Recent Advances in Polymeric Implants

Ahmed, Kawther K.; Tamer, Manar Adnan; Ghareeb, Mowafaq M.; Salem, Aliasger K.

doi:10.1208/s12249-019-1510-0

Cited by 23 publications

(11 citation statements)

References 82 publications

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“…To address the challenge of specific release rates or on-demand release, polymeric implants and microchips were developed for sc. administration [146]. Implants are able to release drug substances over different periods of time, depending on the cancer type and treatment schedule.…”

Section: Sc Delivery Routementioning

confidence: 99%

Challenges and Opportunities in the Delivery of Cancer Therapeutics: Update on Recent Progress

et al. 2020

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Global cancer prevalence has continuously increased in the last decades despite substantial progress achieved for patient care. Cancer is no longer recognized as a singular disease but as a plurality of different ones, leading to the important choice of the drug administration route and promoting the development of novel drug-delivery systems (DDS). Due to their structural diversity, therapeutic cancer drugs present specific challenges in physicochemical properties that can adversely affect their efficacy and toxicity profile. These challenges are addressed by innovative DDS to improve bioavailability, pharmacokinetics and biodistribution profiles. Here, we define the drug delivery challenges related to oral, intravenous, subcutaneous or alternative routes of administration, and review innovative DDS, marketed or in development, that answer those challenges.

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Section: Sc Delivery Routementioning

confidence: 99%

Challenges and Opportunities in the Delivery of Cancer Therapeutics: Update on Recent Progress

et al. 2020

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“…Materials used to successfully produce bioprinted knee menisci and IVD's need to exhibit certain characteristics, such as biocompatibility to minimize immune response in the body; similar mechanical properties as native cartilage tissue to provide support to high load bearing regions such as in meniscus repair; and capability of promoting cell adhesion and proliferation, leading to cartilage tissue regeneration (Ahmed et al, 2019). Bioink components such as transforming growth factor beta-3 (TGF-β3) and bone morphogenetic protein-6 (BMP-6), can bind to cellular receptors, leading to cell differentiation and proliferation (Roseti et al, 2018).…”

Section: Bioinksmentioning

confidence: 99%

3D Bioprinted Implants for Cartilage Repair in Intervertebral Discs and Knee Menisci

Perera

Ivone

Natekin

et al. 2021

Front. Bioeng. Biotechnol.

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Cartilage defects pose a significant clinical challenge as they can lead to joint pain, swelling and stiffness, which reduces mobility and function thereby significantly affecting the quality of life of patients. More than 250,000 cartilage repair surgeries are performed in the United States every year. The current gold standard is the treatment of focal cartilage defects and bone damage with nonflexible metal or plastic prosthetics. However, these prosthetics are often made from hard and stiff materials that limits mobility and flexibility, and results in leaching of metal particles into the body, degeneration of adjacent soft bone tissues and possible failure of the implant with time. As a result, the patients may require revision surgeries to replace the worn implants or adjacent vertebrae. More recently, autograft – and allograft-based repair strategies have been studied, however these too are limited by donor site morbidity and the limited availability of tissues for surgery. There has been increasing interest in the past two decades in the area of cartilage tissue engineering where methods like 3D bioprinting may be implemented to generate functional constructs using a combination of cells, growth factors (GF) and biocompatible materials. 3D bioprinting allows for the modulation of mechanical properties of the developed constructs to maintain the required flexibility following implantation while also providing the stiffness needed to support body weight. In this review, we will provide a comprehensive overview of current advances in 3D bioprinting for cartilage tissue engineering for knee menisci and intervertebral disc repair. We will also discuss promising medical-grade materials and techniques that can be used for printing, and the future outlook of this emerging field.

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“…Materials used in 3D printed parenteral constructs need to be biocompatible to minimize immune response in the body, in addition to demonstrating suitable mechanical properties to ensure sufficient printability. Considerations such as ability to promote cell adhesion and proliferation should also be taken into account for parenteral applications including bone and tissue scaffolds [ 58 ]. Some materials commonly used in 3D printed parenteral constructs are listed in Tables I and II .…”

Section: Key Aspects Of Fabricating Parenteral Dosage Forms Via 3d Printingmentioning

confidence: 99%

Recent Advances in 3D Printing for Parenteral Applications

Ivone

Yang

Shen

2021

AAPS J

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3D printing has emerged as an advanced manufacturing technology in the field of pharmaceutical sciences. Despite much focus on enteral applications, there has been a lack of research focused on potential benefits of 3D printing for parenteral applications such as wound dressings, biomedical devices, and regenerative medicines. 3D printing technologies, including fused deposition modeling, vat polymerization, and powder bed printing, allow for rapid prototyping of personalized medications, capable of producing dosage forms with flexible dimensions based on patient anatomy as well as dosage form properties such as porosity. Considerations such as printing properties and material selection play a key role in determining overall printability of the constructs. These parameters also impact drug release kinetics, and mechanical properties of final printed constructs, which play a role in modulating immune response upon insertion in the body. Despite challenges in sterilization of printed constructs, additional post-printing processing procedures, and lack of regulatory guidance, 3D printing will continue to evolve to meet the needs of developing effective, personalized medicines for parenteral applications.

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Recent Advances in Polymeric Implants

Cited by 23 publications

References 82 publications

Challenges and Opportunities in the Delivery of Cancer Therapeutics: Update on Recent Progress

Challenges and Opportunities in the Delivery of Cancer Therapeutics: Update on Recent Progress

3D Bioprinted Implants for Cartilage Repair in Intervertebral Discs and Knee Menisci

Recent Advances in 3D Printing for Parenteral Applications

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