Recent advances in silica-based biosensors: a review

Abstract

Silica has become a common platform for various catalytic and chemical reactions, biosensor, and drug release owing to its low toxicity, chemical and physical stabilities, large surface area, tunable pore sizes, and well-defined surface chemistry. Therefore, biomolecules encapsulated within a porous silica host has provoked significant interest in the development, application, and market of silica-based biosensors due to its potential application in analytic chemistry and biological science. Considerable progresses have been achieved in past few decades. This review focuses primarily on such advances in synthesis and applications of silica-based biosensors, especially emphasizing development which has occurred in the last 10 years, further driving readers to understand and construct various silica-based biosensors with high sensitivity and high stability.

A comprehensive review on bio‐mimicked multimolecular frameworks and supramolecules as scaffolds for enzyme immobilization

“…In former years, a series of nanoporous solid supports such as zeolites, mesoporous silica, carbonaceous materials, sol-gel hydrogels, organic-inorganic nanoflowers, and porous polymers have been widely adopted as alternative platforms for enzyme immobilizations whilst poor specific interactions occurred between biocatalyst molecules, and these mesoporous materials laid to the enzyme leaching, denaturations, and diffusional restrictions that adversely affect the enzymatic performance, enzyme recovery, and operational stabilities (J. Chen et al, 2015;Cipolatti et al, 2014).…”

“…Being stuffed with exceptionally outstanding intrinsic features, plenteous research has been published every year allied to the several facets of the MOFs which made them extremely popular among traditional organic or inorganic components that tend to lack structural flexibility and crystallinity (Furukawa et al, 2013). In former years, a series of nanoporous solid supports such as zeolites, mesoporous silica, carbonaceous materials, sol–gel hydrogels, organic–inorganic nanoflowers, and porous polymers have been widely adopted as alternative platforms for enzyme immobilizations whilst poor specific interactions occurred between biocatalyst molecules, and these mesoporous materials laid to the enzyme leaching, denaturations, and diffusional restrictions that adversely affect the enzymatic performance, enzyme recovery, and operational stabilities (J. Chen et al, 2015; Cipolatti et al, 2014).…”