Recent advances in the applications of CE to forensic sciences (2005–2007)

Tagliaro, Franco; Bortolotti, Federica

doi:10.1002/elps.200700708

Cited by 50 publications

(20 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CE finds a growing recognition in simultaneous determination of different chemical species in biological samples. In forensic science, automated CE instruments have also become commercially available [20,21]. But, it was not applicable for antidepressants when using normal aqueous buffer due to their hydrophobic nature.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of antidepressants by non-aqueous capillary electrophoresis-time of flight mass spectrometry

Sasajima

Lim

Takeuchi

et al. 2010

Journal of Chromatography A

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of antidepressants by non-aqueous capillary electrophoresis-time of flight mass spectrometry

Sasajima

Lim

Takeuchi

et al. 2010

Journal of Chromatography A

View full text Add to dashboard Cite

“…However, many contrasting data are available in literature and sensitivity of CDT still remains a controversial issue (12). A reason for this may be found in the plethora of analytical methods, cut-off and target molecules used to evaluate CDT in alcohol abusers (1,5,13–15). …”

Section: Discussionmentioning

confidence: 99%

False negativity to carbohydrate-deficient transferrin and drugs: a clinical case

et al. 2014

View full text Add to dashboard Cite

Introduction:In this work we report on the possible effect of the medical therapy on CDT concentration in a chronic alcohol abuser, with known medical history (July 2007 – April 2012) and alcohol abuse confirmed by relatives.Case history:At the end of 2007, patient displayed the following laboratory results: AST 137 U/L, ALT 120 U/L, GGT 434 U/L, MCV 101 fL and CDT 3.3%. On December 2007, after double coronary artery bypass surgery, he began a pharmacological treatment with amlodipine, perindopril, atorvastatin, isosorbide mononitrate, carvedilol, ticlopidine and pantoprazole. In the next months, until may 2011, the patient resumed alcohol abuse, as confirmed by relatives; however, CDT values were repeatedly found negative (0.8% and 1.1%) despite elevated transaminases and GGT, concurrent elevated ethyl glucuronide concentration (> 50 mg/L) and blood alcohol concentration (> 1 g/L). Alcohol consumption still continued despite increasing disulfiram doses ordered by an Alcohol Rehab Center. On May 2011, the patient was transferred to a private medical center where he currently lives.Conclusions:This study suggests the possibility that a medical therapy including different drugs may hamper the identification of chronic alcohol abusers by CDT.

show abstract

“…Because of high efficiency and resolving power characteristics, lower solvent consumption, small sample amounts, and expedite analyses, CE has gained popularity within the forensic scenario as an alternative or complementary technique to chromatography, being reviewed consistently [16,17]. The coupling of CE to MS combines the high speed and efficiency of CE with the universality, selectivity and sensitivity inherent to MS.…”

Section: Introductionmentioning

confidence: 99%

Simple method for determination of cocaine and main metabolites in urine by CE coupled to MS

et al. 2009

View full text Add to dashboard Cite

In this work, a simple method for the simultaneous determination of cocaine (COC) and five COC metabolites (benzoylecgonine, cocaethylene (CET), anhydroecgonine, anhydroecgonine methyl ester and ecgonine methyl ester) in human urine using CE coupled to MS via electrospray ionization (CE-ESI-MS) was developed and validated. Formic acid at 1 mol/L concentration was used as electrolyte whereas formic acid at 0.05 mol/L concentration in 1:1 methanol:water composed the coaxial sheath liquid at the ESI nozzle. The developed method presented good linearity in the dynamic range from 250 ng/mL to 5000 ng/mL (coefficient of determination greater than 0.98 for all compounds). LODs (signal-to-noise ratio of 3) were 100 ng/mL for COC and CET and 250 ng/mL for the other studied metabolites whereas LOQ's (signal-to-noise ratio of 10) were 250 ng/mL for COC and CET and 500 ng/mL for all other compounds. Intra-day precision and recovery tests estimated at three different concentration levels (500, 1500 and 5000 ng/mL) provided RSD lower than 10% (except anhydroecgonine, 18% RSD) and recoveries from 83-109% for all analytes. The method was successfully applied to real cases. For the positive urine samples, the presence of COC and its metabolites was further confirmed by MS/MS experiments.

show abstract

Recent advances in the applications of CE to forensic sciences (2005–2007)

Cited by 50 publications

References 76 publications

Simultaneous determination of antidepressants by non-aqueous capillary electrophoresis-time of flight mass spectrometry

Simultaneous determination of antidepressants by non-aqueous capillary electrophoresis-time of flight mass spectrometry

False negativity to carbohydrate-deficient transferrin and drugs: a clinical case

Simple method for determination of cocaine and main metabolites in urine by CE coupled to MS

Contact Info

Product

Resources

About