Recent advances in responsive hydrogels for diabetic wound healing

A hybrid hydrogel constructed using drug loaded mesoporous silica and multiple response copolymer as an intelligent dressing for wound healing of diabetic foot ulcers

“…5 Among them, hydrogel dressings are considered to be the most promising because they have a three-dimensional hydrophilic polymer network structure, can maintain a moist environment at the wound site, and have good biocompatibility, adjustable mechanical properties and a similar extracellular matrix, which are conducive to the formation of various skin tissues. 6–8…”

“…In recent years, materials based on phenylboric acid have been widely used in the field of wound repair. 8 Hydrogel dressings formed by borate bonds are very suitable for the diabetic wound microenvironment. Jiang and Ruan et al 13 synthesized borate micelles for loading insulin, and added drug-carrying micelles into hydrogels to prepare hydrogel dressings that can stabilize the blood sugar concentration and promote wound repair.…”

Flexible and temperature-responsive hydrogel dressing for real-time and remote wound healing monitoring

“…Skin injuries caused by a variety of bacterial infections have become a major problem that threatens human health. 1,2 Numbers of studies have proved that microbial infection is directly related to changes in the physiological signals of the local microenvironment of the wound surface, such as temperature, pH, enzymes, humidity, pressure and uric acid, [3][4][5][6] which often occur before clinically significant infection symptoms including redness, pain, and pustules. Therefore, in situ infection management strategies that can monitor changes in wound physiological signals are expected to achieve early warning of infection and thus to guide dynamic intervention treatment.…”

PLCL/PCL Dressings with Platelet Lysate and Growth Factors Embedded in Fibrin for Chronic Wound Regeneration

“…Several other advanced wound dressing strategies based on hydrocolloids, hydrogels, foams, and films incorporating exosomes, nanoparticles, and various bioactive compounds are studied aiming at improved healing by sustained release of stimulating mediators and drugs, as well as enhanced protection against bacterial infiltration. [47][48][49][50][51] The combination of biodegradable electrospun blend of PLCL/PCL nanofibers dressings with human platelet lysate and growth factors embedded in a fibrin mesh constitutes a good alternative for the healing of wounds by providing appropriate stimuli in the chronic wound. Importantly, nanofiber scaffolds can mimic ECM and therefore are an ideal material for tissue engineering in the regeneration of damaged skin with a nano-sized structure and a huge surface-to-volume ratio allowing increased loading capacity of the bioactive constituents.…”