Ag core−shell NP, the concentration of the target DNA was finally exhibited as SERS signals with undisturbed background, which can be detected by a portable Raman spectrometer. Importantly, this strategy could display an ultralow detection limit of 224 aM for target DNA. Furthermore, by targeting cow milk as the adulterated ingredient in goat milk, the proposed biosensor was successfully applied to milk authenticity detection.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Materials and Methodsmentioning

confidence: 99%

Ultrasensitive CRISPR/Cas12a-Driven SERS Biosensor for On-Site Nucleic Acid Detection and Its Application to Milk Authenticity Testing

Pan

Liu

Wang

et al. 2022

J. Agric. Food Chem.

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“…In recent years, surface-enhanced Raman spectroscopy (SERS)-based biosensor has acted as a promising alternative in food safety, due to its high sensitivity, specificity and multiplexing detection ability [ 3 , 6 ]. As the core component of SERS-based biosensor, SERS probes are normally composed of metal nanostructures (enhanced substrates), such as gold nanoparticles (Au NPs) and Raman reporters (RRs) [ 7 ]. RRs (such as 4-mercaptobenzoic acid, 4-mercaptopyridine, 4-nitrothiophenol, etc.)…”

Section: Introductionmentioning

confidence: 99%

An Alkyne-Mediated SERS Aptasensor for Anti-Interference Ochratoxin A Detection in Real Samples

Wang

Chen

et al. 2022

Foods

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Avoiding interference and realizing the precise detection of mycotoxins in complex food samples is still an urgent problem for surface-enhanced Raman spectroscopy (SERS) analysis technology. Herein, a highly sensitive and specific aptasensor was developed for the anti-interference detection of Ochratoxin A (OTA). In this aptasensor, 4-[(Trimethylsilyl) ethynyl] aniline was employed as an anti-interference Raman reporter to prove a sharp Raman peak (1998 cm−1) in silent region, which could avoid the interference of food bio-molecules in 600–1800 cm−1. 4-TEAE and OTA-aptamer were assembled on Au NPs to serve as anti-interference SERS probes. Meanwhile, Fe3O4 NPs, linked with complementary aptamer (cApts), were applied as capture probes. The specific binding of OTA to aptamer hindered the complementary binding of aptamer and cApt, which inhibited the binding of SERS probes and capture probes. Hence, the Raman responses at 1998 cm−1 were negatively correlated with the OTA level. Under the optimum condition, the aptasensor presented a linear response for OTA detection in the range of 0.1–40 nM, with low detection limits of 30 pM. In addition, the aptasensor was successfully applied to quantify OTA in soybean, grape and milk samples. Accordingly, this anti-interference aptasensor could perform specific, sensitive and precise detection of OTA in real samples, and proved a reliable reference strategy for other small-molecules detection in food samples.

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“…In the past few years, surface-enhanced Raman scattering (SERS) has gained increasing popularity in authentication, , detections, , and diagnostics. , Apart from its high sensitivity, SERS possesses intrinsic advantages in comparison with other spectral techniques, including highly resolved spectral bands, alleviated photobleaching, as well as operation over a wide range of excitation wavelengths. These essential features suggest the capability of SERS fingerprint in barcoding and anticounterfeiting applications. − As an optical technique that depends on electromagnetic field enhancement from plasmonic nanostructures, preparation of plasmonic nanostructures becomes an indispensable step toward those emerging applications. , Although tremendous efforts have been devoted to fabrication of effective plasmonic substrates by self-assembly, − direct wield and growth of plasmonic building blocks as secondary structural domains suggests a straightforward route to plasmonic nanostructures bearing intense built-in hotspots. , However, this pathway has proved to be very difficult to achieve because nanocrystal growth principally yields symmetrical nanocrystals with simple morphologies due to thermodynamic preference.…”

Section: Introductionmentioning

confidence: 99%

“…In the past few years, surface-enhanced Raman scattering (SERS) has gained increasing popularity in authentication, 1,2 detections, 3,4 and diagnostics. 5,6 Apart from its high sensitivity, SERS possesses intrinsic advantages in comparison with other spectral techniques, including highly resolved spectral bands, alleviated photobleaching, as well as operation over a wide range of excitation wavelengths. These essential features suggest the capability of SERS fingerprint in barcoding and anticounterfeiting applications.…”

Section: ■ Introductionmentioning

confidence: 99%

Hierarchical Au Nanoisland Arrays for Anticounterfeiting Surface-Enhanced Raman Scattering Stamps

Liu

Shi

et al. 2021

ACS Appl. Nano Mater.

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Plasmonic nanostructures of hierarchy allow for the integration of the functions of different domains and, importantly, provide built-in nanogaps and hotspots due to the intrinsic coupling effect. Although they are badly needed for a range of applications, including surface-enhanced spectroscopies, chem/biosensing, and others, simple and fast preparation of plasmonic hierarchical nanostructures remains a challenging goal. Here, the growth of hierarchical Au nanoisland arrays in a reactant in/target produced fashion is communicated. By a single-step quick injection, uniform Au nanoisland arrays with intense built-in hotspots could be produced within minutes through competitive balance between the reaction rate and seed surface passivation using a strong binding ligand. The experimental results and theoretical simulations revealed a strong electromagnetic enhancement effect of the Au nanoisland arrays. Stable anticounterfeiting SERS labels were realized by stamping the nanoisland array-based ink on an ordinary paper, by which dyes of similar appearance can be easily discriminated.

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Recent advances in plasmonic Prussian blue-based SERS nanotags for biological application

Abstract: The reliability and reproducibility of surface-enhanced Raman scattering (SERS) technology is still a great challenge in bio-related analysis.

Cited by 18 publications

References 104 publications

Ultrasensitive CRISPR/Cas12a-Driven SERS Biosensor for On-Site Nucleic Acid Detection and Its Application to Milk Authenticity Testing

Ultrasensitive CRISPR/Cas12a-Driven SERS Biosensor for On-Site Nucleic Acid Detection and Its Application to Milk Authenticity Testing

An Alkyne-Mediated SERS Aptasensor for Anti-Interference Ochratoxin A Detection in Real Samples

Hierarchical Au Nanoisland Arrays for Anticounterfeiting Surface-Enhanced Raman Scattering Stamps

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