Recent advances in synthesis of sugar and nucleoside coumarin conjugates and their biological impact

Kumar, Sumit; Arora, Aditi; Kumar, Rajesh; Senapati, Nihar Nalini; Singh, Brajendra K.

doi:10.1016/j.carres.2023.108857

Cited by 11 publications

(2 citation statements)

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“…Coumarins are a promising class of naturally occurring bioactive heterocycles with unique physical and chemical properties. Compounds containing the coumarin framework possess a wide range of pharmacological, biological, and physiological activities, which makes them important for application in medicine, the food industry and agriculture. – Among them, osthole has been widely used in agriculture as an insecticidal and bacteriostatic pesticide. , In addition, the introduction of coumarin parent nucleus into the structure of common fungicides can also improve its anti-fungal activity. For example, the microbicide eugenicide has excellent control effect on cucumber downy mildew and apple tree rot, which is obtained by introducing coumarin parent nucleus into the structure of traditional methoxyacrylate fungicide .…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and Biological Activities of Novel Coumarin Derivatives as Pesticide Candidates

Ma,

Wang,

Wang

et al. 2024

J. Agric. Food Chem.

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Food security is an important issue in the 21st century; preventing and controlling crop diseases and pests are the key to solve this problem. The creation of new pesticides based on natural products is an important and effective method. Herein, coumarins were selected as parent structures, and a series of their derivatives were designed, synthesized, and evaluated for their antiviral activities, fungicidal activities, and insecticidal activities. We found that coumarin derivatives exhibited good to excellent antiviral activities against tobacco mosaic virus (TMV). The antiviral activities of I-1, I-2a, I-4b, II-2c, II-2g, II-3, and II-3b are better than that of ribavirin at 500 μg/mL. Molecular docking research showed that these compounds had a strong interaction with TMV CP. These compounds also showed broad-spectrum fungicidal activities against 14 plant pathogenic fungi. The EC 50 values of I-1, I-2a, I-3c, and II-2d are in the range of 1.56−8.65 μg/mL against Rhizoctonia cerealis, Physalospora piricola, Sclerotinia sclerotiorum, and Pyricularia grisea. Most of the compounds also displayed good insecticidal activities against Mythimna separata. Pesticide-likeness analysis showed that these compounds are following pesticide-likeness and have the potential to be developed as pesticide candidates. The present work lays a foundation for the discovery of novel pesticide lead compounds based on coumarin derivatives.

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Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and Biological Activities of Novel Coumarin Derivatives as Pesticide Candidates

Ma,

Wang,

Wang

et al. 2024

J. Agric. Food Chem.

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“…For this purpose, we designed oxazine-coupled coumarin-based triazole-linked 33 modified nucleosides. 14,34–36 Herein, we present the synthesis and comprehensive fluorescence, photophysical and DFT studies on our newly synthesized novel fluorophores.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and photophysical studies of dual-emissive base-modified fluorescent nucleosides

Arora,

Kumar,

Kumar

et al. 2024

Org. Biomol. Chem.

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BF₃ ⋅ OEt₂ as a Versatile Reagent: Applications in Organic Synthesis

Kumar,

Arora,

Chaudhary

et al. 2024

ChemistrySelect

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Boron trifluoride diethyl etherate, commonly referred to as BF3 ⋅ OEt2, plays a crucial role as a potent reagent in various organic transformations, particularly in the synthesis of heterocyclic systems through the establishment of carbon‐carbon & carbon‐heteroatom bonds. Its Lewis acid properties, reactivity, and stability at room temperature make it essential for a wide range of chemical reactions. BF3 ⋅ OEt2 demonstrates remarkable efficacy in processes such as hydroxylation of double bonds, epoxide cleavage, acid esterification, cyanation, coupling, and diverse cyclization reactions, surpassing other Lewis acids in performance. Its significant impact on organic synthesis extends to the formation of natural products, highlighting its profound significance in the realm of chemistry. The unique properties and versatility of boron trifluoride diethyl etherate make it a fundamental tool for a diverse array of chemical transformations. The numerous applications of this reagent in organic synthesis have prompted the development of a comprehensive review, focusing on its various roles and contributions in this field.

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Recent advances in synthesis of sugar and nucleoside coumarin conjugates and their biological impact

Cited by 11 publications

References 131 publications

Design, Synthesis, and Biological Activities of Novel Coumarin Derivatives as Pesticide Candidates

Design, Synthesis, and Biological Activities of Novel Coumarin Derivatives as Pesticide Candidates

Synthesis, characterization and photophysical studies of dual-emissive base-modified fluorescent nucleosides

BF₃ ⋅ OEt₂ as a Versatile Reagent: Applications in Organic Synthesis

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Recent advances in synthesis of sugar and nucleoside coumarin conjugates and their biological impact

Cited by 11 publications

References 131 publications

Design, Synthesis, and Biological Activities of Novel Coumarin Derivatives as Pesticide Candidates

Design, Synthesis, and Biological Activities of Novel Coumarin Derivatives as Pesticide Candidates

Synthesis, characterization and photophysical studies of dual-emissive base-modified fluorescent nucleosides

BF3 ⋅ OEt2 as a Versatile Reagent: Applications in Organic Synthesis

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Product

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BF₃ ⋅ OEt₂ as a Versatile Reagent: Applications in Organic Synthesis