Relationship between hand grip strength and peak VO<sub>2</sub> in community‐dwelling elderly outpatients

Sugie, Masamitsu; Harada, Kazumasa; Takahashi, Toshio; Nara, Marina; Ishikawa, Joji; Tanaka, Jun; Koyama, Takeo; Fujimoto, Hajime; Obuchi, Shuichi; Kyo, Shunei; Ito, Hideki

doi:10.17987/jcsm-cr.v3i1.48

Cited by 10 publications

(12 citation statements)

References 29 publications

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“…Additionally, we confirm grip strength to be significantly associated with lean mass, fat mass, CR fitness, BMD, A/G ratio, disease prevalence and physical activity levels. Such findings are consistent with previous studies, reporting associations between grip strength and lean mass [ 35 ], body fat % [ 35 ], BMD [ 36 , 37 ], peak oxygen uptake (VO2 peak ) [ 38 ] and morbidity [ 12 ]. While no previous research has explored the relationship between grip performance and A/G ratio, studies have demonstrated significant negative associations between grip strength and waist circumference [ 17 , 18 ].…”

Section: Discussionsupporting

confidence: 92%

“…These findings are consistent with previous reports demonstrating stronger associations between low grip strength, BMD and physical activity levels among females, compared to males [39,40]. While we found associations between low grip strength and disease prevalence in males only, and similar associations with CR fitness in females only, two recent studies have reported significant associations between these variables across both sexes [38,41]. Such inconsistencies are underscored by an overall lack of research relating to specific grip strength cutoff points and health.…”

Section: Screening Utility Of Grip Strengthsupporting

confidence: 91%

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Grip strength performance from 9431 participants of the GenoFit study: normative data and associated factors

et al. 2021

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Weak grip strength is a strong predictor of multiple adverse health outcomes and an integral diagnostic component of sarcopenia. However, the limited availability of normative data for certain populations impedes the interpretation of grip performance across adulthood. This study aimed to establish normative data and low grip strength thresholds in a large adult population, and to examine associations between grip strength and clinically relevant health variables. A total of 9431 adults aged between 18 and 92 years participated in this study (mean age: 44.8 ± 13.4 years; 57% females). Grip strength, body composition, and cardiorespiratory (CR) fitness were assessed using hand dynamometry, dual-energy x-ray absorptiometry and physical work capacity tests, respectively. Low grip strength was established according to criteria of the European Working Group on Sarcopenia in Older People. Normative data and t-scores, stratified by sex and age groups, are presented. Grip performance was associated with lean mass, skeletal muscle index (SMI), fat mass, CR fitness, bone mineral density (BMD), android/gynoid ratio, disease prevalence and physical activity levels (all p < 0.001) after controlling for multiple potential confounders. Individuals with weak grip strength had lower lean mass, SMI, CR fitness (all p < 0.001) and BMD (p = 0.001), and higher disease prevalence (p < 0.001), compared to healthy controls, although sex-specific differences were observed. Grip strength has practical screening utility across a range of health domains. The normative data and grip strength thresholds established in this study can guide the clinical interpretation of grip performance and facilitate timely therapeutic strategies targeting sarcopenia.

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Section: Discussionsupporting

confidence: 92%

Section: Screening Utility Of Grip Strengthsupporting

confidence: 91%

Grip strength performance from 9431 participants of the GenoFit study: normative data and associated factors

et al. 2021

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“…We have previously reported associations between peak VO 2 and SMI, and peak VO 2 and HGS, which we suggested might be underpinned by the degradation of sarcomeric proteins in both skeletal muscle and cardiomyocytes via the ubiquitin–proteasome system 38 39 . Coen et al .…”

Section: Discussionmentioning

confidence: 75%

“…We have shown that peak VO 2 is independently associated with age, Hb, physical function (SMI, HGS, & u‐WS), fatiguability, and CHF ( Table 4). Although relationships between peak VO 2 and indexes such as age, 1,36 anaemia, 37 SMI, 38 HGS, 39 u‐WS, 40 fatiguability, 41 and CHF 42 have previously been reported, no previous studies have investigated the relationship between peak VO 2 and this cluster of sarcopenia, frailty, and cachexia‐related factors.…”

Section: Discussionmentioning

confidence: 99%

Peak oxygen uptake correlates with indices of sarcopenia, frailty, and cachexia in older Japanese outpatients

