Recent Advances in Renal Clearable Inorganic Nanoparticles for Cancer Diagnosis

Yin, Ruiqi; Zhang, Xiaochen; Ge, Jianxian; Wen, Ling; Chen, Lei; Zeng, Jianfeng; Li, Zhen; Gao, Mingyuan

doi:10.1002/ppsc.202000270

Cited by 12 publications

(9 citation statements)

References 164 publications

(214 reference statements)

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“…Kidneys eliminate small-sized nanoparticles by glomerular filtration, which is strictly dependent on the size, surface modification, morphology, and surface charge of the nanoparticles. 76 Here, BT NPs4 that possessed a smaller size could easily permeate through the fenestrated glomerular endothelium (pore diameter was ∼80− 100 nm) 77 and then preferentially accumulate in the kidney (Figures S29B and S30B). Further, the clearance efficiency of smaller-sized BT NPs4 was obviously higher than that of larger-sized BT NPs1 (1.54 vs 3.98 μg at day 4) (Figure S29C).…”

Section: Resultsmentioning

confidence: 94%

“…We observed that BT NPs1 with a relatively large size tended to accumulate in the liver (Figures S29B and S30A). Kidneys eliminate small-sized nanoparticles by glomerular filtration, which is strictly dependent on the size, surface modification, morphology, and surface charge of the nanoparticles . Here, BT NPs4 that possessed a smaller size could easily permeate through the fenestrated glomerular endothelium (pore diameter was ∼80–100 nm) and then preferentially accumulate in the kidney (Figures S29B and S30B).…”

Section: Resultsmentioning

confidence: 99%

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A Universally EDTA-Assisted Synthesis of Polytypic Bismuth Telluride Nanoplates with a Size-Dependent Enhancement of Tumor Radiosensitivity and Metabolism In Vivo

et al. 2022

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Bismuth telluride (Bi 2 Te 3 ) is an available thermoelectric material with the lowest band gap among bismuth chalcogenides, revealing a broad application in photocatalysis. Unfortunately, its size and morphology related to a radio-catalysis property have rarely been explored. Herein, an ethylenediaminetetraacetic acid (EDTA)-assisted hydrothermal strategy was introduced to synthesize polytypic Bi 2 Te 3 nanoplates (BT NPs) that exhibit sizedependent radio-sensitization and metabolism characteristics in vivo. By simply varying the molar ratio of EDTA/Bi 3+ during the reaction, BT NPs with different sizes and morphologies were obtained. EDTA acting as chelating agent and "capping" agent contributed to the homogeneous growth of BT NPs by eliminating dangling bonds and reducing the surface energy of different facets. Further analyzing the size-dependent radio-sensitization mechanism, largersized BT NPs generated holes that preferentially catalyzed the conversion of OH − to •OH when irradiated with X-rays, while the smaller-sized BT NPs exhibited faster decay kinetics producing higher 1 O 2 levels to enhance radiotherapy effects. A metabolomic analysis revealed that larger-sized BT NPs were oxidized into Bi(O x ) in the liver via a citrate cycle pathway, whereas smaller-sized BT NPs accumulated in the kidney and were excreted in urine in the form of ions by regulating the metabolism of glutamate. In a cervical cancer model, BT NPs combined with X-ray irradiation significantly antagonized tumor suppression through the promotion of apoptosis in tumor cells. Consequently, in addition to providing a prospect of BT NPs as an efficient radio-sensitizer to boost the tumor radiosensitivity, we put forth a strategy that can be universally applied in synthesizing metal chalcogenides for catalysis-promoted radiotherapy.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

A Universally EDTA-Assisted Synthesis of Polytypic Bismuth Telluride Nanoplates with a Size-Dependent Enhancement of Tumor Radiosensitivity and Metabolism In Vivo

et al. 2022

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“…When the hydrated particle sizes are less than 10 nm, nanomaterials will be quickly cleared by the kidney metabolism in the body. On the contrary, when the hydrated particle sizes are larger than 100 nm, nanomaterials are easily marked and eliminated by the immune system, which severely limits the bioavailability of the nanoparticles, thus affecting the imaging and therapeutic effects. , At the same time, when the reaction feed ratio is 6:1, the load rate of Fe(III) is the highest, reaching 18% (Figure b). The content of Fe(III) directly affects the MRI function, so the FePPy-NH 2 NPs obtained at a feed ratio of 6:1 were selected for subsequent experiments and show an average diameter of 54.3 nm under TEM (Figure c).…”

