Recent advances in polymer-based drug delivery systems for local anesthetics

Wang, Bo; Wang, Shuo; Zhang, Qi; Deng, Yi-Xuan; Li, Xiang; Peng, Liangyu; Zuo, Xianghao; Piao, Meihua; Kuang, Xin; Sheng, Shihou; Yu, Yingjie

doi:10.1016/j.actbio.2019.05.044

Cited by 68 publications

(40 citation statements)

References 103 publications

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“…A drug delivery system is a technical system that comprehensively regulates the distribution of drugs in a living body in terms of delivery space, time, and dosage [149]. The goal is to deliver the right amount of the drug to the right place at the right time, increasing drug bioavailability and reducing costs and side effects [150].…”

Section: Application Of Chitosan Derivative Nanoparticles In Drug Delmentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

649

326

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Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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Section: Application Of Chitosan Derivative Nanoparticles In Drug Delmentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

649

326

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“…Over several decades, electrostatic nanocomplex system using biocompatible polymers and/or lipids has received much attention for the design and development of sustained release parenteral therapeutic agents. [18][19][20][21] The electrostatic interaction between a drug and an oppositely charged polymer results in the formation of a complex, impeding the release of drugs from the association. This complex does not require complicated manufacturing processes nor the use of chemical crosslinking agents, thereby reducing possible toxicity and other undesirable effects of the reagents.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, special caution is required during storage and prior to administration, 17 since the encapsulated drug can readily cross the liposomal membrane. Over several decades, electrostatic nanocomplex system using biocompatible polymers and/or lipids has received much attention for the design and development of sustained release parenteral therapeutic agents 18–21 . The electrostatic interaction between a drug and an oppositely charged polymer results in the formation of a complex, impeding the release of drugs from the association.…”

Section: Introductionmentioning

confidence: 99%

Nanocomplex System of Bupivacaine with Dextran Sulfate for Parenteral Prolonged Delivery

Kim

Park

Kang

2020

Bulletin Korean Chem Soc

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An electrostatic complex system of bupivacaine (BUP), an amide-type analgesic agent, with an oppositely charged polymer was designed for parenteral sustained delivery. The complex was prepared by admixing the drug (0.25-1.0% w/v) with different anionic polymers (dextran sulfate, carboxymethylcellulose, or carboxymethyl dextran, 1.0-5.0% w/v), and then adding calcium ion (0-1.0% w/v) as the noncovalent crosslinking agent. Negatively charged complexes ranging from 10 to 2000 nm were formed after the positively charged BUP molecules amalgamated with the polymers after gentle agitation. Drug released from the complex was markedly sustained either by increasing the polymer to drug ratio, or by increasing the calcium ion content. The optimized nanocomplex consisted of the drug, dextran sulfate, and calcium ion at the ratio of 1:20:20 w/w/w, which supplied a sustained release profile over 7 days. Therefore, novel nanocomplex is expected to be an effective tool to provide a sustained release of the analgesic agent.

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“…Due to their peculiar structures, they offer great possibilities for the coating of nanoparticles and drug delivery/selectivity enhancement. When located on a particle's surface they are able to give them specific properties and functionalities: the surface modification is in fact crucial for the biological response and to improve the therapeutic efficiency [77][78][79]. Examples of polymers that can be used include polyethylene glycol, polycaprolactone, polysorbate, polylactic acid, dextran, chitosan, and many others [78][79][80][81].…”

Section: Polymersmentioning

confidence: 99%

Coating and Functionalization Strategies for Nanogels and Nanoparticles for Selective Drug Delivery

Pinelli

Perale

Rossi

2020

Gels

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Drug delivery is a fascinating research field with several development opportunities. Great attention is now focused on colloidal systems, nanoparticles, and nanogels and on the possibility of modifying them in order to obtain precise targeted drug delivery systems. The aim of this review is to give an overview of the main available surface functionalization and coating strategies that can be adopted in order to modify the selectivity of the nanoparticles in the delivery process and obtain a final system with great targeted drug delivery ability. We also highlight the most important fields of application of these kinds of delivery systems and we propose a comparison between the advantages and disadvantages of the described functionalization strategies.

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Recent advances in polymer-based drug delivery systems for local anesthetics

Cited by 68 publications

References 103 publications

Chitosan Derivatives and Their Application in Biomedicine

Chitosan Derivatives and Their Application in Biomedicine

Nanocomplex System of Bupivacaine with Dextran Sulfate for Parenteral Prolonged Delivery

Coating and Functionalization Strategies for Nanogels and Nanoparticles for Selective Drug Delivery

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