Sugie

Harada

Takahashi

et al. 2021

JCSM Rapid Communications

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Background Peak oxygen uptake (peak VO 2 ) is known not only as an index of aerobic fitness but also one of an index of life expectancy. Frailty, sarcopenia, and cachexia are associated with a poor prognosis and high mortality. The purpose of this study was to determine the relationships of peak VO 2 with the features of sarcopenia, frailty, and cachexia, to provide insight into which might mediate the poor prognosis. Methods The first group of participants was 175 community-dwelling older Japanese outpatients (58 men and 117 women; mean age 77.6 ± 6.4 years), in whom we assessed the features of sarcopenia, frailty, and cachexia, and measured peak VO 2 during cardiopulmonary exercise. To confirm the relationships, we analysed another group of 162 participants (77.3 ± 5.5 years). Results There were significant correlations between peak VO 2 and the features of sarcopenia, frailty, and cachexia, with the exception of high sensitivity C-reactive protein. Multiple linear regression analysis for the prediction of peak VO 2 (mL/min) identified following formula: predicted peak VO 2 = À11.6 × age (years) + 25.5 × haemoglobin concentration (g/dL) + 114.2 × skeletal muscle mass index (kg/m 2 ) + 8.9 × hand grip strength (kg) + 226.4 × usual walking speed (m/s) À 65.8 × fatiguability (absence 0, presence 1) À 177.4 × chronic heart failure (absence 0, presence 1) + 437.1 (R 2 = 0.627, P < 0.001). The validity of the formula was confirmed with another group (r = 0.78, P < 0.001). Conclusions This study has identified the features of sarcopenia, frailty, and cachexia that are related to peak VO 2 in an older population.

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“…Finally, exercise tolerance was assessed using cardiopulmonary exercise testing. All of these assessments were evaluated as previously described 10,14–17 …”

Section: Methodsmentioning

confidence: 99%

Effectiveness of a far‐infrared low‐temperature sauna program on geriatric syndrome and frailty in community‐dwelling older people

Sugie

Harada

Takahashi

et al. 2020

Geriatrics Gerontology Int

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Aim: Although it is known that geriatric syndrome is associated with the development of frailty, it is not known whether an amelioration of geriatric syndrome also improves shared risk factors and frailty. Methods: In total, 67 community-dwelling older people (79.6 AE 6.5 years, 49 women) participated in this study (41 were classified as pre-frail and 26 as frail). We analyzed indices of physical frailty and cognitive depression, exercise tolerance and health-related quality of life as frailty related indices, and the participants completed a questionnaire regarding common geriatric symptoms (cold extremities, leg edema, breathlessness, urinary incontinence, chronic headache, chronic pain, a sense of numbness, anorexia, constipation, insomnia and skin trouble) using numeric ratings. Frailty was evaluated using the Japanese version of the Cardiovascular Health Study (J-CHS) criteria. The participants then underwent a far-infrared low-temperature sauna (FILTS) program twice a week for 3 months and the above parameters were reassessed. Results: After the FILTS program, there were significant differences in usual walking speed, peak oxygen uptake, Geriatric Depression Scale-15, health-related quality of life and the severity of several geriatric symptoms. Of the 67 participants, 18 showed improvements in their J-CHS frailty score, 47 showed no change and two showed reductions. Linear regression analysis showed that the change in the numeric rating of the coldness of extremities (B = −0.105, P = 0.013) and the cumulative numeric rating for geriatric syndromes (B = 0.044, P < 0.001) were independent determinants of the change in the J-CHS score. Conclusions: A 3-month FILTS program ameliorates geriatric syndrome, the severity of frailty and frailty related indices in older Japanese people.

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Relationship between hand grip strength and peak VO₂ in community‐dwelling elderly outpatients

Abstract: Background Hand grip strength and peak oxygen uptake (VO 2 ) are important components of frailty. However, the relationship between these two variables among community-dwelling elderly people is still unclear. The present study aimed to investigate this relationship.

Cited by 10 publications

References 29 publications

Grip strength performance from 9431 participants of the GenoFit study: normative data and associated factors

Grip strength performance from 9431 participants of the GenoFit study: normative data and associated factors

Peak oxygen uptake correlates with indices of sarcopenia, frailty, and cachexia in older Japanese outpatients

Effectiveness of a far‐infrared low‐temperature sauna program on geriatric syndrome and frailty in community‐dwelling older people

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Relationship between hand grip strength and peak VO2 in community‐dwelling elderly outpatients

Abstract: Background Hand grip strength and peak oxygen uptake (VO 2 ) are important components of frailty. However, the relationship between these two variables among community-dwelling elderly people is still unclear. The present study aimed to investigate this relationship.

Cited by 10 publications

References 29 publications

Grip strength performance from 9431 participants of the GenoFit study: normative data and associated factors

Grip strength performance from 9431 participants of the GenoFit study: normative data and associated factors

Peak oxygen uptake correlates with indices of sarcopenia, frailty, and cachexia in older Japanese outpatients

Effectiveness of a far‐infrared low‐temperature sauna program on geriatric syndrome and frailty in community‐dwelling older people

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Relationship between hand grip strength and peak VO₂ in community‐dwelling elderly outpatients