Section: Resultsmentioning

confidence: 99%

Fe(III)-Doped Polyaminopyrrole Nanoparticle for Imaging-Guided Photothermal Therapy of Bladder Cancer

Liu

Zhang

Hao

et al. 2022

ACS Biomater. Sci. Eng.

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Clinically, the surgical treatment of bladder cancer often faces the problem of tumor recurrence, and the surgical treatment combined with postoperative chemotherapy to inhibit tumor recurrence also faces high toxicity and side effects. Therefore, the need for innovative bladder cancer treatments is urgent. For the past few years, with the development of nano science and technology, imaging-guided therapy using nanomaterials with both imaging and therapy functions has shown great advantages and can not only identify the locations of the tumors but also exhibit biodistributions of nanomaterials in the tumors, significantly improving the accuracy and efficacy of treatment. In this work, we synthesized Fe(III)-doped polyaminopyrrole nanoparticles (FePPy-NH2 NPs). With low cytotoxicity and a blood circulation half-life of 7.59 h, high levels of FePPy-NH2 NPs accumulated in bladder tumors, with an accumulation rate of up to 5.07%ID/g. The coordination of Fe(III) and the amino group in the structure can be used for magnetic resonance imaging (MRI), whereas absorption in the near-infrared region can be applied to photoacoustic imaging (PAI) and photothermal therapy (PTT). MRI and PAI accurately identified the location of the tumor, and based on the imaging data, laser irradiation was employed accurately. With a high photothermal conversion efficiency of 44.3%, the bladder tumor was completely resected without recurrence. Hematological analysis and histopathological analysis jointly confirmed the high level of safety of the experiment.

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“…As such, it is anticipated that the ultrasmall luminescent nanoprobes will serve as potent PL imaging tools and provide a solution to in vivo imaging. [33][34][35] We should note that some specific challenges may also arise in the design and in vivo application of ultrasmall nanoprobes such as insufficient tumor targeting efficacy.…”

Section: Huanghao Yangmentioning

confidence: 99%

“…Even so, ultrasmall nanoprobes may have relatively low uptake in tumors than large-sized NPs due to their moleculelike renal clearance and fast blood clearance. 21,110,111 Impressively, some strategies have been presented to augment the tumor accumulation efficacy of ultrasmall nanoprobes. [112][113][114][115] For example, metal NPs can be synthesized in situ on template proteins (e.g., albumin), which may allow enhanced blood circulation and tumor accumulation effects than smallligand-capped counterparts (Fig.…”

Section: Ultrasmall Nanoprobes Versus Molecular and Large-sized Probesmentioning

confidence: 99%

Emerging ultrasmall luminescent nanoprobes forin vivobioimaging

Wei

Yao

et al. 2023

Chem. Soc. Rev.

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Recent Advances in Renal Clearable Inorganic Nanoparticles for Cancer Diagnosis

Abstract: (China). Her major research interest focuses on iron oxide nanoimaging probes and clinical conversion applications.

Cited by 12 publications

References 164 publications

A Universally EDTA-Assisted Synthesis of Polytypic Bismuth Telluride Nanoplates with a Size-Dependent Enhancement of Tumor Radiosensitivity and Metabolism In Vivo

A Universally EDTA-Assisted Synthesis of Polytypic Bismuth Telluride Nanoplates with a Size-Dependent Enhancement of Tumor Radiosensitivity and Metabolism In Vivo

Fe(III)-Doped Polyaminopyrrole Nanoparticle for Imaging-Guided Photothermal Therapy of Bladder Cancer

Emerging ultrasmall luminescent nanoprobes forin vivobioimaging

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