Recent advances in the bioanalytical and biomedical applications of DNA-templated silver nanoclusters

Xu, Jiaqi; Zhu, Xuanmeng; Zhou, Xi; Khusbu, Farjana Yeasmin; Ma, Changbei

doi:10.1016/j.trac.2019.115786

Cited by 61 publications

(31 citation statements)

References 133 publications

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“…Phototherapy is a promising cancer treatment technology with the advantages of minimal invasiveness, high efficacy, and low side effects. [93,202] PTT and PDT are the two main modalities of phototherapy. Although both require light irradiation and , respectively.…”

Section: Metal Nanoclusters For Targeted Phototherapymentioning

confidence: 99%

Engineering Metal Nanoclusters for Targeted Therapeutics: From Targeting Strategies to Therapeutic Applications

Lin

Goswami

Xue

et al. 2021

Adv Funct Materials

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Metal nanoclusters (NCs) have recently attracted great interest in biomedical applications due to their ultrasmall size, good biocompatibility, and unique molecule-like physical and chemical properties. Metal NCs can be rationally designed and integrated with various targeting moieties to achieve unique physicochemical properties and functions. For therapeutic applications, these multifunctional surface-modified NCs can provide distinctive advantages over native metal NCs, such as improved therapeutic effects and reduced side effects. In this review, the design principles of targeting strategies for metal NCs and their composites, including passive and active targeting, and physical and chemical targeting are first discussed. The authors then focus on the recent achievements in the application of metal NCs in targeted therapeutics, including chemotherapy, phototherapy, and radiotherapy. Finally, the authors' perspectives on the challenges and opportunities of developing metal NCs in targeted therapeutics, further paving their way for potential clinical applications are provided.

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Section: Metal Nanoclusters For Targeted Phototherapymentioning

confidence: 99%

Engineering Metal Nanoclusters for Targeted Therapeutics: From Targeting Strategies to Therapeutic Applications

Lin

Goswami

Xue

et al. 2021

Adv Funct Materials

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“…Among them, the fluorescent aptasensor is frequently used because of its high sensitivity and accuracy. Most fluorescent molecular beacons, however, such as common organic dyes and quantum dots, have poor photostability, cell toxicity, and large physical size [ 12 ]. Thus, a more stabilized and productive fluorescence aptasensor is urgently necessary.…”

Section: Introductionmentioning

confidence: 99%

A Novel Fluorescence Aptasensor Based on Magnetic Beads/Gold Nanoparticles/DNA-Stabilized Silver Nanoclusters for Detection of Salmonella Typhimurium

Yang

Pang

et al. 2022

Foods

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Salmonella Typhimurium (S. Typhimurium) is a globally distributed foodborne pathogen, which can lead to outbreaks of foodborne infectious diseases. It is essential to guarantee food safety by timely and correct detection of S. Typhimurium. In this investigation, an original fluorescence aptasensor was constructed to detect S. Typhimurium rapidly and sensitively. Through the coupling of magnetic beads, aptamer, and gold nanoparticles (AuNPs), a fluorescence quenching system with a “sandwich structure” was established. The aptamer acted as a link, and its specific binding to S. Typhimurium could release AuNPs from the system. Meanwhile, fluorescent DNA-stabilized silver nanoclusters (DNA-AgNCs) were synthesized. The fluorescence intensity changes caused by the fluorescence resonance energy transfer between DNA-AgNCs and AuNPs were utilized to detect S. Typhimurium. The purposed aptasensor exhibited high selectivity and sensitivity with a linear response to S. Typhimurium, ranging from 3.7 × 102 to 3.7 × 105 cfu/mL. The limit of detection (LOD) was estimated to be 98 cfu/mL within 2 h 10 min. In addition, this method showed excellent application for detection of S. Typhimurium in artificially contaminated milk, with LOD reaching 3.4 × 102 cfu/mL. Therefore, the developed fluorescence aptasensor has great potential to identify S. Typhimurium in foodstuffs.

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“…[4][5][6] Specically, silver nanoclusters (AgNCs) prepared by the reduction of silver ions in the presence of short DNA oligonucleotides have attracted great interest as potential diagnostic tools for their tunable and highly uorescent properties. 7 Recently, the use of RNA nanorings to encapsulate AgNCs has also been described. 8 Although studies have been conducted to try to correlate DNA sequences and lengths with the uorescence properties of AgNCs, 9 the signicance of the secondary structures of the DNA templates on the emission properties of the resulting AgNCs is still a matter of research.…”

Section: Introductionmentioning

confidence: 99%

Studies on the interactions of Ag(i) with DNA and their implication on the DNA-templated synthesis of silver nanoclusters and on the interaction with complementary DNA and RNA sequences

et al. 2021

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Recent advances in the bioanalytical and biomedical applications of DNA-templated silver nanoclusters

Cited by 61 publications

References 133 publications

Engineering Metal Nanoclusters for Targeted Therapeutics: From Targeting Strategies to Therapeutic Applications

Engineering Metal Nanoclusters for Targeted Therapeutics: From Targeting Strategies to Therapeutic Applications

A Novel Fluorescence Aptasensor Based on Magnetic Beads/Gold Nanoparticles/DNA-Stabilized Silver Nanoclusters for Detection of Salmonella Typhimurium

Studies on the interactions of Ag(i) with DNA and their implication on the DNA-templated synthesis of silver nanoclusters and on the interaction with complementary DNA and RNA sequences

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