Recent Advances in Sarcopenia Research in Asia: 2016 Update From the Asian Working Group for Sarcopenia

Chen, Liang Kung; Lee, Wei Ju; Peng, Li‐Ning; Liu, Li-Kuo; Arai, Hidenori; Akishita, Masahiro

doi:10.1016/j.jamda.2016.05.016

Cited by 282 publications

(249 citation statements)

References 90 publications

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“…In this study, 30 male participants (49%) and 70 female participants (54%) were below the threshold for HGS, according to the AWGS criteria [12]. Furthermore, the prevalence of sarcopenia according to the AWGS criteria [12] was 12% for males and 11% for females in this study (Table1).…”

Section: Discussionmentioning

confidence: 48%

“…The highest value of two trials was used in the analyses. We divided participants into low and normal hand grip groups, according to the Asian Working Group for Sarcopenia (AWGS; the cut-off thresholds of HGS for sarcopenia were 26 kg for males and 18 kg for females) [12]. We also used the AWGS criteria to diagnose sarcopenia.…”

Section: Physical Performance Evaluationmentioning

confidence: 99%

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Relationship between hand grip strength and peak VO₂ in community‐dwelling elderly outpatients

Sugie

Harada

Takahashi

et al. 2018

JCSM Clinical Reports

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Section: Discussionmentioning

confidence: 48%

Section: Physical Performance Evaluationmentioning

confidence: 99%

Relationship between hand grip strength and peak VO₂ in community‐dwelling elderly outpatients

Sugie

Harada

Takahashi

et al. 2018

JCSM Clinical Reports

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“…7 Kawakami et al 2 focused on calf circumference as a surrogate marker of sarcopenia diagnosis, and reported that calf circumference ≤33cm could be a surrogate marker of sarcopenia diagnosis for community-dwelling women. On the other hand, Ishii et al 8 reported that the presence or absence of sarcopenia is associated with age, grip strength, and calf circumference, and additionally reported that calf circumference in the non-sarcopenia women and the sarcopenia women were 34.5 ± 2.7 cm and 32.1 ± 2.1 cm on average, respectively.…”

Section: Discussionmentioning

confidence: 99%

Thigh and calf circumference for the sarcopenia screening in community-dwelling elderly women

2017

JCGG

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Background/Objectives: The purpose of this study was to investigate usefulness and limitations of measurement of thigh and calf circumference for the sarcopenia screening in community-dwelling elderly women. Methods: One-hundred sixteen community-dwelling elderly women were enrolled. Thigh and calf circumferences, grip strength, walking speed, Short Physical Performance Battery and Timed Up test and Go test were performed. Subjects were divided into two groups, the non-sarcopenia group and the sarcopenia group, and the measured values were compared between the two groups. The area under the receiver operating characteristic curve was calculated to determine the cut off values of each circumstance were determined by the presence or absence of sarcopenia. Results: Of all the subjects, non-sarcopenia subjects accounted for 91.4% (n=106), and sarcopenia subjects 8.6% (n=10). Thigh circumference and calf circumference of the dominant leg in sarcopenia subjects showed significant lower values than in non-sarcopenia subjects. Cut-off value for sarcopenia of thigh circumference was 37.3 cm (sensitivity 0.821, specificity 0.600, AUC 0.783, p<0.003), while that of the calf circumference was 32.8 cm (sensitivity 0.736, specificity 0.800, AUC 0.792, p<0.002). Conclusions: We confirmed that thigh and calf circumference could be used as a sarcopenia screening in community-dwelling elderly women. Since measurement of calf circumference is easier and calf circumference has high specificity of sarcopenia screening than thigh circumference, calf circumference is thought to have higher measurement significance in community-dwelling elderly women.

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“…Frailty, a functional status that precedes disability, is characterized by decreased functional reserve and increased vulnerability [73]. In addition to disability, the frailty phenotype predicts falls, institutionalization, hospitalization and mortality.…”

Section: The Relationship Between Androgen and Muscle Mass And Strengthmentioning

confidence: 99%

“…Frailty is promoted by the interaction between the aging process and some chronic diseases and conditions that compromise functional systems. Many of the clinical manifestations of frailty are explained by sarcopenia, which is closely related to poor physical performance due to muscle atrophy and fatigue [73]. Clinical studies indicate that testosterone replacement in hypogonadal men and men with sarcopenia associated with chronic illness has the potential to increase skeletal muscle mass and strength [74].…”

Section: The Relationship Between Androgen and Muscle Mass And Strengthmentioning

confidence: 99%

The biological and clinical advances of androgen receptor function in age-related diseases and cancer [Review]

Takayama

2017

Endocr J

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Abstract. Hormonal alterations with aging contribute to the pathogenesis of several diseases. Androgens mediate their effects predominantly through binding to the androgen receptor (AR), a member of the ligand-dependent nuclear receptor superfamily. By androgen treatment, AR is recruited to specific genomic loci dependent on tissue specific pioneer factors to regulate target gene expression. Recent studies have revealed the epigenetic modulation by AR-associated histone modifiers and the roles of non-coding RNAs in AR signaling. Androgens are male sex hormone to induce differentiation of the male reproductive system required for the establishment of adult sexual function. As shown by several reports using AR knockout mouse models, androgens also have anabolic functions in several tissues such as bone, muscle and central nervous systems. Notably, AR has a central role in prostate cancer progression. Prostate cancer is the most frequently diagnosed cancer in men. Androgen-deprivation therapy for cancer patients and decline of serum androgen with aging promote several diseases associated with aging and quality of life of older men such as osteoporosis, sarcopenia and dementia. Thus, androgen replacement therapy for treating late onset hypogonadism (LOH) or new epigenetic regulators have the potential to overcome the symptoms caused by the low androgen, although adverse effects for cardiovascular diseases have been reported. Given the increasing longevity and consequent rise of age-related diseases and prostate cancer patients, a more understanding of the AR actions in male health remains a high research priority.

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Recent Advances in Sarcopenia Research in Asia: 2016 Update From the Asian Working Group for Sarcopenia

Cited by 282 publications

References 90 publications

Relationship between hand grip strength and peak VO₂ in community‐dwelling elderly outpatients

Relationship between hand grip strength and peak VO₂ in community‐dwelling elderly outpatients

Thigh and calf circumference for the sarcopenia screening in community-dwelling elderly women

The biological and clinical advances of androgen receptor function in age-related diseases and cancer [Review]

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Recent Advances in Sarcopenia Research in Asia: 2016 Update From the Asian Working Group for Sarcopenia

Cited by 282 publications

References 90 publications

Relationship between hand grip strength and peak VO2 in community‐dwelling elderly outpatients

Relationship between hand grip strength and peak VO2 in community‐dwelling elderly outpatients

Thigh and calf circumference for the sarcopenia screening in community-dwelling elderly women

The biological and clinical advances of androgen receptor function in age-related diseases and cancer [Review]

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Product

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Relationship between hand grip strength and peak VO₂ in community‐dwelling elderly outpatients

Relationship between hand grip strength and peak VO₂ in community‐dwelling elderly outpatients