Recent advances in the analysis of antibiotics by CE and CEC

Pérez‐Fernández, Virginia; Domínguez‐Vega, Elena; Crego, Antonio L.; García, María Ángeles; Marina, Marı́a Luisa

doi:10.1002/elps.201100409

Cited by 44 publications

(19 citation statements)

References 87 publications

(100 reference statements)

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“…In general, the LODs of the developed chemometric models are acceptable because they are below the MRLs established by the FDA (300 µg/l), the European Union and the Codex Alimentarius Commission (100 µg/l) (Commission Regulation 37/2010). Also, this LOD (> 10 µg/l) is in agreement with the limits of detection reported by other authors that use complex methodologies such as thin layer chromatography (50-300 µg/l); capillary electrophoresis (2-9 µg/l) and biosensors (5-25 µg/l) (Oka et al 2000;Cháfer-Pericás et al 2010;Pérez-Fernández et al 2012). …”

Section: Discussionsupporting

confidence: 91%

Mid-infrared spectroscopy and multivariate analysis for determination of tetracycline residues in cow's milk

et al. 2018

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Mid-infrared spectroscopy and chemometric analysis were tested to determine tetracycline's residues in cow's milk. Cow's milk samples (n = 30) were spiked with tetracycline, chlortetracycline, and oxytetracycline in the range of 10-400 µg/l. Chemometric models to quantify each of the tetracycline's residues were developed by applying Partial Components Regression and Partial Least Squares algorithms. The Soft Independent Modeling of Class Analogy model was used to differentiate between pure milk and milk sample with tetracycline residues. The best models for predicting the levels of these antibiotics were obtained using Partial Least Square 1 algorithm (coefficient of determination between 0.997-0.999 and the standard error of calibration from 1.81 to 2.95). The Soft Independent Modeling of Class Analogy model showed well-separated groups allowing classification of milk samples and milk sample with antibiotics. The obtained results demonstrate the great analytical potential of chemometrics coupled with mid-infrared spectroscopy for the prediction of antibiotic in cow's milk at a concentration of microgram per litre (µg/l). This technique can be used to verify the safety of the milk rapidly and reliably. Antibiotics, human health, multivariate analysis, chemometrics, vibrational spectral dataThe tetracyclines (TCs) have a wide antibacterial range and bacteriostatic action, and a good activity against infections caused by a number of bacteria. The TCs are permitted in a diversity of food-producing animals (sheep, poultry, pigs, cattle and fish) (Debuf 1998). The usage of TCs in dairy husbandry and the failure to follow good veterinary practices can lead to unsafe residue concentrations in various tissues and milk, with potential adverse effects on human health (for example allergic reactions in some hypersensitive individuals). Also the TCs residues may affect aquatic ecosystems (Feng-Jiao et al. 2014).To guarantee high quality of human food, several regulatory authorities have defined the maximum residue limits (MRLs) allowing only trace amounts of residues of veterinary drugs in food for human intake. The MRLs are based on the acceptable daily intake of each drug; maximum food intake is also taken into account. The MRLs are established at mg·kg -1 or µg·kg -1. The US Food and Drug Administration (FDA) has set tolerances for the residues of tetracycline, chlortetracycline and oxytetracycline in bovine milk at 300 μg·l Avoidance of TC residues is an important focus of the dairy industry. Judicious use of antibiotics, followed by an appropriate milk withholding time and screening for residues are essential aspects of milk quality management for assuring human food safety (Boeckman and Carlson 2006). Consequently, it is important to develop analytical procedures capable of determining the levels of TCs and to evaluate their presence in milk in order to protect human health (Casella and Picerno 2009).

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Section: Discussionsupporting

confidence: 91%

Mid-infrared spectroscopy and multivariate analysis for determination of tetracycline residues in cow's milk

et al. 2018

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“…Several sample treatments are required in most cases to extract and pre-concentrate the analytes. Additionally, during CE analysis some inorganic ions, proteins, and other major compounds can affect the electrophoretic mobility [7].…”

Section: Separation Techniquesmentioning

confidence: 99%

Importance of Treatment Process on the Analysis of Penicillins in Milk Samples by Capillary Electrophoresis

Rodríguez¹,

Martínez²,

Ibarra³

et al. 2015

Field Effect Electroosmosis - A Novel Phenomenon in Electrokinetics and Its Applications in Capillary Electrophoresis

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“…Amino groups in the structure of antibiotics favor using ECL detection, and hence this detection system has been widely used in the determination of antibiotics . ECL detection is a kind of chemiluminescence where chemical luminescence emission is generated in the process of substance oxidation and reduction at an electrode surface.…”

Section: Ce With Other Spectroscopic Detection Systemsmentioning

confidence: 99%

“…This review covers all the literature concerning the separation and determination of antibiotics by CE from June 2011 to June 2013 as a continuation of previous reviews concerning this field . All CE modes are considered and the most significant applications of the developed methodologies are described.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in CE analysis of antibiotics and its use as chiral selectors

et al. 2014

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Antibiotics are a class of therapeutic molecules widely employed in both human and veterinary medicine. This article reviews the most recent advances in the analysis of antibiotics by CE in pharmaceutical, environmental, food, and biomedical fields. Emphasis is placed on the strategies to increase sensitivity as diverse off-line, in-line, and on-line preconcentration approaches and the use of different detection systems. The use of CE in the microchip format for the analysis of antibiotics is also reviewed in this article. Moreover, since the use of antibiotics as chiral selectors in CE has grown in the last years, a new section devoted to this aspect has been included. This review constitutes an update of previous published reviews and covers the literature published from June 2011 until June 2013.

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Recent advances in the analysis of antibiotics by CE and CEC

Cited by 44 publications

References 87 publications

Mid-infrared spectroscopy and multivariate analysis for determination of tetracycline residues in cow's milk

Mid-infrared spectroscopy and multivariate analysis for determination of tetracycline residues in cow's milk

Importance of Treatment Process on the Analysis of Penicillins in Milk Samples by Capillary Electrophoresis

Recent advances in CE analysis of antibiotics and its use as chiral selectors

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