Recent Advances in the Chemical Control of Oomycetes

Staub, T.; Hubele, Adolf

doi:10.1007/978-3-642-67778-6_8

Cited by 4 publications

(3 citation statements)

References 62 publications

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“…A number of systemic pesticides have been used against Oomycetes such as P. infestans . These include phenylamides, carbonates, cyano‐oxime, phosphonates, dimethomorph and strobilurins (Staub & Hubele, 1981; Schwinn, 1983; Griffith et al ., 1992; Copping & Hewitt, 1998). Of the carbonates, propamocarb and prothiocarb cause increased membrane permeability (Papavizas et al ., 1978) and it was suggested that this could be related to alterations in the fatty acid composition which are caused by low concentrations of propamocarb in both Pythium and Phytophthora species (Burden et al ., 1988).…”

Section: Introductionmentioning

confidence: 99%

A mandelamide pesticide alters lipid metabolism in Phytophthora infestans

Griffiths

Dancer²,

O’Neill³

et al. 2003

New Phytologist

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Summary• Several pesticide classes have been used for control of the notorious plant pathogen, Phytophthora infestans . Some of these alter lipids, suggesting that lipid metabolism may be a target site. Here, we investigate the action of a new, active, mandelamide compound, SX 623509 ( N -2 ′ -(4 ′′ -ethoxy-3 ′′ -methoxy) phenylethyl-3, 4-dichloromandelamide), on lipid metabolism.• Phytophthora infestans cultured in pea-broth or minimal media was exposed to different concentrations of SX 623509. Lipid metabolism was followed with radiolabelled acetate, choline or ethanolamine. Products were analysed following separation by thin-layer chromatography and gas-liquid chromatography.• SX 623509 reduced growth and lipid labelling from [ 14 C]acetate in both media. The inhibition in lipid labelling was not caused merely by a reduction in uptake of the radiolabelled precursor. There were changes in labelling patterns, particularly reductions in phosphatidylcholine and triacylglycerol and increases in phosphatidate and diacylglycerol. The effect of SX 623509 on phosphatidylcholine labelling was followed in more detail.• We conclude that the mandelamide pesticide SX 623509 reduces lipid synthesis at concentrations similar to those inhibiting growth. Specific effects on lipid labelling patterns are probably caused by inhibition of cholinephosphotransferase, which may be a future target site for pesticide development.

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Section: Introductionmentioning

confidence: 99%

A mandelamide pesticide alters lipid metabolism in Phytophthora infestans

Griffiths

Dancer²,

O’Neill³

et al. 2003

New Phytologist

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“…Oomycetes, such as P. infestans and P. capsici , cause important and devastating agricultural diseases of recognized importance, being considered high‐risk pathogens (Brent and Hollomon, 1998). In an effort to control these Oomycetes, a high percentage of pesticide expenditure has been spent along the two last centuries (Staub and Hubele, 1981; Copping and Hewitt, 1998). Lost of effectiveness and development of fungicide resistance have compromised control strategies and driven towards the continuous search for new fungicides (Griffiths et al., 2003).…”

Section: Discussionmentioning

confidence: 99%

Screening Study of Potential Lead Compounds for Natural Product‐based Fungicides Against Phytophthora Species

Fernández-Acero¹,

Carbú²,

Garrido³

et al. 2006

Journal of Phytopathology

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Phytophthora spp. is one of the phytopathogenic Oomycete responsible for many important crop losses. Relevant species are P. infestans (causing potato late blight) and P. capsici (causing blight in pepper). In recent years, the use of conventional fungicides has favoured the appearance of different resistant strains. This study analyses the effect of various compounds on these two Phytophthora species. Those compounds were designed on the basis of known structures of natural compounds to obtain a rational control of these fungal-like species. All the analysed products showed a fungistatic activity against both strains, one of them reduced mycelial growth by over 46% at 100 p.p.m.

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“…Foliar disease can be controlled by a number of pesticide classes (e.g. dithiocarbamates and thalimides) but these are not very effective for systemic infections and soil‐borne disease (Staub & Hubele, 1981; Schwinn, 1983; Cochwinn & Staub, 1995). Moreover, the Oomycetes are often very persistent because of the varieties of structures which can survive various environmental conditions.…”

Section: Introductionmentioning

confidence: 99%

Effect of culture conditions on the lipid composition of Phytophthora infestans

Griffiths

Dancer²,

O’Neill³

et al. 2003

New Phytologist

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Summary• Phytophthora infestans is one of the most important of all plant pathogens and there is a demand for its more effective control. One target area for pesticides is lipid metabolism. To provide background information for studies with pesticides, we examined the lipids of P. infestans and how their composition is altered by culture conditions.• Phytophthora infestans was grown in a pea-broth and three different minimal media. Acyl lipids were extracted, separated by thin-layer chromatography, identified and quantified. Total fatty acid patterns and those in individual lipid classes were measured by gas-liquid chromatography.• Major polar lipids were the phosphoglycerides, phosphatidylcholine > phosphatidylethanolamine > phosphatidylinositol. The proportion of total polar lipids was reduced in minimal media. The similar fatty acid patterns of phosphatidylcholine and phosphatidylethanolamine were consistent with their metabolic relationship. Phytophthora infestans contained significant amounts of 22C unsaturated fatty acids, in addition to common fungal or oomycete fatty acids. Growth on minimal media caused changes in fatty acid patterns with increases in palmitate and linoleate and decreases in oleate being most obvious. Particular changes were also associated with the specific fatty acid patterns of individual lipids.• The changes found in total fatty acids and in the acyl profiles of individual lipids suggest that desaturase activities are altered by growth conditions. These results and the greater proportions of storage triacylglycerol in minimal media agree with data for some other lower plants or fungi.

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Recent Advances in the Chemical Control of Oomycetes

Cited by 4 publications

References 62 publications

A mandelamide pesticide alters lipid metabolism in Phytophthora infestans

A mandelamide pesticide alters lipid metabolism in Phytophthora infestans

Screening Study of Potential Lead Compounds for Natural Product‐based Fungicides Against Phytophthora Species

Effect of culture conditions on the lipid composition of Phytophthora infestans

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